Circulating Organ-Specific MicroRNAs Serve as Biomarkers
... with some limitation of diagnostic accuracy [3,4]. Biochemical and immunological assays are either of low sensitivity or low specificity [5,6]. For example, biochemical biomarkers of serum creatinine and urine albumin are classical indicators of kidney injury following renal allo (xeno)-transplantat ...
... with some limitation of diagnostic accuracy [3,4]. Biochemical and immunological assays are either of low sensitivity or low specificity [5,6]. For example, biochemical biomarkers of serum creatinine and urine albumin are classical indicators of kidney injury following renal allo (xeno)-transplantat ...
Bell DC et al. Atopic eczema/skin barrier/immune
... hydration[15]. However, in all but the mildest cases emollients are insufficiently effective so a combination therapy is used with another agent targeting the inflammatory response. Topical corticosteroids act through the corticosteroid-receptor complex to downregulate synthesis of the proteins invo ...
... hydration[15]. However, in all but the mildest cases emollients are insufficiently effective so a combination therapy is used with another agent targeting the inflammatory response. Topical corticosteroids act through the corticosteroid-receptor complex to downregulate synthesis of the proteins invo ...
WJG-23-2870 - F6 Publishing Home
... avoid the bactericidal activity of acid, H. pylori secretes large amounts of surface-associated and cytosolic urease[6]. However, hydrolysis of urea (occurring in the gastric lumen) produces large amounts of ammonia, which is then protonated to create ammonium, thus creating a neutral bacterial micr ...
... avoid the bactericidal activity of acid, H. pylori secretes large amounts of surface-associated and cytosolic urease[6]. However, hydrolysis of urea (occurring in the gastric lumen) produces large amounts of ammonia, which is then protonated to create ammonium, thus creating a neutral bacterial micr ...
Materials and methods
... and Rathjen, 2010). PAMPs such as flagellin and elongation factor Tu (EF-Tu) are recognized by ...
... and Rathjen, 2010). PAMPs such as flagellin and elongation factor Tu (EF-Tu) are recognized by ...
The Role of Macrophages in Murine Intraocular - Ti
... from enucleation of the globe to eye-saving strategies like local radiation therapy (brachytherapy), thermotherapy or proton beam therapy of the tumour. In about 40% of cases of uveal melanoma metastases develop within 10 years (Singh, Shields et al. 2001). A special characteristic of intraocular me ...
... from enucleation of the globe to eye-saving strategies like local radiation therapy (brachytherapy), thermotherapy or proton beam therapy of the tumour. In about 40% of cases of uveal melanoma metastases develop within 10 years (Singh, Shields et al. 2001). A special characteristic of intraocular me ...
alopecia_areata 2012
... The mixed inflammatory-cell infiltrate contains T cells, mast cells, natural killer (NK) cells, and dendritic cells, among which CD8+ T cells are typically the first inflammatory cells seen to be entering the anagen hair-bulb epithelium. (A more detailed description of these cycles can be found in t ...
... The mixed inflammatory-cell infiltrate contains T cells, mast cells, natural killer (NK) cells, and dendritic cells, among which CD8+ T cells are typically the first inflammatory cells seen to be entering the anagen hair-bulb epithelium. (A more detailed description of these cycles can be found in t ...
Alopecia Areata - New England Journal of Medicine
... The mixed inflammatory-cell infiltrate contains T cells, mast cells, natural killer (NK) cells, and dendritic cells, among which CD8+ T cells are typically the first inflammatory cells seen to be entering the anagen hair-bulb epithelium. (A more detailed description of these cycles can be found in t ...
... The mixed inflammatory-cell infiltrate contains T cells, mast cells, natural killer (NK) cells, and dendritic cells, among which CD8+ T cells are typically the first inflammatory cells seen to be entering the anagen hair-bulb epithelium. (A more detailed description of these cycles can be found in t ...
Functional analysis of a zebrafish myd88 mutant identifies key
... signaling upon ligand binding is vital for initiation of the innate immune response. In human and mammalian models, myeloid differentiation factor 88 (MYD88) is known for its central role as an adaptor molecule in interleukin 1 receptor (IL-1R) and TLR signaling. The zebrafish is increasingly used a ...
... signaling upon ligand binding is vital for initiation of the innate immune response. In human and mammalian models, myeloid differentiation factor 88 (MYD88) is known for its central role as an adaptor molecule in interleukin 1 receptor (IL-1R) and TLR signaling. The zebrafish is increasingly used a ...
Leukocyte surface antigen CD47
... pathways that control blood pressure, tissue perfusion, and angiogenesis. Moreover, CD47 signaling in various cell types regulates pathways that can trigger cell death, limit stem cell self-renewal, regulate mitochondrial homeostasis and other differentiation pathways, and activate protective autoph ...
... pathways that control blood pressure, tissue perfusion, and angiogenesis. Moreover, CD47 signaling in various cell types regulates pathways that can trigger cell death, limit stem cell self-renewal, regulate mitochondrial homeostasis and other differentiation pathways, and activate protective autoph ...
experimental oncology and molecular medicine department
... • Tumor Genomics. The research activity covers all aspects of lung cancer with the final aim of making an impact on a disease that is a major health-care burden in terms of morbidity and mortality. The Unit uses an integrated approach that combines cellular and molecular biology, biochemistry, and ...
... • Tumor Genomics. The research activity covers all aspects of lung cancer with the final aim of making an impact on a disease that is a major health-care burden in terms of morbidity and mortality. The Unit uses an integrated approach that combines cellular and molecular biology, biochemistry, and ...
Factors Affecting Wound Healing
... The proliferative phase generally follows and overlaps with the inflammatory phase, and is characterized by epithelial proliferation and migration over the provisional matrix within the wound (re-epithelialization). In the reparative dermis, fibroblasts and endothelial cells are the most prominent c ...
... The proliferative phase generally follows and overlaps with the inflammatory phase, and is characterized by epithelial proliferation and migration over the provisional matrix within the wound (re-epithelialization). In the reparative dermis, fibroblasts and endothelial cells are the most prominent c ...
Wolbachia confers sex-specific resistance and tolerance to
... melanogaster carrying wMel shows reduced mortality during enteric – but not systemic ...
... melanogaster carrying wMel shows reduced mortality during enteric – but not systemic ...
Dengue hemorrhagic fever with special emphasis on
... 2. Dengue fever (DF) and dengue hemorrhagic fever (DHF); two types of clinical manifestation of dengue virus infection Dengue virus infection can be asymptomatic or causes two forms of illness, DF and DHF [4,5] (Table 1), although the majority of dengue virus infections are asymptomatic. DF is a sel ...
... 2. Dengue fever (DF) and dengue hemorrhagic fever (DHF); two types of clinical manifestation of dengue virus infection Dengue virus infection can be asymptomatic or causes two forms of illness, DF and DHF [4,5] (Table 1), although the majority of dengue virus infections are asymptomatic. DF is a sel ...
![Twelfth International Symposium July 2006 program [PDF 748.15KB]](http://s1.studyres.com/store/data/018138094_1-058f9fa3e04357cb3b914d3800f7ab67-300x300.png)
Twelfth International Symposium July 2006 program [PDF 748.15KB]
... the EBV field, as well as two plenary sessions from exceptional investigators outside the field to give us new perspectives on NF-kB signaling and antigen presentation. We will recognize another of our outstanding EBV investigators with the Henle Lectureship, and we will pay special tribute to two d ...
... the EBV field, as well as two plenary sessions from exceptional investigators outside the field to give us new perspectives on NF-kB signaling and antigen presentation. We will recognize another of our outstanding EBV investigators with the Henle Lectureship, and we will pay special tribute to two d ...
Transactivation and signaling functions of Tat are not correlated
... or endotoxin with the protein. LPS is the constituent component of Gram negative bacterial cell walls [41]. Endotoxins are negatively charged and copurify with similarly charged proteins like Tat. Even trace quantities of residual endotoxin could be highly toxic to the cells and tissues of mammalian ...
... or endotoxin with the protein. LPS is the constituent component of Gram negative bacterial cell walls [41]. Endotoxins are negatively charged and copurify with similarly charged proteins like Tat. Even trace quantities of residual endotoxin could be highly toxic to the cells and tissues of mammalian ...
Why do we study animal toxins?
... competitions (Darwin, 1859). Prey-predator interaction and prevention of pathogenesis while maintaining symbiosis in coexistence with enormous microbes are the key biological challenges (Cortez & Weitz, 2014; Lazzaro & Rolff, 2011; Yoshida et al, 2003). Accordingly, toxins are widely produced by all ...
... competitions (Darwin, 1859). Prey-predator interaction and prevention of pathogenesis while maintaining symbiosis in coexistence with enormous microbes are the key biological challenges (Cortez & Weitz, 2014; Lazzaro & Rolff, 2011; Yoshida et al, 2003). Accordingly, toxins are widely produced by all ...
Exosomes and Exosomal RNA – A Way of Cell-to-Cell
... These extracellular vesicles are released by most cells and found in many body fluids including plasma and urine. Exosomes differ compared to their donor cells in RNA, protein and lipid composition, and their molecular content has shown prognostic and diagnostic potential. Uveal melanoma is a tumour ...
... These extracellular vesicles are released by most cells and found in many body fluids including plasma and urine. Exosomes differ compared to their donor cells in RNA, protein and lipid composition, and their molecular content has shown prognostic and diagnostic potential. Uveal melanoma is a tumour ...
Endometritis in old mares - Pferdeheilkunde Equine Medicine
... inflammation) and IL10 3 hours after challenge (Christoffersen et al. 2012b). Mycobacterial cell wall extract (MCWE) has also been used as a proactive treatment for persistent endometritis, and was found to decrease the number of mares with endometritis after challenge with Streptococcus zooepidemic ...
... inflammation) and IL10 3 hours after challenge (Christoffersen et al. 2012b). Mycobacterial cell wall extract (MCWE) has also been used as a proactive treatment for persistent endometritis, and was found to decrease the number of mares with endometritis after challenge with Streptococcus zooepidemic ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑