Identification of causal genes for complex traits
... model organism studies is a major, labor-intensive process involving generating gene knockouts. Therefore, it is often the case that identifying the causal genes at an associated locus requires a larger effort than the initial GWAS (Flint and Eskin, 2012). In addition to large LD blocks, fine-mappin ...
... model organism studies is a major, labor-intensive process involving generating gene knockouts. Therefore, it is often the case that identifying the causal genes at an associated locus requires a larger effort than the initial GWAS (Flint and Eskin, 2012). In addition to large LD blocks, fine-mappin ...
Comprehensive analysis of thiopurine S
... TPMT activity [19,20]. Numerous clinical studies have shown that TPMTdeficient patients are at high risk for severe and sometimes fatal haematotoxicity due to the accumulation of cytotoxic metabolites after treatment with standard doses of thiopurines [11,21–24]. In addition, patients who are hetero ...
... TPMT activity [19,20]. Numerous clinical studies have shown that TPMTdeficient patients are at high risk for severe and sometimes fatal haematotoxicity due to the accumulation of cytotoxic metabolites after treatment with standard doses of thiopurines [11,21–24]. In addition, patients who are hetero ...
PowerPoint Presentation - No Slide Title
... – Epistasis (G X G effects between loci) – Environment (G X E effects) ...
... – Epistasis (G X G effects between loci) – Environment (G X E effects) ...
Modifying effects of phenotypic plasticity on interactions among
... Huntingford, 2004). These examples suggest that plasticity may drive initial phenotypic divergence in some cases, and that genetic changes may follow in the direction of the plastic response (Pigliucci & Murren, 2003; Price et al., 2003; West-Eberhard, 2003; Crispo, 2007; Ghalambor et al., 2007). Ho ...
... Huntingford, 2004). These examples suggest that plasticity may drive initial phenotypic divergence in some cases, and that genetic changes may follow in the direction of the plastic response (Pigliucci & Murren, 2003; Price et al., 2003; West-Eberhard, 2003; Crispo, 2007; Ghalambor et al., 2007). Ho ...
The environment and the genotype in
... emphasize that the phenotype of an organism is the result of interaction between the genotype and the environment. It follows therefore, that any feature which gains expression in the phenotype must have a genetic basis. Most workers agree that polymorphism is not concerned with continuous variation ...
... emphasize that the phenotype of an organism is the result of interaction between the genotype and the environment. It follows therefore, that any feature which gains expression in the phenotype must have a genetic basis. Most workers agree that polymorphism is not concerned with continuous variation ...
PDF
... patterns of linkage disequilibrium in whole genome resequencing data from 30 diploid honeybees to construct a fine-scale map of rates of crossing over in the genome. We find that, in contrast to vertebrate genomes, the recombination landscape is not strongly punctate. Crossover rates strongly correl ...
... patterns of linkage disequilibrium in whole genome resequencing data from 30 diploid honeybees to construct a fine-scale map of rates of crossing over in the genome. We find that, in contrast to vertebrate genomes, the recombination landscape is not strongly punctate. Crossover rates strongly correl ...
A High Density Integrated Genetic Linkage Map of Soybean and the
... retains many homeologous and other duplicated genomic segments (Shoemaker et al., 1996). The high-throughput nature of the GoldenGate assay makes it a good platform for genotyping biparentallyderived populations used in QTL mapping. For the ~2500cM genetic map of soybean, a QTL detection study would ...
... retains many homeologous and other duplicated genomic segments (Shoemaker et al., 1996). The high-throughput nature of the GoldenGate assay makes it a good platform for genotyping biparentallyderived populations used in QTL mapping. For the ~2500cM genetic map of soybean, a QTL detection study would ...
ovo D1
... See how the phenotype changes when you: (1) hold the number of mutant alleles constant and change the number of wildtype alleles. increased dose of wildtype, phenotype more wildtype (2) hold the number of wildtype alleles constant and change the number of mutant alleles. increased dose of mutant, p ...
... See how the phenotype changes when you: (1) hold the number of mutant alleles constant and change the number of wildtype alleles. increased dose of wildtype, phenotype more wildtype (2) hold the number of wildtype alleles constant and change the number of mutant alleles. increased dose of mutant, p ...
Not all mutant phenotypes are equally informative. Forward genetics
... fact: it’s easier to mess things up than to make them better ...
... fact: it’s easier to mess things up than to make them better ...
Phenotype Curation Tool and Ontologies at dictyBase
... • Developed in collaboration with NCBO • Similar in functionality to Phenote • Web-based tool that can be accessed from any computer ...
... • Developed in collaboration with NCBO • Similar in functionality to Phenote • Web-based tool that can be accessed from any computer ...
The importance of genetic influences in asthma REVIEW H. Los* , G.H. Koppelman*
... population study of 131 families ascertained through general practice register in Southampton, UK was undertaken in 1994. The phenotype of asthma was established by questionnaire and by measurements of bronchial hyperresponsiveness to histamine inhalation, atopic status was determined by total IgE l ...
... population study of 131 families ascertained through general practice register in Southampton, UK was undertaken in 1994. The phenotype of asthma was established by questionnaire and by measurements of bronchial hyperresponsiveness to histamine inhalation, atopic status was determined by total IgE l ...
Phenotype Variations of TAS2R38 Gene and Its Bioecological
... with the other basic senses (sight, hear, smell, touch), the sense of taste also takes part. Different substances when penetrating into the mouth cavity cause the activation of receptor cells, which results in a specific feeling – sense of taste. The taste is based on the five basic senses (bitter, ...
... with the other basic senses (sight, hear, smell, touch), the sense of taste also takes part. Different substances when penetrating into the mouth cavity cause the activation of receptor cells, which results in a specific feeling – sense of taste. The taste is based on the five basic senses (bitter, ...
Ordered subset analysis in genetic linkage mapping of complex traits
... present the results of a simulation study evaluating type I error rates and power for a variety of genetic models consistent with a complex genetic trait. We find that OSA preserves the appropriate type I error rates. Furthermore, compared to analyses that do not use the covariate information but do ...
... present the results of a simulation study evaluating type I error rates and power for a variety of genetic models consistent with a complex genetic trait. We find that OSA preserves the appropriate type I error rates. Furthermore, compared to analyses that do not use the covariate information but do ...
Brahman Genetics Negatively Impact Protein Degradation and
... scores of strip loin steak tenderness, connective tissue, and juiciness decreased (linear, P<0.01), indicating that steaks were tougher, had more connective tissue, and were less juicy. Brahman genetics had no effect on beef flavor or off-flavor scores (P>0.35). Tenderness is influenced by two disti ...
... scores of strip loin steak tenderness, connective tissue, and juiciness decreased (linear, P<0.01), indicating that steaks were tougher, had more connective tissue, and were less juicy. Brahman genetics had no effect on beef flavor or off-flavor scores (P>0.35). Tenderness is influenced by two disti ...
Relative Paucity of Genes Causing Inviability in Hybrids
... genes from another species. Thus, if sex-limited F1 sterility and inviability involves partially recessive alleles, it must be based on X-linked genes of that type interacting with semidominant alleles from another species. Testing such genetic interactions [posited by Turelli and Orr (1995) to be a ...
... genes from another species. Thus, if sex-limited F1 sterility and inviability involves partially recessive alleles, it must be based on X-linked genes of that type interacting with semidominant alleles from another species. Testing such genetic interactions [posited by Turelli and Orr (1995) to be a ...
Pedigree Analysis
... their children. Subsequent generations are therefore written underneath the parental generations and the oldest individuals are found at the top of the pedigree. If the purpose of a pedigree is to analyze the pattern of inheritance of a particular trait, it is customary to shade in the symbol of all ...
... their children. Subsequent generations are therefore written underneath the parental generations and the oldest individuals are found at the top of the pedigree. If the purpose of a pedigree is to analyze the pattern of inheritance of a particular trait, it is customary to shade in the symbol of all ...
Ophthalmic Genetics Update Genetics and Genomics of
... significantly advanced in recent years at the genome, the transcriptome, and the proteome levels. Collectively, these data support the pathogenetic concept of PEX syndrome as a type of stress-induced elastosis associated with the excessive production and abnormal cross-linking of elastic microfibril ...
... significantly advanced in recent years at the genome, the transcriptome, and the proteome levels. Collectively, these data support the pathogenetic concept of PEX syndrome as a type of stress-induced elastosis associated with the excessive production and abnormal cross-linking of elastic microfibril ...
A QTL affecting daily feed intake maps to Chromosome 2 in pigs
... and the proportion of animals with missing genotype information. The statistical principles of Haley et al. (1994) were then applied to perform the QTL analysis in which the genotype information is used to calculate the probabilities of F2 individuals having a particular putative QTL genotype, based ...
... and the proportion of animals with missing genotype information. The statistical principles of Haley et al. (1994) were then applied to perform the QTL analysis in which the genotype information is used to calculate the probabilities of F2 individuals having a particular putative QTL genotype, based ...
Assessing homology at different levels of the biological hierarchy
... Title of Talk: Assessing homology at different levels of the biological hierarchy Brian K. Hall "I will grant that someone might be able to generate an original thought concerning homology, but I doubt it." (Wake, 1999, p. 24) ...
... Title of Talk: Assessing homology at different levels of the biological hierarchy Brian K. Hall "I will grant that someone might be able to generate an original thought concerning homology, but I doubt it." (Wake, 1999, p. 24) ...
Mendel and modern genetics: the legacy for today
... It was during his period as a teacher at the newly opened Realschule that Mendel began his systematic breeding experiments with Pisum. One of the major reasons that has been put forward to explain why a clergyman and schoolteacher would have undertaken such an unusual investigation is that he wanted ...
... It was during his period as a teacher at the newly opened Realschule that Mendel began his systematic breeding experiments with Pisum. One of the major reasons that has been put forward to explain why a clergyman and schoolteacher would have undertaken such an unusual investigation is that he wanted ...
Calculation of allele frequencies of breeding
... the same eye color, hair color, or body build as you? Variation is easy for us to see in humans, but variations exist in all organisms. To us, all mosquitoes look the same, but upon closer observation, we can see many variations in the population of mosquitoes. These variations arise from random mut ...
... the same eye color, hair color, or body build as you? Variation is easy for us to see in humans, but variations exist in all organisms. To us, all mosquitoes look the same, but upon closer observation, we can see many variations in the population of mosquitoes. These variations arise from random mut ...
Mendel and modern genetics: the legacy for today
... It was during his period as a teacher at the newly opened Realschule that Mendel began his systematic breeding experiments with Pisum. One of the major reasons that has been put forward to explain why a clergyman and schoolteacher would have undertaken such an unusual investigation is that he wanted ...
... It was during his period as a teacher at the newly opened Realschule that Mendel began his systematic breeding experiments with Pisum. One of the major reasons that has been put forward to explain why a clergyman and schoolteacher would have undertaken such an unusual investigation is that he wanted ...
Candidate Gene Association Mapping of Arabidopsis
... time remains unexplained (Werner et al. 2005a). In recent years, structured association mapping has emerged as a major tool in the search for genes that underlie quantitative trait variation (e.g., Yu et al. 2006), including natural variation in flowering time in A. thaliana. Although genomewide ass ...
... time remains unexplained (Werner et al. 2005a). In recent years, structured association mapping has emerged as a major tool in the search for genes that underlie quantitative trait variation (e.g., Yu et al. 2006), including natural variation in flowering time in A. thaliana. Although genomewide ass ...
Joseph L. Izzo, Jr Answer the Genetic Riddle Aging and Systolic
... wide open to the age-related patterns of traits or phenotypes in identifiable at-risk individuals, we may be able to take advantage of the pleiotropic nature of the syndrome of essential hypertension in a way that makes genetic association studies more focused and specific. In this complex setting, ...
... wide open to the age-related patterns of traits or phenotypes in identifiable at-risk individuals, we may be able to take advantage of the pleiotropic nature of the syndrome of essential hypertension in a way that makes genetic association studies more focused and specific. In this complex setting, ...
Daniël van Draanen - Utrecht University Repository
... traits is limited to outer visible traits like eye colour, hair colour and skin texture (WoodRobinson, Lewis, & Leach, 2000). Further findings about educational use of the terms are discussed in paragraph 3.5 of the theoretical basis. According to concept learning theories, students have a prototyp ...
... traits is limited to outer visible traits like eye colour, hair colour and skin texture (WoodRobinson, Lewis, & Leach, 2000). Further findings about educational use of the terms are discussed in paragraph 3.5 of the theoretical basis. According to concept learning theories, students have a prototyp ...
Behavioural genetics
Behavioural genetics, also commonly referred to as behaviour genetics, is the field of study that examines the role of genetic and environmental influences on animal (including human) behaviour. Often associated with the ""nature versus nurture"" debate, behavioural genetics is highly interdisciplinary, involving contributions from biology, neuroscience, genetics, epigenetics, ethology, psychology, and statistics. Behavioural geneticists study the inheritance of behavioural traits. In humans, this information is often gathered through the use of the twin study or adoption study. In animal studies, breeding, transgenesis, and gene knockout techniques are common. Psychiatric genetics is a closely related field.