Curcuma longa - The Biotechnology Institute
... avoided. With that, NF-kB protein is overly expressed, which allows cancer cells to proliferate infinitely. However, antioxidants reduce oxidative stress in the cells and reverse this situation. Curcuma longa activates the inserted p53 gene and deactivates the NF-kB protein. Thus, apoptosis is induc ...
... avoided. With that, NF-kB protein is overly expressed, which allows cancer cells to proliferate infinitely. However, antioxidants reduce oxidative stress in the cells and reverse this situation. Curcuma longa activates the inserted p53 gene and deactivates the NF-kB protein. Thus, apoptosis is induc ...
comparison of p53 expression in hpv(+)
... and Yap Eye Hospital. All samples were deparaffinized and cut in slices. Then it was stained using DO-7 humanized monoclonal antibody to observe the expression of p53 and the presence of HPV was detected by mouse monoclonal antibody K1H8 staining. Result: There were 15 samples that were included in ...
... and Yap Eye Hospital. All samples were deparaffinized and cut in slices. Then it was stained using DO-7 humanized monoclonal antibody to observe the expression of p53 and the presence of HPV was detected by mouse monoclonal antibody K1H8 staining. Result: There were 15 samples that were included in ...
Process Draft - WordPress.com
... In addition to activating p53, phloretin exposure leads to decreased levels of the B-cell lymphoma 2 (Bcl-2) protein and increased levels of the Bcl-2-associated X protein (BAX) protein (Kundu, Chun, Chae, & Kundu, 2014). The changes in these protein levels are not directly due to phloretin, but to ...
... In addition to activating p53, phloretin exposure leads to decreased levels of the B-cell lymphoma 2 (Bcl-2) protein and increased levels of the Bcl-2-associated X protein (BAX) protein (Kundu, Chun, Chae, & Kundu, 2014). The changes in these protein levels are not directly due to phloretin, but to ...
Questions to lecture 15. Cancer
... initiation, promotion and progression sister chromatid exchange, chromosomal translocation and carcinoma oncogene activation, loss of tumor suppressor gene and cancer None of the above ...
... initiation, promotion and progression sister chromatid exchange, chromosomal translocation and carcinoma oncogene activation, loss of tumor suppressor gene and cancer None of the above ...
Gene Section P53 (Protein 53 kDa) Atlas of Genetics and Cytogenetics
... eliminated. In both cases, the consequence is to prevent propogation of cells containing genetic alterations. ...
... eliminated. In both cases, the consequence is to prevent propogation of cells containing genetic alterations. ...
Gene Section USP7 (ubiquitin specific peptidase 7 (herpes virus- associated))
... murine thymocytes, USP7 specifically processes dexamethasone and gamma irradiation induced cell death (Vugmeyster et al., 2002). High expression was found in thymus, spleen and brain, organs which rely on apoptosis for development. A similar observation was not observed in caspase 3-deficient thymoc ...
... murine thymocytes, USP7 specifically processes dexamethasone and gamma irradiation induced cell death (Vugmeyster et al., 2002). High expression was found in thymus, spleen and brain, organs which rely on apoptosis for development. A similar observation was not observed in caspase 3-deficient thymoc ...
How oncoproteins regulate gene expression
... BB40118: Current topics in gene regulation and expression ...
... BB40118: Current topics in gene regulation and expression ...
Supplementary Information
... SDS-PAGE and stained with Coomassie. The upper rectangle indicates the gel sections where p53 was detected by MS analysis and the lower rectangle indicates the region of Cyp18, analysed by MS. P53- and Cyp18-relevant peptides identified by MS/MS are indicated. ...
... SDS-PAGE and stained with Coomassie. The upper rectangle indicates the gel sections where p53 was detected by MS analysis and the lower rectangle indicates the region of Cyp18, analysed by MS. P53- and Cyp18-relevant peptides identified by MS/MS are indicated. ...
Cancer Lab p53 – Teacher Background
... symbol is TP53. TheTP53 gene codes for the TP53 (p53) protein which acts as a tumor suppressor and works in response to DNA damage to orchestrate the repair of damaged DNA. If the DNA cannot be repaired, the p53 protein prevents the cell from dividing and signals it to undergo apoptosis (programmed ...
... symbol is TP53. TheTP53 gene codes for the TP53 (p53) protein which acts as a tumor suppressor and works in response to DNA damage to orchestrate the repair of damaged DNA. If the DNA cannot be repaired, the p53 protein prevents the cell from dividing and signals it to undergo apoptosis (programmed ...
PINK1 positively regulates HDAC3 to suppress p53
... suppressing p53-dependent apoptosis has been recently emphasized; however, the molecular basis of modulation of p53 function by HDAC3 remains unclear. Here, we show that cytoplasmic PTEN-induced putative kinase 1 (PINK1) directly binds to and phosphorylates HDAC3 at Ser-424 to enhance its histone de ...
... suppressing p53-dependent apoptosis has been recently emphasized; however, the molecular basis of modulation of p53 function by HDAC3 remains unclear. Here, we show that cytoplasmic PTEN-induced putative kinase 1 (PINK1) directly binds to and phosphorylates HDAC3 at Ser-424 to enhance its histone de ...
Tumor Suppressor Genes
... Ionizing radiation Drugs (bleomycin, 5-FU, adriamycin) Hypoxia Oncogenes (eg. Ras, Myc, SV40-T) Transfection and other forms of cellular stress; including “growth factor deprivation” induces a p53 response often resultin in apoptosis. ...
... Ionizing radiation Drugs (bleomycin, 5-FU, adriamycin) Hypoxia Oncogenes (eg. Ras, Myc, SV40-T) Transfection and other forms of cellular stress; including “growth factor deprivation” induces a p53 response often resultin in apoptosis. ...
paracrine NO, neurotransmitters, … endocrine any hormone any
... According to the endosymbiosis theory, mitochondria were once mutualistic bacteria in primitive eukaryotic cells. Peptide signal molecules bind to cell surface receptors. Exosomes are membrane enclosed packets of protein or RNA that are released from cells. Nitric oxide (NO) is a paracrine signal mo ...
... According to the endosymbiosis theory, mitochondria were once mutualistic bacteria in primitive eukaryotic cells. Peptide signal molecules bind to cell surface receptors. Exosomes are membrane enclosed packets of protein or RNA that are released from cells. Nitric oxide (NO) is a paracrine signal mo ...
Cell Cycle, Cancer, and the Biology Student Workbench
... p53 is a tumor suppressor gene. It turns on other genes that inhibit the cell cycle. If p53 is mutated, the mutant form results in a protein that cannot perform its function. Its disruption is associated with approximately 50 to 55 percent of human cancers As a result, the cell cycle has no “brakes” ...
... p53 is a tumor suppressor gene. It turns on other genes that inhibit the cell cycle. If p53 is mutated, the mutant form results in a protein that cannot perform its function. Its disruption is associated with approximately 50 to 55 percent of human cancers As a result, the cell cycle has no “brakes” ...
View Poster
... Objective & Hypotheses Programmed cell “suicide”—apoptosis—occurs in normal cells that turn cancerous (Böttger et al, 2008). The primary mechanism of apoptosis occurs in the nucleus using a special protein: p53, but secondary action may occur in the mitochondria, mediated by a certain enzyme: HAUSP ...
... Objective & Hypotheses Programmed cell “suicide”—apoptosis—occurs in normal cells that turn cancerous (Böttger et al, 2008). The primary mechanism of apoptosis occurs in the nucleus using a special protein: p53, but secondary action may occur in the mitochondria, mediated by a certain enzyme: HAUSP ...
The Fusarium toxin Enniatin exerts p53
... The major mechanism to induce apoptosis is believed to work transcriptionally via p53 binding to the promoter region of bax, a proapoptotic member of the bcl-2 protein family. But there also exists a less common, p53-mediated way of inducing apoptosis, believed to be independent of transcription reg ...
... The major mechanism to induce apoptosis is believed to work transcriptionally via p53 binding to the promoter region of bax, a proapoptotic member of the bcl-2 protein family. But there also exists a less common, p53-mediated way of inducing apoptosis, believed to be independent of transcription reg ...
Annotated Bibliography "Primary Information of P53 Gene
... provided an overview of attempt to fix the p53 gene to prevent/stop cancer. Maybe I can find flaws or errors with their methods and see what happens if you fix them – this will be an important part because it provides in-depth information about past attempt to target and change the gene. Brachmann, ...
... provided an overview of attempt to fix the p53 gene to prevent/stop cancer. Maybe I can find flaws or errors with their methods and see what happens if you fix them – this will be an important part because it provides in-depth information about past attempt to target and change the gene. Brachmann, ...
Resveraterol-Curcumin Extreme-P53
... at the World Health Organization's International Agency for Research on Cancer in Lyons, France, wrote in the journal Cancer Gene Therapy this fall. Arnold Levine, a cancer expert at the Institute for Advanced Study in Princeton, N.J., who discovered p53 almost 30 years ago, said, "We have uncovered ...
... at the World Health Organization's International Agency for Research on Cancer in Lyons, France, wrote in the journal Cancer Gene Therapy this fall. Arnold Levine, a cancer expert at the Institute for Advanced Study in Princeton, N.J., who discovered p53 almost 30 years ago, said, "We have uncovered ...
Role of tumor suppressor WOX1 in breast cancer cell migration
... acts as a proapoptotic protein and tumor suppressor. Loss of heterozygosity and chromosomal rearrangement of the WOX1 gene is associated with ovarian, breast, hepatocellular, and prostate carcinomas. In addition, loss of WOX1 expression results in tumorigenesis. WOX1 is also associated with malignan ...
... acts as a proapoptotic protein and tumor suppressor. Loss of heterozygosity and chromosomal rearrangement of the WOX1 gene is associated with ovarian, breast, hepatocellular, and prostate carcinomas. In addition, loss of WOX1 expression results in tumorigenesis. WOX1 is also associated with malignan ...
LECTURE #10: Cancer- A Deeper Look
... • Chemicals – tar from cigarettes • Virus infection – papilloma virus can be responsible for cervical cancer. • Hereditary predisposition – Some families are more susceptible to getting certain cancers. – Remember you can’t inherit ...
... • Chemicals – tar from cigarettes • Virus infection – papilloma virus can be responsible for cervical cancer. • Hereditary predisposition – Some families are more susceptible to getting certain cancers. – Remember you can’t inherit ...
Heterochromatin silencing at p53 target genes by a small viral protein.
... • p53 induction and phosphorylation is tantamount to p53 activity, which is the premise for several cancer therapies. • Identified, E4-ORF3, directing SUV39H1/2 H3K9me3 heterochromatin assembly at p53 target promoters to silence p53 activated transcription in response to genotoxic and oncogenic stre ...
... • p53 induction and phosphorylation is tantamount to p53 activity, which is the premise for several cancer therapies. • Identified, E4-ORF3, directing SUV39H1/2 H3K9me3 heterochromatin assembly at p53 target promoters to silence p53 activated transcription in response to genotoxic and oncogenic stre ...
Spontaneous tumorigenesis studies
... Suppl. Figure 1. A multi-step model for tumor development in Rassf1a, p53 single and double mutant mice. a) wildtype mouse; very slow tumor development. b) Rassf1a-/- p53+/- mouse; in the situation where an active p53 allele is retained, as well as its ability to overrule the mitotic defects dictate ...
... Suppl. Figure 1. A multi-step model for tumor development in Rassf1a, p53 single and double mutant mice. a) wildtype mouse; very slow tumor development. b) Rassf1a-/- p53+/- mouse; in the situation where an active p53 allele is retained, as well as its ability to overrule the mitotic defects dictate ...
The Cell Cycle
... S-Phase Controls • Replication must occur only 1 time / cell cycle • Origin “licensing” • ORC – origin recognition complex • SPF – S-phase promoting factor • Mcms – helicases that are only loaded once ...
... S-Phase Controls • Replication must occur only 1 time / cell cycle • Origin “licensing” • ORC – origin recognition complex • SPF – S-phase promoting factor • Mcms – helicases that are only loaded once ...
P53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). This homolog (originally thought to be, and often spoken of as, a single protein) is crucial in multicellular organisms, where it prevents cancer formation, thus, functions as a tumor suppressor. As such, p53 has been described as ""the guardian of the genome"" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.The name p53 was given in 1979 describing the apparent molecular mass; SDS-PAGE analysis indicates that it is a 53-kilodalton (kDa) protein. In addition to the full length protein, the human TP53 gene encodes at least 15 protein isoforms, ranging in size from 3.5 to 53 kDa. All these p53 proteins are called the p53 isoforms.The International Cancer Genome Consortium has established that the TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation.TP53 gene encodes proteins that bind to DNA and regulate gene expression to prevent mutations of the genome.