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... • When it detects harmful substances called antigens • Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals Antibodies may be produced when the immune system mistakenly considers healthy tissue a harmful substance. This is called an autoimmune ...
... • When it detects harmful substances called antigens • Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals Antibodies may be produced when the immune system mistakenly considers healthy tissue a harmful substance. This is called an autoimmune ...
Monoclonal Antibodies
... Producing Monoclonal Antibodies 5. Add polyethylene glycol – this causes some Blymphocytes to fuse with tumour cells to produce a hybrid cell called a hybridoma. 6. Grow the cells under conditions that allow only hybridoma cells to survive. 7. Extract the cells, culture them separately and test the ...
... Producing Monoclonal Antibodies 5. Add polyethylene glycol – this causes some Blymphocytes to fuse with tumour cells to produce a hybrid cell called a hybridoma. 6. Grow the cells under conditions that allow only hybridoma cells to survive. 7. Extract the cells, culture them separately and test the ...
Monoclonal Antibodies
... Producing Monoclonal Antibodies 5. Add polyethylene glycol – this causes some Blymphocytes to fuse with tumour cells to produce a hybrid cell called a hybridoma. 6. Grow the cells under conditions that allow only hybridoma cells to survive. 7. Extract the cells, culture them separately and test the ...
... Producing Monoclonal Antibodies 5. Add polyethylene glycol – this causes some Blymphocytes to fuse with tumour cells to produce a hybrid cell called a hybridoma. 6. Grow the cells under conditions that allow only hybridoma cells to survive. 7. Extract the cells, culture them separately and test the ...
Immunoglobulins - Khyber Girls Medical College
... ◦ There is a much larger amount of IgG made than IgM, although IgM is first to be made in the secondary response. ◦ This is due primarily to the “memory” B-cells that were formed during the primary response. ◦ This is the basis for the concept of vaccination as well ...
... ◦ There is a much larger amount of IgG made than IgM, although IgM is first to be made in the secondary response. ◦ This is due primarily to the “memory” B-cells that were formed during the primary response. ◦ This is the basis for the concept of vaccination as well ...
Indezine Template
... What’s happening • Pathogen enters bloodstream • Survives host immune system • Invades Blood Brain Barrier (BBB) • Science not sure how it ...
... What’s happening • Pathogen enters bloodstream • Survives host immune system • Invades Blood Brain Barrier (BBB) • Science not sure how it ...
Missing genetic link found in a challenging immune disease
... include rheumatoid arthritis, stomach and bowel disorders, and autoimmune thrombocytopenia, a bleeding disorder. B-cell defects may also raise the risk of a type of lymphoma. Thus many CVID patients may develop symptoms resulting from an In the largest genetic study to date of a challenging admixtur ...
... include rheumatoid arthritis, stomach and bowel disorders, and autoimmune thrombocytopenia, a bleeding disorder. B-cell defects may also raise the risk of a type of lymphoma. Thus many CVID patients may develop symptoms resulting from an In the largest genetic study to date of a challenging admixtur ...
Chapter 3
... Most antigens offer multiple epitopes However, a single B cell will only produce antibody specific to single epitope Antibodies found in serum are from many different B cells ...
... Most antigens offer multiple epitopes However, a single B cell will only produce antibody specific to single epitope Antibodies found in serum are from many different B cells ...
Advances in Immunotherapy: Abhijit Guha Award Presentation
... Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina Correspondence: John H. Sampson, MD, PhD, MBA, Department of Neurosurgery, Duke University Medical Center, DUMC 3050, Durham, NC 27710. E-mail: john.sampson@duke.edu ...
... Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina Correspondence: John H. Sampson, MD, PhD, MBA, Department of Neurosurgery, Duke University Medical Center, DUMC 3050, Durham, NC 27710. E-mail: john.sampson@duke.edu ...
Guillain-Barre Syndrome
... resembles self protein. Damage results from “friendly fire” The inciting Ag is usually unidentified & may not exist as a single stimulus. • Excessive cytokine release due to profound immune stimulus may awaken self tolerant T cells or may cause expression of MHC complexes. • Self Ags bound to drugs ...
... resembles self protein. Damage results from “friendly fire” The inciting Ag is usually unidentified & may not exist as a single stimulus. • Excessive cytokine release due to profound immune stimulus may awaken self tolerant T cells or may cause expression of MHC complexes. • Self Ags bound to drugs ...
Cells of the Nervous System: The “Typical” Neuron Multipolar Neuron
... • Prevalence correlated with distance from equator (e.g. more common in northern states) – risk related to where you spent your childhood • Perhaps northern regions associated with higher exposure to illness during cold months? Perhaps certain bacteria/virus carry proteins similar to a myelin protei ...
... • Prevalence correlated with distance from equator (e.g. more common in northern states) – risk related to where you spent your childhood • Perhaps northern regions associated with higher exposure to illness during cold months? Perhaps certain bacteria/virus carry proteins similar to a myelin protei ...
ABO AND RH SYSTEM (Blood Grouping) • LEARNING OBJECTIVE
... Found in other tissue- kidney, liver, lungs Prevalence: O- 47% A- 41% B- 9% AB- 3% ...
... Found in other tissue- kidney, liver, lungs Prevalence: O- 47% A- 41% B- 9% AB- 3% ...
Hygiene hypothesis and allergic pathologies
... experienced a twin epidemic of multiple sclerosis and type I diabetes, both autoimmune diseases, in the past sixty years—ever since they got rid of malaria. For the past few thousand years, those Sardinians that were genetically resistant to the malaria parasite survived; those that were not did not ...
... experienced a twin epidemic of multiple sclerosis and type I diabetes, both autoimmune diseases, in the past sixty years—ever since they got rid of malaria. For the past few thousand years, those Sardinians that were genetically resistant to the malaria parasite survived; those that were not did not ...
Autoimmunity and autoinflammation
... Understanding autoimmune diseases Autoimmune diseases arise when your immune system mistakenly identifies your body’s own cells as foreign and attacks tissues that it would normally ignore, causing damage to them, as well as changes to organs and the way they function and grow. In the majority of ca ...
... Understanding autoimmune diseases Autoimmune diseases arise when your immune system mistakenly identifies your body’s own cells as foreign and attacks tissues that it would normally ignore, causing damage to them, as well as changes to organs and the way they function and grow. In the majority of ca ...
Autoimmune Diseases
... -↑ intrathecal Ab’s (oligoclonal bands), but no specific Ag identified -β-interferons effective in ↓ severity & frequency of exacerbations -interfere w/actions of interferon gamma, which provokes exacerbations -binds specific cell receptorssynthesis of >24 proteins that contribute to viral resistan ...
... -↑ intrathecal Ab’s (oligoclonal bands), but no specific Ag identified -β-interferons effective in ↓ severity & frequency of exacerbations -interfere w/actions of interferon gamma, which provokes exacerbations -binds specific cell receptorssynthesis of >24 proteins that contribute to viral resistan ...
Inflammatory CNS disease
... Inflammatory CNS disease Inflammatory CNS disease is a broad term used to describe a number of conditions causing inflammation of the central nervous system (from here on referred to as CNS). Depending on which part of the CNS is inflamed, inflammatory CNS disease can be more precisely divided into ...
... Inflammatory CNS disease Inflammatory CNS disease is a broad term used to describe a number of conditions causing inflammation of the central nervous system (from here on referred to as CNS). Depending on which part of the CNS is inflamed, inflammatory CNS disease can be more precisely divided into ...
Word version of this scenario
... Anatomy of the brain Pathophysiology of delirium and dementia Microbiology of herpes simplex virus Role of drug intoxication and withdrawal in altered mental states Awareness of nutritional deficiencies and how this may compound certain presentations e.g. delirium tremens Pharmacology of haloperidol ...
... Anatomy of the brain Pathophysiology of delirium and dementia Microbiology of herpes simplex virus Role of drug intoxication and withdrawal in altered mental states Awareness of nutritional deficiencies and how this may compound certain presentations e.g. delirium tremens Pharmacology of haloperidol ...
3 - Austin Community College
... Relates the increased frequency of autoantibodies and increased immune system deficiency to age. Mutation or loss of immune regulatory powers results in the condition in which self antigens behave as foreign antigens. ...
... Relates the increased frequency of autoantibodies and increased immune system deficiency to age. Mutation or loss of immune regulatory powers results in the condition in which self antigens behave as foreign antigens. ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
... LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 M.Sc. DEGREE EXAMINATION – BIOMEDICAL INSTRUMENTATION THIRD SEMESTER – NOV 2006 AG 11 ...
... LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 M.Sc. DEGREE EXAMINATION – BIOMEDICAL INSTRUMENTATION THIRD SEMESTER – NOV 2006 AG 11 ...
Autoimmunity and Autoimmune Diseases
... • Classified based on the effector mechanisms that appear to be most responsible for organ damage: – Autoantibodies – T-cells ...
... • Classified based on the effector mechanisms that appear to be most responsible for organ damage: – Autoantibodies – T-cells ...
Research synopsis - Corey Smith QIMR
... Dr Corey Smith – Queensland Institute of Medical Research Developing a vaccine strategy to treat EpsteinBarr Virus (EBV) associated Hodgkin’s lymphoma The primary aim of this research is to develop an immunotherapy approach that can be used to treat patients with Epstein-Barr Virus (EBV) associated ...
... Dr Corey Smith – Queensland Institute of Medical Research Developing a vaccine strategy to treat EpsteinBarr Virus (EBV) associated Hodgkin’s lymphoma The primary aim of this research is to develop an immunotherapy approach that can be used to treat patients with Epstein-Barr Virus (EBV) associated ...
misdirected reactions of the immune system autoimmunity
... * Effector mechanisms • Autoantibodies to many autoantigens • Most common autoantibody is to ds-DNA • Immune complex deposition on basement membranes with complement activation and inflammation ...
... * Effector mechanisms • Autoantibodies to many autoantigens • Most common autoantibody is to ds-DNA • Immune complex deposition on basement membranes with complement activation and inflammation ...
Orvosi biotechnológia Rekombináns fehérje alapú gyógyszerek
... Tumor targeting ‘Magic bullets’ can be created from monospecific antibodies (or derivatives) by chemically cross-linking toxic substances to Ig molecules. These drugs are targeted, increasing efficiency and lowering side effects ...
... Tumor targeting ‘Magic bullets’ can be created from monospecific antibodies (or derivatives) by chemically cross-linking toxic substances to Ig molecules. These drugs are targeted, increasing efficiency and lowering side effects ...
Recognition of Antigens
... Earliest experimental demonstrations of adaptive immunity was the finding by von Behring and Kitasato in 1890 that chemically inactivated toxins could induce protective immunity when injected into experimental animals, and that protection could be transferred to other susceptible animals by injectin ...
... Earliest experimental demonstrations of adaptive immunity was the finding by von Behring and Kitasato in 1890 that chemically inactivated toxins could induce protective immunity when injected into experimental animals, and that protection could be transferred to other susceptible animals by injectin ...