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Complement in skin diseases
Complement in skin diseases

... the classical pathway is defective. Most patients have a similar clinical picture to systemic or discoid lupus erythematosus. The discoid form is mostly accom- ...
View 2005 Investigator Meeting Presentation
View 2005 Investigator Meeting Presentation

... OD650 ...
Prostatitis and male UTI
Prostatitis and male UTI

... VB1 = urethral specimen – first 10 ml VB2 = MSU VB3 = post-massage specimen – first 10 ml after massage Type II (chronic bacterial prostatitis) diagnosed if 10 fold increase in bacteria when EPS/VB3 compared with VB1/VB2 [NB. if MSU positive, requires treatment of male UTI, followed by repeat locali ...
Assessment of the need for notification of
Assessment of the need for notification of

... short-term illness, &/or complete recovery in majority of cases, &/or case-fatality 0% short - longer-term illness, &/or lengthy recovery in some cases, &/or case-fatality <10% long-term disability, &/or recovery rare, &/or death more likely, &/or case-fatality 1-10% severe illness, and/or death is ...
Group B Streptococcal Disease: From Trials and
Group B Streptococcal Disease: From Trials and

... women during pregnancy [12] and to babies after delivery [13], but the most promising results involved use of antibiotic prophylaxis intrapartum, which is defined here as after onset of labor or rupture of the amniotic membranes. ...
Absence of cellular responses to a putative autoantigen in
Absence of cellular responses to a putative autoantigen in

... for bleeding and ocular examination. One hundred seventeen persons infected with O. volvulus were recruited (INF group). Selection was based on data compiled as part of a community-based study of the efficacy of the macrofilaricidal drug amocarzine. Detailed parasitologic and ophthalmologic informat ...
Will There Ever Be An Accurate Test for Lyme Disease?
Will There Ever Be An Accurate Test for Lyme Disease?

... Lyme Disease is a complex systemic disease that is caused by highly motile bacterium in the spirochete family. The bacteria Borrelia burgdorferi was first isolated from the skin of a Lyme patient with the distinctive bull’s-eye rash in the early 1980s. Since that time, culturing the elusive bacteriu ...
“Best o Best o f DDW” f DDW
“Best o Best o f DDW” f DDW

... 4.5mg/d in adults with CDAI >220, single crossover a baseline, Weeks 12 and 24 • Colonoscopies performed at • Primary outcomes: CDAI, endoscopic e and histologic ...
Understanding Autoimmune Disease – a review article for the layman
Understanding Autoimmune Disease – a review article for the layman

... responses to self-structures. This has fascinated researchers since the original theoretical description thereof in 1901. Autoimmunity is a necessary process of the immune regulatory networks in the body which need to sustain the body’s health. It is yet unknown fully why autoimmunity sometimes prog ...
A new perspective on COPD exacerbations: monitoring impact by measuring physical,
A new perspective on COPD exacerbations: monitoring impact by measuring physical,

... emphasise that physical resilience will play an important role in recovery following exacerbations. It seems also very reasonable to hypothesise that psychological and social resilience play an important role in the impact of an exacerbation of COPD [19]. Indeed, a defect in the challenge response r ...
Treatment of Mooren`s ulcer with cyclosporin A: report of three cases
Treatment of Mooren`s ulcer with cyclosporin A: report of three cases

... antigen binding."5 The efficacy of CSA in animal models of autoimmune diseases has been summarised by Borel.'6 While some animal models of autoimmunity were improved by CSA therapy, others deteriorated. Published studies of the efficacy of CSA in human autoimmune diseases are limited, but promising ...
Rituximab: An Autoimmune Disease Therapy
Rituximab: An Autoimmune Disease Therapy

... significant blistering of the skin and mucous membranes due to antibody formation against the proteins that join skin cells together. Blisters may form anywhere on the body, including the mouth and throat. Standard treatment for pemphigus includes high-dose oral steroids (prednisone) and/or an immun ...
C7. Time schedule of the research plan solution
C7. Time schedule of the research plan solution

... its high standards and its status on an international level. A few internationally respected groups work at the 2nd Medical Faculty - Charles University, both in the field of basic and applied clinical research. The quality is also enhanced by our success in getting grants financed by various grant ...
Celiac Disease, Inflammation and Oxidative Damage: A
Celiac Disease, Inflammation and Oxidative Damage: A

... capacity to trigger immunological reactions in CD patients [17]. Both types of activity in celiac disease are possible if there is defective digestion of the active peptides. As far as concerns the serine-containing peptides (Ser or S), their activity is linked to the presence of PSQQ and QQQP motif ...
Introduction Tuberculosis (TB) is a global public health hazard. Out
Introduction Tuberculosis (TB) is a global public health hazard. Out

... from the patient is the mainstay for the diagnosis of the tuberculosis; however, this is not always feasible in children because they rarely produce sputum and hence microscopic demonstration of the bacilli in the sputum yields mostly negative results [4]. Moreover, in most of the children the tuber ...
Resolvigen 3
Resolvigen 3

... When antibodies are so weak that they fail to react with some of the homozygous test RBCs, giving what appears to be spurious reactions; in this case the most likely match is found and the related antibody specificities suggested, hinting at procedures for confirming them. Varying reaction scores of ...
Low Dose Naltrexone and Autoimmune Diseases: Emerging
Low Dose Naltrexone and Autoimmune Diseases: Emerging

... Naltrexone and Autoimmune Disorders Understanding the exact mechanism by which naltrexone helps people with autoimmune disorders will be impossible to do until there are more studies done. For now there are a few different theories about why naltrexone works for autoimmune disorders. Naltrexone bloc ...
Vitamin D Concentrations are Decreased in Patients with Alopecia
Vitamin D Concentrations are Decreased in Patients with Alopecia

... diseases. It was reported that 1,25(OH)2D3 effects the immune system and low concentrations are associated with autoimmune disorders [16]. The associations between serum concentrations of 25(OH)-D and various autoimmune diseases such as multiple sclerosis, sistemic lupus erythematosus, romatoid arth ...
as a PDF
as a PDF

... In contrast to demyelination little attention in MS research has been paid to the problem of axonal pathology. From pathological studies it is evident, that the extent and severity of the in¯ammatory reaction is to some extent related to the amount of axonal damage.63,64 As an example, the most exte ...
`Protozoan` infections in the immunocompromised patient
`Protozoan` infections in the immunocompromised patient

... regimen of corticosteroids and low-protein diet (Walzer et al., 1980). It seems likely that asymptomatic infections in man become patent by similar mechanisms when the host becomes immunocompromised. As P. carinii pneumonitis has been described in patients with virtually any condition which reduces ...
Rheumatoid Arthritis
Rheumatoid Arthritis

... Rheumatoid Arthritis (RA) Fast facts • PREVALENCE : An estimated 1.5 million adults in the United States have rheumatoid arthritis. Affects 0.5-1.0% of population • Women are two to three times as likely to be affected as men. • Rheumatoid arthritis (RA) is an inflammatory systemic disease, with th ...
Predictive, Preventive and Personalized Medicine
Predictive, Preventive and Personalized Medicine

... Autoimmune diseases are the third leading cause of morbidity and mortality in the industrialized world! Most of the autoimmune diseases follow a chronic course that can be compared with a lengthy train ride. And a substantial need does exist for developing and validating a range of biomarkers that w ...
sympathetic ophthalmia: visual results with modern
sympathetic ophthalmia: visual results with modern

... or greater at review; only one saw less than 6/60 but this ...
Lyme Disease: The Facts, The Challenge
Lyme Disease: The Facts, The Challenge

... As infection spreads, rashes can appear at different sites on the body. Erythema migrans is often accompanied by symptoms such as fever, headache, stiff neck, body aches, and fatigue. Although these flu-like symptoms may resemble those of common viral infections, Lyme disease symptoms tend to persis ...
Amr Mustafa Abdelhamid Alhammady_338_IJAR
Amr Mustafa Abdelhamid Alhammady_338_IJAR

... Patients with decompensated liver cirrhosis have significantly impaired synthetic function. Many proteins involved in the coagulation process are synthesized in the liver.(24) Liver production of coagulation factors 1, 2, 5, 7, 9 and 10 which is reduced in chronic liver disease. Factors 2, 7, 9 and ...
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Neuromyelitis optica

Neuromyelitis optica (NMO), also known as Devic's disease or Devic's syndrome, is a heterogeneous condition consisting of the simultaneous inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis). It can be monophasic or recurrent.Currently at least two different causes are proposed based on the presence of autoantibodies against AQP4. AQP4+ NMO is currently considered an autoimmune disease (autoimmune astrocytopathy, or autoimmune astrocytic channelopathy) in which a person's own immune system attacks the astrocytes of the optic nerves and spinal cord. The cause of the AQP4- variants is unknown.Although inflammation may also affect the brain, the lesions are different from those observed in the related condition, multiple sclerosis. Spinal cord lesions lead to varying degrees of weakness or paralysis in the legs or arms, loss of sensation (including blindness), and/or bladder and bowel dysfunction.Devic's disease is now studied along a collection of similar diseases called ""Neuromyelitis optica spectrum diseases"". Some cases of this spectrum resemble multiple sclerosis (MS) in several ways, but require a different course of treatment for optimal results.In 2004, NMO-IgG (currently known as Anti-AQP IgG) was first described leading to the distinction between positive and negative cases.In Anti-AQP positive variants, CNS astrocytes, which are the basis for the glymphatic system are the target of the autoimmune attack. NMO-IgG-negative cases are less understood. It seems currently that astrocytes are spared in these IgG negative cases
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