Is host lipidation of pathogen effector proteins a general virulence
... Eukaryotic cells encode many proteins pathogens could represent a conserved virubearing cysteine as the fourth to last lence strategy. The Dot/Icm type IV secreresidue (Clarke et al., 1988). Indeed, a tion of L. pneumophila translocates AnkB. consensus sequence designated CAAX The group of Abu Kwai ...
... Eukaryotic cells encode many proteins pathogens could represent a conserved virubearing cysteine as the fourth to last lence strategy. The Dot/Icm type IV secreresidue (Clarke et al., 1988). Indeed, a tion of L. pneumophila translocates AnkB. consensus sequence designated CAAX The group of Abu Kwai ...
Cell Analogy to Hospitals - APBiology2015-2016
... inside the cell and will interfere with the functions of other organelles, causing chaos. ...
... inside the cell and will interfere with the functions of other organelles, causing chaos. ...
Extrapolating Anfinsen`s conclusions…
... original activity (~1%). The fact that 100% activity was achieved when sufficient time was allowed indicates that correct disulfide bond formation is favoured when correct folding takes place. Disulfide bonds are not essential for correct folding but they do stabilise the protein once it is folded. ...
... original activity (~1%). The fact that 100% activity was achieved when sufficient time was allowed indicates that correct disulfide bond formation is favoured when correct folding takes place. Disulfide bonds are not essential for correct folding but they do stabilise the protein once it is folded. ...
Quality Control
... fluorescence. Each lane contains lysates from ~40,000 cells. (B) Two-parameter FACS profiles of HEK cells transfected with GFP, Q25GFP, or Q103-GFP. GFP fluorescence is plotted against DNA content (propidium iodide fluorescence). The fluorescence signals in the two channels are indicated by pseudoco ...
... fluorescence. Each lane contains lysates from ~40,000 cells. (B) Two-parameter FACS profiles of HEK cells transfected with GFP, Q25GFP, or Q103-GFP. GFP fluorescence is plotted against DNA content (propidium iodide fluorescence). The fluorescence signals in the two channels are indicated by pseudoco ...
Gene Section GRPR (Gastrin-Releasing Peptide Receptor) Atlas of Genetics and Cytogenetics
... chromosome and the GRP-R has 7 transmembrane (TM) domains, an extracellular N-terminal and intracellular C-terminal. Exon 1 codes for TM 1, 2 and 3 domains with splice site in IC loop 2 (Asp137). Exon 2 codes for TM 4 and 5 with a Gln255 splice site. Exon 3 codes for TM 6-7 domains and the cytoplasm ...
... chromosome and the GRP-R has 7 transmembrane (TM) domains, an extracellular N-terminal and intracellular C-terminal. Exon 1 codes for TM 1, 2 and 3 domains with splice site in IC loop 2 (Asp137). Exon 2 codes for TM 4 and 5 with a Gln255 splice site. Exon 3 codes for TM 6-7 domains and the cytoplasm ...
Structures of Proteins Primary structure
... Vitamin B12 is used in the body in two forms: Methylcobalamin and 5deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation ...
... Vitamin B12 is used in the body in two forms: Methylcobalamin and 5deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation ...
BIOLOGY 311C - Brand Spring 2007 NAME (printed very legibly
... a. CO2 and ATP. b. sugar and NADH. c. ATP and NADPH. d. ADP and NADP+. 32. The CO2-fixing enzyme, rubisco, also uses a non-productive reactant, which causes photorespiration. This non-productive substrate is: a. NH4+ . b. N2 . c. HCO3 -. d. O2 . 33. CAM plants differ from normal C3 plants in that CA ...
... a. CO2 and ATP. b. sugar and NADH. c. ATP and NADPH. d. ADP and NADP+. 32. The CO2-fixing enzyme, rubisco, also uses a non-productive reactant, which causes photorespiration. This non-productive substrate is: a. NH4+ . b. N2 . c. HCO3 -. d. O2 . 33. CAM plants differ from normal C3 plants in that CA ...
Slide - Linked Science
... Use case1: Extraction of Protein-Protein Interaction Based on Domain-Domain Interactions Let’s Assume a single protein e.g. HES1 Q1: What are the potential interacting partners? What we know: It contains a protein domain called Hairy_orange We know Hairy_orange’s interacting domains ...
... Use case1: Extraction of Protein-Protein Interaction Based on Domain-Domain Interactions Let’s Assume a single protein e.g. HES1 Q1: What are the potential interacting partners? What we know: It contains a protein domain called Hairy_orange We know Hairy_orange’s interacting domains ...
Bacterial Rhodopsin Light-driven Proton Pump
... 1. Retinal (VitA aldehyde or retinaldehyde; one of 3 forms of VitA) is parallel to the plane of the membrane, bound to K216 in the middle of helix 7. 2. The internal cavity is divided into two half channels, cytoplasmic and external (the H+ pathway) 3. The internal half channel is more hydrophobic. ...
... 1. Retinal (VitA aldehyde or retinaldehyde; one of 3 forms of VitA) is parallel to the plane of the membrane, bound to K216 in the middle of helix 7. 2. The internal cavity is divided into two half channels, cytoplasmic and external (the H+ pathway) 3. The internal half channel is more hydrophobic. ...
Protein Kinases - School of Medicine
... attracts proteins via SH2 domains • Proteins that (may) dock with P-Tyr via SH2 domains: PLC, PI3 kinase, Shc, Grb-2, and many others – Not all RPTKs associate with all SH2-containing proteins ...
... attracts proteins via SH2 domains • Proteins that (may) dock with P-Tyr via SH2 domains: PLC, PI3 kinase, Shc, Grb-2, and many others – Not all RPTKs associate with all SH2-containing proteins ...
Cell Structures
... The inside of eukaryotic and prokaryotic cells also both contain a jelly-like substance called cytosol. Cytosol is composed of water and other molecules, including enzymes that speed up the cell’s chemical reactions. Everything ...
... The inside of eukaryotic and prokaryotic cells also both contain a jelly-like substance called cytosol. Cytosol is composed of water and other molecules, including enzymes that speed up the cell’s chemical reactions. Everything ...
2. Fill in: Phospholipids have their
... membrane is _______________ which stabilizes membrane fluidity. The proteins found in the plasma membrane may be ____________ proteins, which penetrate the membrane, or _____________ proteins, which occur either on the cytoplasmic side or the outer surface side of the membrane. 3. Place an "X" next ...
... membrane is _______________ which stabilizes membrane fluidity. The proteins found in the plasma membrane may be ____________ proteins, which penetrate the membrane, or _____________ proteins, which occur either on the cytoplasmic side or the outer surface side of the membrane. 3. Place an "X" next ...
Time constants
... in what relative proportions. It turns out that each population of neurons has multiple types of receptor; in other words, most neurons have both NMDA and non-NMDA glutamate receptors, as well as GABAA and GABAB receptors. Quantitative estimates of receptor distribution are usually studied through t ...
... in what relative proportions. It turns out that each population of neurons has multiple types of receptor; in other words, most neurons have both NMDA and non-NMDA glutamate receptors, as well as GABAA and GABAB receptors. Quantitative estimates of receptor distribution are usually studied through t ...
Microbial Cell Surfaces and Secretion Systems
... The membrane-spanning segments are not α-helices but β-strands, which form a βbarrel (Fig. 6.1). These β-strands are amphipathic with hydrophobic residues facing the lipids and hydrophilic ones directed toward the interior of the barrel. Some of these β-barrels form open channels through which small ...
... The membrane-spanning segments are not α-helices but β-strands, which form a βbarrel (Fig. 6.1). These β-strands are amphipathic with hydrophobic residues facing the lipids and hydrophilic ones directed toward the interior of the barrel. Some of these β-barrels form open channels through which small ...
education - Perelman School of Medicine
... My doctoral thesis research focused on understanding domain-specific function of the nuclear pore protein, Nup153. Specifically, biosensor experiments and structural and chemical shift analysis via NMR were used to examine the interaction between the zinc finger domain of Nup153 and the small GTPase ...
... My doctoral thesis research focused on understanding domain-specific function of the nuclear pore protein, Nup153. Specifically, biosensor experiments and structural and chemical shift analysis via NMR were used to examine the interaction between the zinc finger domain of Nup153 and the small GTPase ...
Psychology Lecture 02 - Biological Basis
... Cerebral Cortex divided into lobes, or regions of the brain ◦ Each lobe is (roughly) responsible for different higher-level functions, but remember that they do not work merely in isolation. ...
... Cerebral Cortex divided into lobes, or regions of the brain ◦ Each lobe is (roughly) responsible for different higher-level functions, but remember that they do not work merely in isolation. ...
Describe in simple terms the chemical nature of sugars, proteins
... Describe in simple terms the chemical nature of sugars, proteins, lipids, nucleotides and enzymes: Sugars – a simple sugar, known as a monosaccharide, is made up of 3 to 7 carbon atoms arranged in a ring. A disaccharide is two monosaccharides, such as glucose and fructose equals sucrose. A polysacch ...
... Describe in simple terms the chemical nature of sugars, proteins, lipids, nucleotides and enzymes: Sugars – a simple sugar, known as a monosaccharide, is made up of 3 to 7 carbon atoms arranged in a ring. A disaccharide is two monosaccharides, such as glucose and fructose equals sucrose. A polysacch ...
job description
... Being able to demonstrate a strong ability to develop target binding (e.g. ELISA, MSD, Alpha-screen and/or HTRF) and phenotypic based assays (phosphorylation, cell proliferation etc.) using a range of techniques (e.g. Western blot, flow cytometry, confocal microscopy and IHC) ...
... Being able to demonstrate a strong ability to develop target binding (e.g. ELISA, MSD, Alpha-screen and/or HTRF) and phenotypic based assays (phosphorylation, cell proliferation etc.) using a range of techniques (e.g. Western blot, flow cytometry, confocal microscopy and IHC) ...
Cells Alive - White Plains Public Schools
... Navigating the site: Cellsalive.com has a navigation bar at the left. After accessing the page, click on CELL BIOLOGY on the left side navigation bar. From here, you will access the links: "How Big is a..", the animal cell model, the plant cell model, and the bacterial cell model. ...
... Navigating the site: Cellsalive.com has a navigation bar at the left. After accessing the page, click on CELL BIOLOGY on the left side navigation bar. From here, you will access the links: "How Big is a..", the animal cell model, the plant cell model, and the bacterial cell model. ...
Section 10-2 Cell Division 3 reasons why cells divide instead of
... Internal regulators allow the cell cycle to proceed only when certain processes have happened inside the cell. External Regulators Proteins that respond to events outside the cell are called external regulators. External regulators direct cells to speed up or slow down the cell cycle. Growth factors ...
... Internal regulators allow the cell cycle to proceed only when certain processes have happened inside the cell. External Regulators Proteins that respond to events outside the cell are called external regulators. External regulators direct cells to speed up or slow down the cell cycle. Growth factors ...
BD Pharmingen™ FITC Rat Anti-Mouse Vβ 11 T
... The RR3-15 antibody reacts with the Vβ 11 T-Cell Receptor (TCR) of mice having the b haplotype (e.g., A, C57BL, C58, DBA/1) of the Tcrb gene complex. The Tcrb-V11 gene locus is deleted in mice having the a (e.g., C57BR, C57L, SJL, SWR) and c (e.g., RIII) haplotypes. Vβ TCR-bearing T lymphocytes are ...
... The RR3-15 antibody reacts with the Vβ 11 T-Cell Receptor (TCR) of mice having the b haplotype (e.g., A, C57BL, C58, DBA/1) of the Tcrb gene complex. The Tcrb-V11 gene locus is deleted in mice having the a (e.g., C57BR, C57L, SJL, SWR) and c (e.g., RIII) haplotypes. Vβ TCR-bearing T lymphocytes are ...
05-Humoral_Immunity__Ig_structure_and_func_2008
... Block the active sites of toxins or pathogen-associated molecules ...
... Block the active sites of toxins or pathogen-associated molecules ...
Definition of a RACK1 Interaction Network in Drosophila
... Infectious diseases represent a major cause of death for animals, including humans. Among them, viral infections are particularly hard to treat because viruses replicate inside host cells. Many cellular proteins are hijacked by viruses to complete their replication cycle and represent putative targe ...
... Infectious diseases represent a major cause of death for animals, including humans. Among them, viral infections are particularly hard to treat because viruses replicate inside host cells. Many cellular proteins are hijacked by viruses to complete their replication cycle and represent putative targe ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.