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... of the APC/C substrates geminin, Plk1, and securinDD (Figure 1E). Moreover, injection of ubi-R11 into X. tropicalis embryos delays early cell divisions and results in death of injected embryos before gastrulation (Figures 1F and 1G). These phenotypes are less dramatic but similar to those observed a ...
... of the APC/C substrates geminin, Plk1, and securinDD (Figure 1E). Moreover, injection of ubi-R11 into X. tropicalis embryos delays early cell divisions and results in death of injected embryos before gastrulation (Figures 1F and 1G). These phenotypes are less dramatic but similar to those observed a ...
Manuscript_12122012_revised
... revealed concentration-dependent increase in the presence of TDM (Fig. 1). This was reflected in increased enhancement ratios (Fig. 1e,f), noting slightly higher ratios for the E12 monolayers than the Caco2 monolayers. 0.05% w/v TDM statistically increased the Papp for sCT and 3H-mannitol by ~50% ...
... revealed concentration-dependent increase in the presence of TDM (Fig. 1). This was reflected in increased enhancement ratios (Fig. 1e,f), noting slightly higher ratios for the E12 monolayers than the Caco2 monolayers. 0.05% w/v TDM statistically increased the Papp for sCT and 3H-mannitol by ~50% ...
P-Glycoprotein functional activity in peripheral blood lymphocytes. Role of immunosuppressants,
... resistance to a diverse range of compounds in tumor cells. ATPdependent drug efflux pump, P-glycoprotein (Pgp), has been the most widely studied regarding multidrug resistance in tumor cells [1-4]. Pgp was first described in hamster’s ovary tumor cells, preventing access of anticancer agents to cell ...
... resistance to a diverse range of compounds in tumor cells. ATPdependent drug efflux pump, P-glycoprotein (Pgp), has been the most widely studied regarding multidrug resistance in tumor cells [1-4]. Pgp was first described in hamster’s ovary tumor cells, preventing access of anticancer agents to cell ...
Life Sciences - Bharathiar University
... Nanoparticles can deliver drugs in a sophisticated ways, like target specific and trigger based drug dose. Target specific delivery enables the use of lower doses, because the whole body is not saturated with the drug. The side effects will be minimized, and it is possible to use stronger drug ...
... Nanoparticles can deliver drugs in a sophisticated ways, like target specific and trigger based drug dose. Target specific delivery enables the use of lower doses, because the whole body is not saturated with the drug. The side effects will be minimized, and it is possible to use stronger drug ...
Contributions of CYP3A4, P-glycoprotein, and Serum Protein
... due to a reduced unbound concentration of drug after it enters the portal circulation. The human intestinal cell line Caco-2 forms polarized monolayers that structurally resemble enterocytes (Meunier et al., 1995). Although these cells constitutively express several drug-metabolizing enzymes and tra ...
... due to a reduced unbound concentration of drug after it enters the portal circulation. The human intestinal cell line Caco-2 forms polarized monolayers that structurally resemble enterocytes (Meunier et al., 1995). Although these cells constitutively express several drug-metabolizing enzymes and tra ...
The functional relationship between ectodermal and mesodermal
... ectoteloblasts, while others do not. Moreover, the number of ectoteloblasts varies between species. Conservation of mesoderm segmentation is consistent with a critical developmental function, such as providing an instructive signal to the segmental ectoderm. To test the hypothesis that the mesoderm ...
... ectoteloblasts, while others do not. Moreover, the number of ectoteloblasts varies between species. Conservation of mesoderm segmentation is consistent with a critical developmental function, such as providing an instructive signal to the segmental ectoderm. To test the hypothesis that the mesoderm ...
Plakoglobin domains that define its association with the
... The linkage between the classical cadherins and the actin cytoskeleton via the catenins is better understood than the analogous connection of the desmosomal cadherins to the intermediate filament cytoskeleton. A short stretch of 37 amino acids in the C terminus of desmocollin-1 was recently shown by ...
... The linkage between the classical cadherins and the actin cytoskeleton via the catenins is better understood than the analogous connection of the desmosomal cadherins to the intermediate filament cytoskeleton. A short stretch of 37 amino acids in the C terminus of desmocollin-1 was recently shown by ...
Epithelium and mucus
... Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology Sahlgrenska Academy, University of Gothenburg, Sweden The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is ...
... Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology Sahlgrenska Academy, University of Gothenburg, Sweden The intestine is covered by mucus that is the first line of defence of the epithelium. The main structural component of the intestinal mucus is the MUC2 mucin. This is ...
Human Eosinophils from Transport-Mediated Release of Preformed
... in allergen-induced cutaneous late-phase reactions in atopic subjects (15, 19), human blood-derived eosinophils are a major potential source of IL-4. Because eosinophils contain preformed IL-4, the mechanisms to mobilize IL-4 from specific granule storage sites for its extracellular release need to ...
... in allergen-induced cutaneous late-phase reactions in atopic subjects (15, 19), human blood-derived eosinophils are a major potential source of IL-4. Because eosinophils contain preformed IL-4, the mechanisms to mobilize IL-4 from specific granule storage sites for its extracellular release need to ...
THE AMERICAN UNIVERSITY IN CAIRO School of Sciences and Engineering
... Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility and rapid ...
... Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility and rapid ...
Contrasting Actions of Lanthanum on Different Recombinant
... Multipuffer system to apply a range of different concentrations of drugs. To enable fast application of a number of different concentrations and types of drug, a multipuffer application system was designed in the laboratory (17). Briefly, it consisted of a T-tube device with inlet and outlet ports f ...
... Multipuffer system to apply a range of different concentrations of drugs. To enable fast application of a number of different concentrations and types of drug, a multipuffer application system was designed in the laboratory (17). Briefly, it consisted of a T-tube device with inlet and outlet ports f ...
Plant hormones and growth regulators
... 1956 ; Tagawa and Bonner, 1957 ). Strong support for the Ca2+/pectate interaction came from a quantitative examination of the cation exchange capacity of the coleoptile cell wall, which was shown to be due to the number of free pectic carboxyl groups (Jansen et al., 1960 ). Still further support cam ...
... 1956 ; Tagawa and Bonner, 1957 ). Strong support for the Ca2+/pectate interaction came from a quantitative examination of the cation exchange capacity of the coleoptile cell wall, which was shown to be due to the number of free pectic carboxyl groups (Jansen et al., 1960 ). Still further support cam ...
Collagen Diversity, Synthesis and Assembly
... cross-linked to both collagens II and XI in the cartilage fibril, through lysine-derived cross-links; recent studies have shown how flexibility within the non-collagenous domains allows these cross-links to form (Eyre et al., 2004). Strongest homology within the FACITs is in the C-terminal collageno ...
... cross-linked to both collagens II and XI in the cartilage fibril, through lysine-derived cross-links; recent studies have shown how flexibility within the non-collagenous domains allows these cross-links to form (Eyre et al., 2004). Strongest homology within the FACITs is in the C-terminal collageno ...
Induction and Fixation of Polarity -Early Steps in Plant Morphogenesis
... focus of scientific interest many years ago. Polarity was detected as a basoapical gradient in the capacity of root stocks to regenerate adventitious shoots. In addition, there is an antiparallel gradient in the capacity of the scion to regenerate adventitious roots (32). The earliest theory on shoo ...
... focus of scientific interest many years ago. Polarity was detected as a basoapical gradient in the capacity of root stocks to regenerate adventitious shoots. In addition, there is an antiparallel gradient in the capacity of the scion to regenerate adventitious roots (32). The earliest theory on shoo ...
Retention in the Golgi apparatus and expression on the cell surface
... juxtamembrane region destabilizes Cfr passed through the Golgi apparatus. This destabilization does not depend on the cleavage and secretion of the extracellular domain of Cfr. Furthermore, we ...
... juxtamembrane region destabilizes Cfr passed through the Golgi apparatus. This destabilization does not depend on the cleavage and secretion of the extracellular domain of Cfr. Furthermore, we ...
Receptor-regulated Dynamic S-Nitrosylation of Endothelial Nitric
... biotin switch analysis. For C, BAEC were preincubated for 60 min with L-NMA (5 mM) or vehicle and then incubated with VEGF (10 ng/ml) or its vehicle for an additional 60 min. eNOS was then harvested from the cells and processed by the biotin switch method. The blot shown is representative of three i ...
... biotin switch analysis. For C, BAEC were preincubated for 60 min with L-NMA (5 mM) or vehicle and then incubated with VEGF (10 ng/ml) or its vehicle for an additional 60 min. eNOS was then harvested from the cells and processed by the biotin switch method. The blot shown is representative of three i ...
View - Max-Planck
... that can be used by the cell. This energy then powers a series of reactions that result in carbon dioxide being incorporated into energy-rich sugars. The enzyme RuBisCO is essential for this process, and is believed to be the most abundant protein on Earth. In land plants, RuBisCO is found throughou ...
... that can be used by the cell. This energy then powers a series of reactions that result in carbon dioxide being incorporated into energy-rich sugars. The enzyme RuBisCO is essential for this process, and is believed to be the most abundant protein on Earth. In land plants, RuBisCO is found throughou ...
Boik-Natural-Compounds-in-Cancer-Therapy-Promising
... from the human trials, is promising. And the most crucial point, central to this book, is that the beneficial effects of these compounds are likely to be much more apparent when they are used in large combinations, permitting additive and synergistic interactions to occur. Second, although the futur ...
... from the human trials, is promising. And the most crucial point, central to this book, is that the beneficial effects of these compounds are likely to be much more apparent when they are used in large combinations, permitting additive and synergistic interactions to occur. Second, although the futur ...
Spatial Reorganization of Glycogen Synthase upon Activation in 3T3
... enzymatic activation was not in itself sufficient to promote glycogen synthase translocation. However, acute insulin treatment consistently increased glycogen synthase immunostaining in 3T3-L1 adipocytes incubated in 2-DG-containing media (Fig. 2). The reason for this result is not clear, but it may ...
... enzymatic activation was not in itself sufficient to promote glycogen synthase translocation. However, acute insulin treatment consistently increased glycogen synthase immunostaining in 3T3-L1 adipocytes incubated in 2-DG-containing media (Fig. 2). The reason for this result is not clear, but it may ...
fulltext
... disposal have resulted in an increasing demand for replacement of different petroleum-based products with renewable bio-based materials. Biopolymers are one of the most important groups of renewable materials. In order to reduce the waste problems, biodegradability seems to be an essential property ...
... disposal have resulted in an increasing demand for replacement of different petroleum-based products with renewable bio-based materials. Biopolymers are one of the most important groups of renewable materials. In order to reduce the waste problems, biodegradability seems to be an essential property ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.