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Emerging biological roles of Cl− intracellular channel proteins
Emerging biological roles of Cl− intracellular channel proteins

... Rho-regulated cortical actin dynamics as well as vesicular trafficking and integrin recycling, the latter of which are under the control of Rab GTPases. In this Commentary, we discuss the emerging roles of CLIC proteins in these processes and the lessons learned from genetargeting studies. We also h ...
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... INTRODUCTION: Intervertebral disc (IVD) degeneration is a leading cause of low back pain (LBP), a common and often debilitating condition associated with an estimated annual cost of over $100 billion.1,2 As humans age, the IVD becomes more susceptible to degeneration due to compositional and subsequ ...
Immunoglobulin Heavy Chain and Binding Protein Complexes Are
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Intercellular communication in the early embryo of
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Stimulation of Klotho and AMPK activity to mimic caloric restriction
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Full Text  - Journal of Skin and Stem Cell
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... o They wrap around each other because the hydrophobic regions are covered up and then they interact with each other because of the + and – charges on the outside of the coiled coil. Slide 4:  The more repeats that I am talking about are the repeats that you see on the surface of the molecule that c ...
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Extracellular matrix



In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.The animal extracellular matrix includes the interstitial matrix and the basement membrane. Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest.The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicelluar biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).
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