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Genome-wide association studies for microbial genomes
Genome-wide association studies for microbial genomes

... – E.g. transcription factor – GO: Molecular function ...
Non-directed Modification of Genome Cont.. - PMAS
Non-directed Modification of Genome Cont.. - PMAS

... nucleases facilitate the process of genome editing.  Zinc finger nucleases – the first representatives of this technology – have been developed and improved for 20 years.  Nevertheless, some aspects of these technologies, including efficiency, decrease of off-target mutations, constructs generatio ...
Glossary of Terms - Liverpool Womens NHS Foundation Trust
Glossary of Terms - Liverpool Womens NHS Foundation Trust

... The functional and physical unit of heredity passes from parent and offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein. ...
problem set5
problem set5

... the same rate. This surprised the researcher because this gene is known to have an important function and mutants for this gene normally have low fitness. a. Why is the researcher surprised that synonymous and non-synonymous sites are evolving at similar rates? b. What is the expected dN/dS ratio fo ...
Gene Section IRF4 (interferon regulatory factor 4) Atlas of Genetics and Cytogenetics
Gene Section IRF4 (interferon regulatory factor 4) Atlas of Genetics and Cytogenetics

Summary sheet - ThinkChemistry
Summary sheet - ThinkChemistry

... The different cell components have different functions: Name of structure ...
- PWSA UK
- PWSA UK

... DNA includes approximately 40,000 genes that code for individual proteins, which are the building blocks of the body. Other parts of the DNA that are not coding for genes have important regulatory functions. The sequence of DNA is identical in all cells of any given person but quite normally varies ...
Original
Original

... Recombination – during meiosis – independent assortment & crossing over of genes on chromosomes, it’s when the genes are reshuffled. Random pairing of gametes – every organism makes so many gametes.. it’s random which ones will pair up ...
APgenetics0708
APgenetics0708

... because of delayed diagnosis and treatment of his disorder, known as phenylketonuria, or PKU. Those with PKU cannot metabolize a certain amino acid that is found in meats and dairy products. The Redwood City family sued the two medical facilities after learning that the Stanford Hospital medical sta ...
BIO-NMD: Discovery and validation of biomarkers for NMDs * an EU
BIO-NMD: Discovery and validation of biomarkers for NMDs * an EU

... Genetic neuromuscular diseases (NMD) have a wide phenotypic spectrum, show an enormous genetic heterogeneity, are usually incurable and can be associated with severe complications including sudden death. In the past 25 years the strategies and methods applied have allowed us to identify neuromuscula ...
Introduction to Next-Generation Sequence analysis
Introduction to Next-Generation Sequence analysis

... Each and everyone is a unique creation! Life’s little book of instructions DNA blue print of life! Human body has 1013 cells and each cell has 6 billion base pairs (A, C, G, T) • A hidden language/code determines which proteins should be made and when • This language is common to all organisms ...
Introduction to molecular biology…
Introduction to molecular biology…

... untranscribed region ...
Chapter 13 1. is when two parents give rise to an offspring that have
Chapter 13 1. is when two parents give rise to an offspring that have

... 2. ______________________ is the type of cell division in sexually reproducing organisms that results in cells with half the chromosome number of the original cell. This type of cell division only occurs in cells that make ______________________. In the life cycle of an organism, one _______________ ...
Lecture 6
Lecture 6

... – How would you test your hypothesis? ...
NonMendelian Inheritance PPT
NonMendelian Inheritance PPT

... • More than one set of genes coding for a trait (NOT the same as multiple alleles) • Eye color is influenced by many genes coding for different kinds of pigment as well as where in the iris those pigments are found (some have been located on ...
DNA Sequence Analysis for Epilepsy and Seizure
DNA Sequence Analysis for Epilepsy and Seizure

... The most comprehensive tests available for seizure disorders Knowing the genetic basis of a patient’s epilepsy is valuable for obtaining a definitive diagnosis, estimating prognosis, determining recurrence risks, and guiding treatment choices. In many cases, the precise genetic diagnosis can be impo ...
If you have BRCA in the family (Scotland)
If you have BRCA in the family (Scotland)

... is a BRCA1/2 gene mutation carrier and there is a strong possibility that this gene mutation will have been passed on to me. According to SIGN Guideline 3.2.2: “BRCA1 and BRCA2 mutation analysis should be considered in a family where there is a 10% or greater risk of mutations present” I am therefor ...
Recombinant DNA
Recombinant DNA

... • DNA technologies are used in molecular testing for many human genetic diseases • DNA fingerprinting used to identify human individuals and individuals of other species • Genetic engineering uses DNA technologies to alter the genes of a cell or organism • DNA technologies and genetic engineering ar ...
No Slide Title
No Slide Title

... – Chorionic Villi Sampling (CVS): from tissue between placenta & fetus, do karyotype ...
Ch. 10 DNA Review Questions
Ch. 10 DNA Review Questions

... a. The DNA in eukaryotic cells is very loosely packed. b. Prokaryotic cells contain more DNA than eukaryotic cells. c. A human cell contains more than 1 meter of DNA. d. The DNA of the smallest human chromosome is nearly 10 times as long as many bacterial chromosomes. ...
Say 2 significant things about these terms:
Say 2 significant things about these terms:

... - What are 4 different types of mutations? Give a drawing of each and state the examples or effects of these. - What is a vicariance event? Please give two examples. - Darwin knew two things about fitness and selection. What does this mean, what did he know about them? What did Darwin not know about ...
Researchers identify gene that helps plant cells keep
Researchers identify gene that helps plant cells keep

... This ROS threat, according to Jackson's team, is Source: Cold Spring Harbor Laboratory normally counter-balanced by GAT1. The CSHL scientists found that this gene encodes an enzyme called thioredoxin-m3, which they found only in the meristems, as well as in the tissues dedicated to transport. There, ...
Gene Set Testing - USU Math/Stat
Gene Set Testing - USU Math/Stat

... look at all possible re-arrangements of table values, keeping fixed marginal totals traditional: sample of subjects with fixed measurements here: sample of measurements from fixed samples ...
Genetics
Genetics

... Islamic University College of Nursing ...
Lesson Plans Teacher: Robinson Dates: 12:5
Lesson Plans Teacher: Robinson Dates: 12:5

... 1. Explain the steps of binary fission and identify what types of cells it occurs in. 2. How are binary fission, budding, and mitosis different? 3. Summarize the major events of the mitotic cell cycle 4. Justify how mitosis is used for growth (identical cells) and meiosis is for variation. 5. Differ ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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