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D. melanogaster
D. melanogaster

... discovery. For the moment, at least, that should be sufficient. At some point we will inevitably emerge into a clearing where principles and patterns in the organization and evolution of the genome are evident. Until then, let us be thankful that the pleasures of the forest are so numerous and diver ...
Investigating the Results of Inherited Traits
Investigating the Results of Inherited Traits

... of an individual that are based on its genotype is known as its phenotype. In humans, the male gene determines the sex of an individual. Individuals that have two X-chromosomes (XX) are females, while individuals with an X and Y chromosome (XY) are males. In this investigation you will observe how t ...
Map of the Human β-Globin Gene – In Brief
Map of the Human β-Globin Gene – In Brief

... Because the genetic code is triplet, there are three forward reading frames on a strand of DNA. Eukaryotic genes have gaps, called introns, which must be removed from the mRNA before the protein is made. The number of introns, and their length, varies with different genes. Errors in removing introns ...
S3.Cell Signaling-Signaling and gene expression
S3.Cell Signaling-Signaling and gene expression

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Summary Gene regulatory factors in the evolutionary history of
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No Slide Title
No Slide Title

... How boundaries between tissues are established  Boundaries between tissues can be created by different cell types having both different types and different amounts of cell-adhesion molecules  The most common cell-adhesion molecules are cadherins  Cadherins establish and maintain intercellular co ...
EVOLUTIONARY GENETICS (Genome 453) Practice problems for
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Genetics
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... categories: Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL) (DeVita et al., 2015). Different subtypes were described in current WHO classification (WHO, 2008), which is based on various biological and clinical features of the disease. In humans, 5.1 % of all cancer cases was diagnosed as NHL an ...
Unit 11 Human Genetics
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... The stage in the formation of male gametes in a plant in which haploid daughter cells are formed from a haploid parent cell. Cell division which takes place in the growth of a human testis between birth and five years of age. The stage in the lifecycle of a protoctistan in which a large number of ge ...
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No Slide Title

...  The gene for enzymes of metabolism or protein biosynthesis which proceed in all cells are transcribed more often  Most of the genes are switched off and are activated only in certain organ and then often only in certain cells  Many genes are only switched on at specific times ...
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... transmitted to all the cells of the offspring and may be significant for the future of the species. Somatic gene mutations which arise in the organism are inherited only by those cells derived from the mutant cells by mitosis. ...
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... Mutation is a constant problem. Many mechanisms prevent cells with seriously mutated DNA from dividing. Malignant cells usually undergo chromosomal rearrangements, leading to new fused genes and loss of heterozygosity. Spindle checkpoint. During mitosis, cells can only proceed into anaphase when all ...
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Identification and Chromosome Assignment of a Human Gene

... of genes have been identified that are similar to a large central portion of pi 10, but they differ from pi 10 at their N and C termini. Recently, several additional classes of PI3K have been identified, such as ATM, DNA-PKcs, FRAP and FRP1 that are involved in cell cycle regulation, checkpoint cont ...
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Ch. 17 DNA mutations and Repair

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Supplementary Information (doc 46K)
Supplementary Information (doc 46K)

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Bio 101 Homework 2 Prof. Fournier
Bio 101 Homework 2 Prof. Fournier

... B) The percentage of their proteins with the same molecular composition is high. C) The base sequences of their genes are identical. D) The mutation rate is the same in their body cells. This molecule controls cellular activity by directing the synthesis of A) carbohydrates C) fats ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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