• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Bio07_TR__U04_CH11.QXD
Bio07_TR__U04_CH11.QXD

... Probability can be used to predict the outcome of genetic crosses because alleles segregate randomly. The gene combinations that might result from a genetic cross can be determined by drawing a Punnett square. In a Punnett square, alleles are represented by letters. A capital letter represents the d ...
Unit 3 Practice Test
Unit 3 Practice Test

... ______21. One difference between mitosis and meiosis I is that a. homologous chromosome pairs form tetrads during mitosis. b. chromosomes do not replicate in the interphase preceding meiosis. c. homologous chromosome pairs form tetrads during meiosis but not during mitosis. d. sister chromatids sep ...
Teacher Guide
Teacher Guide

... There is no change in the speed of the rabbit from Lesson 5, but the energy lost by each rabbit depends on both color gene and temperature in this activity. At high temperatures the energy loss has a relatively linear dependence on color gene value (with low values having low energy loss and high v ...
Enzymes - year13bio
Enzymes - year13bio

... Substrate: the chemicals an enzyme acts on. Active site: the part of the enzyme where the substrate binds and where the reaction occurs. The active site has a specific shape so only specific substrates can bind. Nomenclature: ase ...
Expression Analysis of the Sphingolipid Metabolism
Expression Analysis of the Sphingolipid Metabolism

... through the visualization of gene expression data within a metabolic pathway. Expression data derived from microarray and other similar genomic experiments can be imported and recognized by GenMAPP using multiple gene identifiers such as Entrez Gene, Ensembl, and Affy ID's. This program allows for t ...
Human Genome Case Study
Human Genome Case Study

... bacteria millions of years ago. Whether the bacteria infected humans or they were carried by a virus is still unknown. uEvery human’s genome carries the residues of evolution, a history stretching back millions of years. The journals discuss these things and many more. Nature begins with a 68-page r ...
Final Exam 2007 key
Final Exam 2007 key

... bubble in your answers on the scantron. We will only grade the scantron so double check to be sure the answers on the scantron are as you want them. Through out the exam, please cover your answers. Do not use electronic gadgets, including telephone--so, please turn off your telephone prior to starti ...
PSYC 3102: Introduction to Behavioral Genetics
PSYC 3102: Introduction to Behavioral Genetics

...  Key idea: a large number of genes can be affected  Normal secretions occur everyday, but is very sensitive to stress (physical or psychological)  Cortisol ‘slips’ into cells and binds with receptor, then turns genes on or off Hormones are a large class of molecules that influence genetic express ...
47. Genetic Disorders
47. Genetic Disorders

... Sickle-Cell Anemia – red blood cells become half-moon, or sickleshaped; because of this unusual shape, the red blood cells cannot carry as much oxygen (leading to fatigue) and can block blood vessels (which can lead to lung and heart damage and stroke). Sickle-cell anemia is caused by a co-dominant ...
Additional file 3
Additional file 3

... plasmid DNA was isolated. The purified plasmid library was then transformed into electrocompetent BW25141 [14] by electroporation. Transformants were applied to LB agar plates containing 100 μg.mL-1 ampicillin and 2 mg.mL-1 arabinose. Glucuronidase substrate (40 μL of a 20 mg.mL-1 solution in DMSO) ...
Chapter 14 Study Workbook
Chapter 14 Study Workbook

... They used “shotgun sequencing,” which uses a computer to match DNA base sequences. To identify genes, they found promoters, exons, and other sites on the DNA molecule. To locate and identify as many haplotypes (collections of linked single-base differences) in the human population as possible, the I ...
Class Agenda Week of 8-13 Oct 2007
Class Agenda Week of 8-13 Oct 2007

... professor who led the research. But since Lincoln has no living direct descendants, confirming whether the nation's 16th president had the defective gene would require that his DNA be taken from historical artifacts and tested, an issue that has been debated over the years. The new findings on the a ...
BIOLOGY (Theory)
BIOLOGY (Theory)

... The familiar case of bears going into hibernation during winter is an example of escape in time. Some snails and fish go into aestivation to avoid summer–related problems (heat and desiccation). Under unfavourable conditions, many zooplankton species in lakes and ponds are known to enter diapause, a ...
12-1 DNA
12-1 DNA

... C. An operon includes a promoter, an operator, and one or more structural genes that code for all the proteins needed to do a job. –Operons are most common in prokaryotes. –The lac operon was one of the first examples of gene regulation to be discovered. –The lac operon has three genes that code fo ...
Biotechnology - Glen Rose FFA
Biotechnology - Glen Rose FFA

... classical plant and animal breeding ...
Biology
Biology

... 16. What is cell differentiation? Give an example of a differentiated cell. Genetics – Chapter 11 17. What is an allele? How is an allele different from a gene? 18. Compare and contrast genotype and phenotype. Give an example of a genotype and a phenotype. 19. Explain the difference between a homozy ...
Review Topics for Final Part 1
Review Topics for Final Part 1

... — DNA that was missing from double stranded break is replaced by polymerization  Holliday intermediates are cleaved in one of two ways. What is the difference between the two sets of products?  What is the purpose of RecA protein? What Rec factors promote and inhibit RecA assembly?  How can fork ...
ANSWERS - midterm study guide
ANSWERS - midterm study guide

... 12. What is a carrier? ______________________________________ Give an example of the genotype of a carrier.___ 13. What disease does someone have if they have Trisomy 21. ______________________________________________ What causes it? (Think about meiosis.) ___________________________________________ ...
DNA Analysis in China
DNA Analysis in China

... DNA Analysis in China by Hu Lan Genetics Laboratory, Institute of Forensic Sciences People’s Republic of China The Genetics Laboratory of the Institute of Forensic Sciences was the first DNA analysis unit established in China and is China’s central and main DNA profiling laboratory. The laboratory, ...
11.3_Other_Patterns_of_Inheritance
11.3_Other_Patterns_of_Inheritance

... Review What does incomplete dominance mean and give an example Design an Experiment Design an experiment to determine whether the pink flowers of petunia plants result from incomplete dominance Compare and Contrast What is the difference between incomplete dominance and codominance ...
Homework Assignment #1
Homework Assignment #1

... 3. (2 pts) RNA polymerase III internal promoters are more than 50 nucleotides downstream of the initiation site. How is RNA polymerase III positioned for correct initiation? Answer: The transcription factor TFIIIC and TFIIIA bind to these internal promoter elements and by themselves do not bind to R ...
word - The Department of Ecology and Evolutionary Biology at
word - The Department of Ecology and Evolutionary Biology at

... because in most multicellular organisms only a small percentage of the cells retain the ability to reproduce. This raises the question why cells would evolve to relinquish their potential for reproduction. It is now generally thought that multicellular life evolved from ancestral forms that were col ...
T. brucei
T. brucei

... for protein coding genes. L. Major - manual examination of predictions carried out at both SBRI and WTSI refined the number of likely protein-coding genes to 8021 for the version 3.0 release. Addition of new sequence in version 3.1, has brought the current total number in GeneDB (the “official” repo ...
Mendelian Inheritance Part 2 - Oklahoma City Community College
Mendelian Inheritance Part 2 - Oklahoma City Community College

... Four Gametes With Single Chromosomes ...
Transcriptome - Nematode bioinformatics. Analysis tools and data
Transcriptome - Nematode bioinformatics. Analysis tools and data

... immunoprecipitation with an antibody or by tagging the factor of interest with an isolatable epitope (e.g GST fusion). • Fractionate the DNA associated with the transcription factor, reverse the cross links, label and hybridize to an array of protomer ...
< 1 ... 958 959 960 961 962 963 964 965 966 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report