• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
FSHD Science 101. Alexandra Belayew, PhD
FSHD Science 101. Alexandra Belayew, PhD

... Every cell of an individual has the same genetic programm In the nucleus: 23 chromosome pairs ...
Full Text - Harvard University
Full Text - Harvard University

... that we call these regions ‘introns’ (for intragenic regions). Despite knowing the sequence of only a small number of genes in 1978, Gilbert was able to correctly predict that introns account for approximately ten times more genomic sequence than exons. But what was the function of this prevalent ge ...
insights
insights

... of these are shared with their immediate downstream progeny. Thus, establishing these Fdg5-reporter mouse lines and demonstrating the high and specific expression pattern that can be achieved with insertions into this locus is a significant contribution to the field. The power of the study lies in t ...
Microarray Analysis 2
Microarray Analysis 2

... Clustering and pattern detection ...
ppt
ppt

... We define the error for a set of genes S of size n as: ...
Nucleic Acids Research
Nucleic Acids Research

... strengthened with some recent genome-scale works for the species (7,8). Below the three major species, several species are clustered in Figure 2. Among them zebrafish, Danio rerio, is slightly ahead, indicating that the fish has recently been recognized as the most suitable model system for genetic ...
Inclusive Fitness
Inclusive Fitness

... Reproductive restraint Birds can produce many more eggs than they actually do! Wynne-Edwards beleied that selection also acted on the species level to stop massive overpopulation ...
File - Science with Mrs. Levin
File - Science with Mrs. Levin

... _________ is twisted ladder known as a “double helix” where the sides are made up of alternating sugar   and phosphate molecules. The rungs are made of nitrogen __________ and the order of three of these   bases codes for a specific amino acid.  The three­base code unit determines the order in which ...
answers
answers

... Which kind of RNA has an ANTICODON? __t-RNA____ What kind of molecules make up ribosomes? ___PROTEINS______ & ___r-RNA__________ Which cell part makes r-RNA? ___NUCLEOLUS__ Which cell part makes proteins? _RIBOSOMES______________ The ribosome makes sure the amino acid is put in the right spot by mat ...
`We are all virtually identical twins`
`We are all virtually identical twins`

... imagined. Probably 99 per cent of the discoveries in biology remain to be made. This is very different from what I was told in the 1970s, when I was working on my doctorate at the University of California, San Diego, which was that basically it was going to be very difficult to come up with any new ...
Slide 1
Slide 1

... researchers identified dozens of genes in embryonic stem cells that contributed to this pluripotency. Shinya Yamanaka demonstrated that just four genes out of identified before could induce pluripotency in already-differentiated skin cells(2006 on mouse cells, 2007 on human cells). Finally, Yamanaka ...
Computational methods for the analysis of bacterial gene regulation
Computational methods for the analysis of bacterial gene regulation

... datasets. Verified transcripts for E. coli and/or B. subtilis, in combination with statistical and machine learning methods, are used to determine the optimal thresholds and cutoffs for these criteria resulting in predictive models which can be applied to other organisms. At pr ...
Untitled
Untitled

... •Sperm cells can carry either an X or a Y chromosome. ...
Genetic Variation
Genetic Variation

... • Environmental factors are things in an organism's surroundings or lifestyle that can influence it in various ways. For example, body weight in humans may be influenced by genes, but is also influenced by diet. In this case, diet is an example of an environmental factor ...
Genetic basis and examples of potential unintended effects due to
Genetic basis and examples of potential unintended effects due to

... • Insertions/deletions every 126 bp, ranging in size from 1 bp ...
Gene converter - Bioinformatics Platform
Gene converter - Bioinformatics Platform

... SUMMARY CBS is a very helpful tool when characterizing the binding sites for certain TFs in a regulatory sequence. However, it is not uncommon that other applications deal with a different nomenclature for the genes involved in the study. Thus, it is interesting to use this CBS tool to convert gene ...
DNA: Structure and Function
DNA: Structure and Function

... Watson & Crick Model • DNA is composed of 2 chains of nucleotides that form a double helix shape • The two strands are antiparallel. • The backbone of the DNA molecule is composed of alternating phosphate groups and sugars • The complimentary bases form hydrogen bonds between the strands • A is c ...
Various forms of the same gene are called
Various forms of the same gene are called

... heterozygote, this is a case of _________________________________. When one locus has an effect on more than one character, even seemingly unrelated characters, this is called _________________________. When one character is affect by many multiple loci, this is called ____________________________. ...
New KS3 Year 9 Medium Plan
New KS3 Year 9 Medium Plan

... the characteristics of the organism Most students will be able to describe the process of fertilisation Some students will explain the process of fertilisation using appropriate terminology ...
Chapter 15
Chapter 15

... protein synthesis to occur. This is accomplished by activating enzymes called aminoacyl-tRNA synthetases. There is one enzyme for each of the 20 amino acids. • tRNA molecules are bifunctional; they need to interact with amino acids and mRNA molecules. • There is an acceptor stem, where amino acid bi ...
Genetic Tools
Genetic Tools

... • Genes that are carried on the X chromosome are called Sex-linked genes. • Traits determined by sex-linked genes are called sexlinked traits. • Because of this, sex-linked traits are most often seen in males who only have one copy of the X ...
Lecture#10 - Classification of mutations and gene function Readings
Lecture#10 - Classification of mutations and gene function Readings

... 1. DNA sequence can be altered and a mutant or variant can result. 2. Multi-cellular organism can have somatic and germline mutations. 3. From the wide variety of mutational possibilities for most genes (alleles), we can usually distinguish only functional and non-functional alleles. 4. The function ...
Bell Ringer
Bell Ringer

... • The amount of light an organism receives • The temperature in which the organism lives • Example: tree leaves that grow in full sunlight are thicker than those that grow in shadier conditions • Even though the genetic makeup is the same ...
Detailed History - Aggie Horticulture
Detailed History - Aggie Horticulture

... 1946 Max Delbruck and Alfred Day Hershey independently discovered that the genetic material from different viruses can be combined to form a new type of virus. This process was another example of genetic recombination. 1947 Barbara McClintock first reported on "transposable elements" - known today a ...
Notes on The Basics of Genetics Part 1
Notes on The Basics of Genetics Part 1

... 1. Traits are passed or inherited from one generation to the next. 2. Traits of an organism are controlled by genes. A gene is a section of a chromosome, that codes for a specific trait. 3. Organisms inherit genes in pairs, one from each parent. *Human sex cells (sperm or egg) contain 23 chromosomes ...
< 1 ... 907 908 909 910 911 912 913 914 915 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report