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Themes in Biology - College of Science and Mathematics
Themes in Biology - College of Science and Mathematics

... Yet it is still important to examine the consequences and the likelihood of this scenario. The media may dream up and forecast robotic cloned armies of Hitler; however, identical twins illustrate that being genetically identical does not remove their humanness. ...
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... MicroRNAs are an abundant class of 21–22 nt, non-coding RNAs that play a critical role in a wide range of developmental pathways in plants through ARGONAUTE1 (AGO1) post-transcriptional regulation of target mRNAs. Genetic analysis of ago1 mutants with informative defects has provided valuable insigh ...
Molecular Evidence for Evolution
Molecular Evidence for Evolution

... A chicken and a gorilla will have more differences between their DNA and amino acid sequences than a gorilla and an orangutan. That means the chicken and gorilla had a common ancestor a very long time ago, while the gorilla and orangutan shared a more recent common ancestor. This provides additional ...
Class VII Using cloned DNA fragments to study gene expression 1
Class VII Using cloned DNA fragments to study gene expression 1

... B. The “activity” of the same gene might be different in two different individuals (or tissues or organisms). This would cause differences in “gene expression”, and this in turn would cause differences in mRNA levels, which causes differences in protein quantities. Since proteins determine function, ...
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Name Date Period BioTechnology: Web Quest Part 1

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Osman et al Supplementary Materials 1. Supplementary Materials

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Chapter 7/8-Animal Biotechnology
Chapter 7/8-Animal Biotechnology

... And for reporter constructs, see http://bcs.whfreeman.com/lodish5e/pages/bcsmain.asp?v=category&s=00010&n=15000&i=15010.01&o=|00510|00610|00520|00530|00540|00560|00570|00590|00600|00 ...
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Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
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