
Proximal promoter
... the distal sequence upstream of the gene that may contain additional regulatory elements, often with a weaker influence than the proximal promoter – Anything further upstream (but not an enhancer or other regulatory region whose influence is positional/orientation independent) – Specific transcripti ...
... the distal sequence upstream of the gene that may contain additional regulatory elements, often with a weaker influence than the proximal promoter – Anything further upstream (but not an enhancer or other regulatory region whose influence is positional/orientation independent) – Specific transcripti ...
Inheritance – question hunt Teaching notes
... 10. Mendel discovered that characteristics are not blended, there are dominant forms and recessive forms of characteristics. 11. Cell division, chromosomes copied, line up in middle in pairs, crossing over may occur, one of each pair moves to opposite poles, cell divides. Chromosomes then line up in ...
... 10. Mendel discovered that characteristics are not blended, there are dominant forms and recessive forms of characteristics. 11. Cell division, chromosomes copied, line up in middle in pairs, crossing over may occur, one of each pair moves to opposite poles, cell divides. Chromosomes then line up in ...
Gene Regulation and Genetics
... In 1981, Dr. David Ledbetter and his colleagues reported a breakthrough discovery: They found that many people with PWS had the same segment of genes missing from one of their chromosomes. They had discovered the deletion on chromosome 15 that accounts for more than half of the cases of PWS. Since t ...
... In 1981, Dr. David Ledbetter and his colleagues reported a breakthrough discovery: They found that many people with PWS had the same segment of genes missing from one of their chromosomes. They had discovered the deletion on chromosome 15 that accounts for more than half of the cases of PWS. Since t ...
PowerPoint - USD Biology
... Differential gene expression between highand low-altitude populations • Mean minimum temperature at high-altitude site in Feb ~ 1 °C (~ 10 °C colder than low altitude site) • Genes up-regulated in high-altitude birds involved in – ATP production (ADP, ATP translocases and ATP synthases) – Citric ac ...
... Differential gene expression between highand low-altitude populations • Mean minimum temperature at high-altitude site in Feb ~ 1 °C (~ 10 °C colder than low altitude site) • Genes up-regulated in high-altitude birds involved in – ATP production (ADP, ATP translocases and ATP synthases) – Citric ac ...
Feng Zhang, Ph.D.
... Palindromic Repeats) have recently been harnessed as so-called genome editing tools. These tools allow researchers to home in on “typos” within the three-billion-letter sequence of the human genome, and cut out and even alter the problematic sequence. The Cas9 complex, which includes the CRISPR “cle ...
... Palindromic Repeats) have recently been harnessed as so-called genome editing tools. These tools allow researchers to home in on “typos” within the three-billion-letter sequence of the human genome, and cut out and even alter the problematic sequence. The Cas9 complex, which includes the CRISPR “cle ...
ABO Blood Types
... the time); Overall lower concentration of hemoglobin all the time (codominance = both normal and mutant alleles expressed) ...
... the time); Overall lower concentration of hemoglobin all the time (codominance = both normal and mutant alleles expressed) ...
M:\Biology 3201.June 2009.wpd
... The abuse of steroid hormones, such as testosterone, by athletes can lead to problems with homeostasis. Explain how this abuse can have a negative impact on the body. ...
... The abuse of steroid hormones, such as testosterone, by athletes can lead to problems with homeostasis. Explain how this abuse can have a negative impact on the body. ...
DNAandGeneticsEducDept
... couple who are planning to have a child but who suspect that there is a greater than normal risk of the child being affected by a genetic disorder ...
... couple who are planning to have a child but who suspect that there is a greater than normal risk of the child being affected by a genetic disorder ...
Supplementary Figure Legend and Reference
... of quantitative PCR from immunoprecipitation with NKX3.1 antibody over IgG control. Realtime PCR was done with primers shown in the table. C. LNCaP cells treated as shown were subjected to ChIP-reChIP assay with primers flanking ERG II,III and ERG IV break sites. Cell extracts went through two round ...
... of quantitative PCR from immunoprecipitation with NKX3.1 antibody over IgG control. Realtime PCR was done with primers shown in the table. C. LNCaP cells treated as shown were subjected to ChIP-reChIP assay with primers flanking ERG II,III and ERG IV break sites. Cell extracts went through two round ...
DNA, restriction enzymes
... “Celera Genomics today announced that it has completed the first assembly of the human genome, which has revealed a total of 3.12 billion base pairs in the human genome. ... Celera assembled the human genome using 26.4 million sequences of 550 base pairs long for a total of 14.5 billion base pairs s ...
... “Celera Genomics today announced that it has completed the first assembly of the human genome, which has revealed a total of 3.12 billion base pairs in the human genome. ... Celera assembled the human genome using 26.4 million sequences of 550 base pairs long for a total of 14.5 billion base pairs s ...
DNA Review
... Basic unit of all life Human composed of ~100 trillion cells Cell has organelles for different functions Nucleus contains the code of life deoxyribonucleic acid (DNA) Every cell except for red blood cells (don’t have nucleus) contain DNA • DNA – complete set of instructions for ...
... Basic unit of all life Human composed of ~100 trillion cells Cell has organelles for different functions Nucleus contains the code of life deoxyribonucleic acid (DNA) Every cell except for red blood cells (don’t have nucleus) contain DNA • DNA – complete set of instructions for ...
Pre-exam 2
... events of meiosis. Then, use Punnett squares to predict the probabilities of each of the possible genotypes and phenotypes of the offspring in each of the following crosses. [See the How to Solve a ...
... events of meiosis. Then, use Punnett squares to predict the probabilities of each of the possible genotypes and phenotypes of the offspring in each of the following crosses. [See the How to Solve a ...
Genetics and gene Therapy
... virus and the envelope of another. • Pseudotypes composed of the nucleocapsid of vesicular stomatitis virus (a rhabdovirus) and the envelope of human immunodeficiency virus(HIV,a retrovirus) are currently being used to study the immune response to ...
... virus and the envelope of another. • Pseudotypes composed of the nucleocapsid of vesicular stomatitis virus (a rhabdovirus) and the envelope of human immunodeficiency virus(HIV,a retrovirus) are currently being used to study the immune response to ...
Using hair color to make a clear connection between genotype and
... color? There are many shades of brown hair, from light brown (blonde) to medium brown to dark brown to a brown that is so dark it looks black (Figure 1). Why is this? People aren’t peas or fruit flies, so students can’t just “set up the crosses”—mix the parents together and collect the F1s and event ...
... color? There are many shades of brown hair, from light brown (blonde) to medium brown to dark brown to a brown that is so dark it looks black (Figure 1). Why is this? People aren’t peas or fruit flies, so students can’t just “set up the crosses”—mix the parents together and collect the F1s and event ...
Questions
... 1. What two ideas did Lamarck use to describe evolution? 2. What evidence do scientists have to show that evolution has occurred? 3. What are the main points of Darwin’s theory of evolution? 4. Name and describe 3 types of natural selection. 5. Describe the process of speciation. 6. According to the ...
... 1. What two ideas did Lamarck use to describe evolution? 2. What evidence do scientists have to show that evolution has occurred? 3. What are the main points of Darwin’s theory of evolution? 4. Name and describe 3 types of natural selection. 5. Describe the process of speciation. 6. According to the ...
Molecular Koch`s Postulates Applied to Microbial Pathogenicity
... course, for some pathogens, such study is not yet functional analysis, and even sequencing it are not possible. Moreover, for either alternative, it is essensufficient unless one can rigorously prove that the tial that the test of pathogenicity be performed with loss (or gain) of the gene in the spe ...
... course, for some pathogens, such study is not yet functional analysis, and even sequencing it are not possible. Moreover, for either alternative, it is essensufficient unless one can rigorously prove that the tial that the test of pathogenicity be performed with loss (or gain) of the gene in the spe ...
Ab initio gene prediction
... Markov chain - a linear series of states in which each state is dependent only on the previous state. HMM - a model that uses a Markov chain to infer the most likely states in data with unknown states ("hidden" states). A Markov chain has states and transition probabilities: ...
... Markov chain - a linear series of states in which each state is dependent only on the previous state. HMM - a model that uses a Markov chain to infer the most likely states in data with unknown states ("hidden" states). A Markov chain has states and transition probabilities: ...
3.1 Genes - Peoria Public Schools
... https://www.dnalc.org/view/15477-The-publicHuman-Genome-Project-mapping-the-genomesequencing-and-reassembly-3D-animation-.html ...
... https://www.dnalc.org/view/15477-The-publicHuman-Genome-Project-mapping-the-genomesequencing-and-reassembly-3D-animation-.html ...
03-Heredity & Environment
... DNA (deoxyribonucleic acid) The basis of heredity Chromosome Molecule of DNA Make up chromosomes Humans = 46 (23 pairs) of chromosomes Genes = Section of chromosomes Allele = Slight normal variation in a gene ...
... DNA (deoxyribonucleic acid) The basis of heredity Chromosome Molecule of DNA Make up chromosomes Humans = 46 (23 pairs) of chromosomes Genes = Section of chromosomes Allele = Slight normal variation in a gene ...
Section 2 Gene Expression in Development and Cell Division
... – The homeoboxes of many eukaryotic organisms appear to be very similar. ...
... – The homeoboxes of many eukaryotic organisms appear to be very similar. ...
Site-specific recombinase technology

Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse