• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
bioinformatics - Campus
bioinformatics - Campus

... the genetic material belonging to different species. From the double helix to the genome > Recombinant DNA ...
Intro To Evolutionary Process
Intro To Evolutionary Process

... – less likely to have some individuals that can adapt – harmful alleles can become more common due to chance rather than the ability of the survivor. ...
An Aside: X Inactivation in Female Mammals
An Aside: X Inactivation in Female Mammals

... In females, one X chromosome is inactivated (at random) and condenses into a compact Barr body along the inside of the nuclear envelope. Most genes on this X chromosome are not expressed. ...
The Genetics of C elegans (Brenner)
The Genetics of C elegans (Brenner)

... define the unitary steps of development in terms of genetic analysis … “ 1963 Research Proposal: “The New Major problem in molecular biology is the genetics … of control mechanisms” ...
Ji et al J Theor Biol 2010
Ji et al J Theor Biol 2010

... to recognize poly(A) sites would not only prove useful for genome annotation in finding genes ends, but also for predicting alternative poly(A) sites. Features that define the poly(A) sites can now be extracted from poly(A) site datasets to build such predictive models. Using methods, including K-gr ...
Gene Section CBFb (subunit b of core binding factor)
Gene Section CBFb (subunit b of core binding factor)

Biology Final Exam
Biology Final Exam

... 4. During DNA replication, complementary strands of DNA are made from the original DNA strands. Using this template (original strand of DNA) and the base-pairing rules, give the complementary strand: TACCCCGAGAGG 5. What would be the complementary sequence of nucleotides for an mRNA molecule on the ...
Using restriction enzymes, foreign genes can be added to an
Using restriction enzymes, foreign genes can be added to an

... such as human growth hormone, by inserting that gene into bacteria. In order to combine the DNA, a chemical called a restriction enzyme is used to cut the DNA into fragments, exposing the gene of interest. On either side of the gene is an area of DNA called the “sticky end.” The bases of the sticky ...
Chapter 34 Study Guide File
Chapter 34 Study Guide File

... 23. Provide the basic causes and characteristics of the following disorders? cystic fibrosis: phenylketonuria: Tay-Sachs disease: osteogenesis imperfecta: multiple neurofibromatosis: Down syndrome: Klinefelter syndrome: Turner syndrome: 24. What are oncogenes? ...
Attenuated Infectious Hematopoietic Necrosis Virus (IHNV)
Attenuated Infectious Hematopoietic Necrosis Virus (IHNV)

... Novirhabdovirus has been engineered to modify the gene order and to evaluate the impact on a possible attenuation of the virus in vitro and in vivo. By reverse genetics, eight recombinant IHNV (rIHNV), termed NxGy according to the respective position of the nucleoprotein (N) and glycoprotein (G) gen ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

Jeffreys - OldForensics 2012-2013
Jeffreys - OldForensics 2012-2013

... first developed DNA fingerprinting techniques those of which are commonly used today for police and detective work, paternity tests, and immigration issues ...
Genetic Disorders in Culture and Art
Genetic Disorders in Culture and Art

... • New technologies permit the identification of and determination of function of all 25,000 human genes (Human Genome Project) • Genes associated with hundreds of genetic diseases have been cloned and used to develop genetics tests and new treatments • In vitro fertilization and genetic testing help ...
Citrus Breeding - Aggie Horticulture
Citrus Breeding - Aggie Horticulture

... Protoplast Fusion • Isolate cell protoplasts from callus or leaf tissue and fuse in vitro to form hybrids • Mostly polyploid plants regenerated from tissue culture- genetic hybrids • Overcome barriers to sexual reproduction ...
Chapter 12 “DNA, RNA, and Protein Synthesis” Reading/Study Guide
Chapter 12 “DNA, RNA, and Protein Synthesis” Reading/Study Guide

... 22. What is the purpose of RNA polymerase? ...
A Perspective on Human Genetics
A Perspective on Human Genetics

... • New technologies permit the identification of and determination of function of all 25,000 human genes (Human Genome Project) • Genes associated with hundreds of genetic diseases have been cloned and used to develop genetics tests and new treatments • In vitro fertilization and genetic testing help ...
KS3 Science
KS3 Science

... 4 James Watson, Francis Crick, Rosalind Franklin and Maurice Wilkins all helped to discover the structure of DNA. a Fill in the names below, to show what the scientists did. Just write in their last names. b Number the boxes to show the order in which these events occurred. ...
Putting genes into pathways
Putting genes into pathways

overview
overview

... Figure 2 Visualization of combined, large-scale interaction data sets in yeast. A total of 14,000 physical interactions obtained from the GRID database were represented with the Osprey network visualization system (see http://biodata.mshri.on.ca/grid). Each edge in the graph represents an interactio ...
CHAPTER 1
CHAPTER 1

... By the Numbers • The human genome contains 3164.7 million nucleotide bases (A, C, T, and G). • The average gene consists of 3000 bases, but sizes vary greatly, with the largest known human gene being dystrophin (2.4 million bases). • The total number of genes is estimated at 30,000 to 35,000, much ...
Unit 3 Genetics and Heredity Study Guide
Unit 3 Genetics and Heredity Study Guide

...  Mendel “crossed” pea plants by ______________________________________________________________  Mendel crossed pea plants with opposite traits (ex. Tall & short) ...
MEIS1 functions as a neuroblastoma oncogene
MEIS1 functions as a neuroblastoma oncogene

... most neuroblastoma cell lines investigated, as well as in many tumours. We decided to study the role of the MEIS genes in neuroblastoma pathogenesis. METHODOLOGY: MEIS1 expression in neuroblastoma cell lines was manipulated by transfection with the MEIS1E dominant-negative splice variant. High MEIS1 ...
Functional Genomics
Functional Genomics

... mapping, sequencing, and analyzing genomes  genome-level understanding of the molecular basis of the structure and functions  using whole-genome sequence information and highthroughput genomic technologies ...
Bild 1
Bild 1

... Supplemental Digital Content 1 - Figure 1. Global Gene Expression Analysis of Similarities in Biopsies. A data set consisting of ten biopsies from one patient projected by correspondence analysis to reveal similarities in global gene expression levels between different samples. Genes and samples tha ...
CA Breast cancer
CA Breast cancer

... The function of these genes was not clear until studies on a related protein in yeast revealed their normal role: they participate in repairing radiation-induced breaks in double-stranded DNA. This means that mutations might disable this mechanism leading to more errors in DNA replication. ...
< 1 ... 1193 1194 1195 1196 1197 1198 1199 1200 1201 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report