• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
4.16.08 105 lecture
4.16.08 105 lecture

... You inherited one copy of each of your genes from your mom and one from your dad. The genes from your mom and dad are similar but not identical. For example, you inherited two copies of the LDL receptor gene. They may be identical but there is a very good chance that some of the nucleotide letters a ...
Book 1.indb
Book 1.indb

... include various kinds of repeated sequences, mobile elements, amplicons, inserted viral and foreign DNA, B-chromosomes, plasmids and cytobionts. The abundance and intracellular topography of FGEs are different in different cells, tissues and individuals. Changes in the structure or order of OGEs cor ...
Analyzing Genomic Dose-Response Information to Inform Key
Analyzing Genomic Dose-Response Information to Inform Key

Write True if the statement is true
Write True if the statement is true

... 1. DNA contains the sugar ribose. 2. Messenger RNA carries copies of the instructions for making proteins from DNA to other parts of the cell. 3. RNA polymerase transfers amino acids to ribosomes. 4. The process of transcription produces a complementary strand of RNA on a DNA template. 5. The enzyme ...
E. coli plasmids
E. coli plasmids

... • The clustering of the restriction sites – Allows a DNA fragment with two different sticky ends – Other pUC vectors carry different combinations of restriction sites ...
Cell Reproduction and Genetics Answers
Cell Reproduction and Genetics Answers

... In the table provided, check all of the parts of the cell cycle that apply to the description in the left column. In mitosis, meiosis I, and meiosis II columns – state whether it happens in prophase (P), metaphase (M), anaphase (A), or telophase (T) Description / Event Interphase Mitosis Meiosis I M ...
+ Salmonella
+ Salmonella

... genome sequences? The majority of sequencing projects have been directed towards determining the full genome sequences of bacterial pathogens, with the goal of identifying and understanding the genetic basis of pathogenicity and virulence. ...
Sea squirt
Sea squirt

... Cells floating free in the body, such as red blood cells, are called corpuscles. These red blood cells have no nucleus, and are no longer able to renew themselves by dividing in two. To maintain its supply of fresh red blood cells, the human body makes use of stem cells whose job is to produce new r ...
Reporting Status or Progress - Tourette Syndrome Association
Reporting Status or Progress - Tourette Syndrome Association

... – Works like case-control studies, but parents act as controls ...
Finally…Genetically Modified Food
Finally…Genetically Modified Food

... • Precision – involve only individual genes that are desirable • Genes can act on only a specific part of plant or a particular portion of its life cycle • Safety of protein produced by gene can be studied prior to use in GM program • Improved crop yields • Improved crop characteristics • Reduce pes ...
ANSWERS Pitts` Biology 110 review: genetics 1
ANSWERS Pitts` Biology 110 review: genetics 1

... 27. At least one gene influences each trait; therefore, at least 75,000 genes would be present. However, some traits, such as height, are influenced by several sets of genes so the total could be well over 75,000. 28. The goal of the workers in the Human Genome Project is to prepare a “map” of each ...
The HNF-3 Gene Family of Transcription Factors in Mice: Gene
The HNF-3 Gene Family of Transcription Factors in Mice: Gene

... at least in part, from embryo nie endoderm. This fact, eombined with the high degree of similarity to the Drosophila gene forkhead, has led to the proposal that the HNF -3 genes are important in early endoderm and liver development in addition to their role in adult liver transcription (Lai and Darn ...
ncbi_locuslink_direc..
ncbi_locuslink_direc..

... NCBI Website – Understanding the information on the Locus Link page. This page provides all the information known about the gene you researched. This will include what is known about function, phenotypes, protein domains, and homologous genes for the gene you are researching. The amount of informati ...
mendelian genetics vocabulary
mendelian genetics vocabulary

... 19. Interbreeding: reproduction between genetically different individuals. 20. Locus (pl.loci): the specific location of a gene on a chromosome. 21. Parental generation: the first set of parents crossed to produce a filial generation. 22. Pedigree: a “family tree”. A chart of an individual's ancesto ...
DNA,RNA & Protein synthesis game
DNA,RNA & Protein synthesis game

... the debate regarding hereditary material over these two molecules ...
DNA Recombination Mechanisms
DNA Recombination Mechanisms

... Recombination provides a means by which a genome can change to generate new combinations of genes Homologous recombination allows for the exchange of blocks of genes between homologous chromosomes and thereby is a mechanism for generating genetic diversity Recombination occurs randomly between two h ...
Post-transcriptional Gene Silencing (PTGS)
Post-transcriptional Gene Silencing (PTGS)

... • Theory: by introducing an antisense gene (or asRNA) into cells, the asRNA would “zip up” the complementary mRNA into a dsRNA that would not be translated • The “antisense effect” was highly variable, and in light of the discovery of RNAi, asRNA probably inhibited its target by inducing RNAi rather ...
Document
Document

... Genes can be regulated at a number of points along the pathway: - Alteration of gene structure (DNA methylation/ changes in chromatin) - Transcription - mRNA processing - RNA stability (rate mRNA is degraded) - Translation - Posttranslational modification ...
Competency Goal 2: The learner will develop an understanding of
Competency Goal 2: The learner will develop an understanding of

glypican-6 (X-24): sc-130770
glypican-6 (X-24): sc-130770

... sulfate proteoglycans that are involved in the control of cell growth and division. Glypican-6, also known as GPC6, is a 555 amino acid protein that exists as both a lipid-anchored cell membrane peptide, as well as a secreted protein that is released into the extracellular space. Expressed ubiquitou ...
Ch 23 Evolution of Populations Guided Rdg
Ch 23 Evolution of Populations Guided Rdg

... 19. In the human eye, the retina is behind the nerves that form the optic nerve. Where the optic nerve leaves the eye, there is a hole, which results in a blind spot. It would be far better for the human eye to not have such a blind spot. How can it be that natural selection, the process that leads ...
DNA
DNA

... the order of the bases in one strand determines the order of the bases in the other ...
a π i, π i+1
a π i, π i+1

... • Perl has a set of wildcard characters for Reg. Exps. that are completely different than the ones used by Unix • the dot (.) matches any character • \d matches any digit (a number from 0-9) • \w matches any text character (a letter or number, not punctuation or space) • \s matches white space (any ...
4. Course administrator
4. Course administrator

... Fundamentals of genes, gene expression and regulation, and proteins What are biological databases? 1st Midterm EXAM Genome sequencing Protein bioinformatics Phylogeny/phylogenetics Gene expression analysis and microarray 2nd Midterm EXAM Practical bioinformatics-case examples Human genome project Hu ...
A 1
A 1

... Founders are individuals whose parents are not in the pedigree. They may of may not be typed (namely, their genotype measured). Either way, we need to assign probabilities to their actual or possible genotypes. This is usually done by assuming Hardy-Weinberg equilibrium (H-W). If the frequency of D ...
< 1 ... 1012 1013 1014 1015 1016 1017 1018 1019 1020 ... 1288 >

Site-specific recombinase technology



Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report