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Eltor (pseudoephedrine hydrochloride)
Eltor (pseudoephedrine hydrochloride)

... pseudoephedrine) through measurements of nasal airway resistance. Statistical analysis of nasal airway resistance values accumulated for each treatment group showed both a single dose of ELTOR 120 and repeated doses of immediate-release pseudoephedrine 60 mg produced a highly significant decongestan ...
Product Monograph - Paladin Labs Inc.
Product Monograph - Paladin Labs Inc.

... Patients should be cautioned not to consume alcohol while taking NUCYNTA® IR as it may increase the chance of experiencing serious adverse events, including death. Hyperalgesia that will not respond to a further dose increase of opioids can occur at particularly high doses. A tapentadol dose reducti ...
DHEA and Androgen Supplementation
DHEA and Androgen Supplementation

... effects generally disappear when DHEA is discontinued. Other possible side effects are menstrual irregularities, irritability and restlessness. There have been some reports where people who take large doses of DHEA (higher than proposed for your own treatment) can have irregular heartbeats or palpit ...
First Dose in Humans
First Dose in Humans

... Revision of Guidelines: Draft ICH M3(R2) ...
Omalizumab in ABPA - Stanford University
Omalizumab in ABPA - Stanford University

... Hilliard, JCF 2005;4:215-20 Interpatient variability to 100-fold (vs ~15-fold for itra) Pediatric doses 4 mg/kg vs 3 mg/kg in adults Usual maintenance dose 200 mg bid Suspension preferred to tablet TDM: target plasma steady-state trough 1-5.5 µg/mL Pasqualotto, Arch Dis Child 2008;93:578-81 ...
NEFAZODONE
NEFAZODONE

... at night • Anecdotal reports suggest that nefazodone may be effective in treating PMDD ✽ Studies suggest that cognitive-behavioral psychotherapy enhances the efficacy of nefazodone in chronic depression ✽ Risk of hepatotoxicity makes this agent a second-line choice and has led to its withdrawal from ...
Tenex - The Main Line Center for the Family
Tenex - The Main Line Center for the Family

... (sites on the surface of nerve cells where neurotransmitters bind) of adrenergic neurons. Tenex is an adrenergic agonist because of its action on norepinephrine neurotransmission, which may explain its role in the treatment of ADHD. ...
Antimicrobial Use in Mare Reproduction Kristina Lu VMD, DACT
Antimicrobial Use in Mare Reproduction Kristina Lu VMD, DACT

... In mares administered ceftiofur sodium (2 mg/kg IM BID), ceftiofur sodium was not detected in endometrial tissue after the fifth dose when steady state concentrations were achieved. In mares administered ceftiofur hydrochloride (2.2 mg/kg IM), a ceftiofur derivative was detected in endometrial tissu ...
Anticoagulation Guidelines for Reversal
Anticoagulation Guidelines for Reversal

...  Other: Consider activated charcoal if acute (<2 hours) overdose. Apixaban is not dialyzable. Fresh frozen plasma or packed red blood cells may be considered when supportive measures and control of site bleeding have failed. Prothrombin complex concentrate (PCC) has been shown in limited settings t ...
Adverse Reaction
Adverse Reaction

... extravasated; inject SC if needle is removed ...
taking care
taking care

... visit our dedicated support section on IBRANCE.com. Keep your friends close. Caregiving can be a consuming job. Your friends can provide a welcome distraction and offer help if you need it. Just as you’re supporting someone, it’s important not to abandon your own support system. ...
the file - General Practice
the file - General Practice

... 6. Clients who have long term opiate problems and have failed to stabilise on methadone. 7. Clients who have previously been prescribed methadone but did not respond successfully to their treatment plan. 8. Clients over 18 years. Do not use Buprenorphine for clients who:1. Are pregnant or breastfeed ...
Cefoperazone and Sulbactum
Cefoperazone and Sulbactum

... 114 mcg/ml. The mean serum concentration obtained at 15 min. after 500 mg and 1000 mg IV Sulbactam are 21-40 mcg/ml and 48-88 mcg/ml respectively. The average peak plasma concentration at 5 minutes after intravenous dose of 1g is 81mg/litre. Distribution: The protein binding of Cefoperazone is 82-93 ...
trelstar depot 3.75 mg
trelstar depot 3.75 mg

... women who are or may become pregnant while receiving the drug. Studies in pregnant rats administered triptorelin at doses of 2, 10, and 100 µg/kg/day (approximately equivalent to 0.2, 0.8, and 8 times the recommended human therapeutic dose based on body surface area) during the period of organogenes ...
Cardiovascular Pharmacology
Cardiovascular Pharmacology

... this may increase the interval during which ventricular premature depolarisations may induce reentry excitation through the specialised conducting system in atrial fibrillation, the principal action of digitalis in reducing the ventricular rate is its action on the AV node, leading to concealed cond ...
Dabigatran - Cardiology Update FK UNAND
Dabigatran - Cardiology Update FK UNAND

... AF confers an increased risk of stroke, which is dependant upon the presence of various stroke risk factors  All NVAF patient with ≥ 1 risk of stroke should receive anticoagulation - ASA is not an alternative, availability of NOACs has led to revisions in treatment guidelines  The net clinical be ...
Mefenamic Acid Capsules USP Rx Only Cardiovascular Risk
Mefenamic Acid Capsules USP Rx Only Cardiovascular Risk

... age. A study in 17 preterm infants administered 2 mg/kg indicated that the half-life was about five times as long as adults, consistent with the low activity of metabolic enzymes in newborn infants. The mean Cmax in this study was 4 mcg/mL (range 2.9 to 6.1). The mean time to maximum concentration ( ...
PLAN B PRODUCT MONOGRAPH
PLAN B PRODUCT MONOGRAPH

... Hepatic Following a single oral dose of 0.75 mg, levonorgestrel does not appear to be significantly metabolized by the liver. The risks of Plan B® to women with a history of liver disease are unknown. Women with a history of liver disease should be given Plan B® under medical supervision especially ...
Title here
Title here

... • Letrozole – no androgenic, oestrogenic or progestogenic activity observed • Exemestane – androgenic side effects reported at clinical doses in patients with ABC – including acne, hirsutism and weight gain – due to the fact that it is a steroidal molecule, designed to mimic androgens and to bind in ...
1 PRODUCT INFORMATION FLIXOTIDE NEBULES NAME OF THE
1 PRODUCT INFORMATION FLIXOTIDE NEBULES NAME OF THE

... 150 µg/kg/day and above. In an inhalational teratology study in rats, fluticasone propionate was not teratogenic at inhalational doses up to 68.7 µg/kg/day, but reduced fetal bodyweight and delayed fetal development were noted at maternal doses of 25.7 µg/kg/day and greater. As for previous compound ...
Marie-Chantal Bonhomme1, Nadia Cardillo Marricco1
Marie-Chantal Bonhomme1, Nadia Cardillo Marricco1

... Ramipril is a potent, long-acting, angiotensin-converting enzyme (ACE) inhibitor and its effect on hypertension appears to result at least in part from inhibition of both tissue and circulating ACE activity, thereby reducing angiotensin-II formation in tissue and plasma. Ramipril tablet is indicated ...
Determination of an Optimal Dosing Regimen for Fexinidazole, a
Determination of an Optimal Dosing Regimen for Fexinidazole, a

... Study protocol 3 was carried out following a population pharmacokinetic evaluation using all available data from the preceding studies exploring the various dosing regimens with food. The aim was to ascertain the most efficient dosing schedule in terms of rapidity to peak steady state and extended d ...
Opioid conversion tips Changing to another oral opioid
Opioid conversion tips Changing to another oral opioid

... When is it addiction? How can you tell if your patient is truly addicted to opioids? The following definitions are jointly from The American Academy of Pain Medicine, the American Pain Society, and the American Society of Addiction Medicine: Addiction: Addiction is a primary, chronic, neurobiologic ...
Pharmacologic Control of Vomiting
Pharmacologic Control of Vomiting

... The most effective antiemetics are those that act at both the vomiting center and the chemoreceptor trigger zone. Vomiting is a protective reflex and when it occurs only occasionally treatment is not generally required. However, patients that continue to vomit should be given antiemetics to help red ...


... • Terbinafine 250mg once daily x 12 weeks was initiated • Mr T. returned 3 months later after completing a course of treatment and noticed an improvement in his toe appearance. However, it still did not look “normal”. He was reassured that he did not require additional treatment at this time. The na ...
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Dydrogesterone



Dydrogesterone (INN, USAN, BAN), is also chemically known as 9β,10α-pregna-4,6-diene-3,20-dione. Dydrogesterone (6-dehydro-retroprogesterone) is a hormonally active, non-androgenic steroid that was developed in the 1950s.Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy.Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency: Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.
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