Note for Guidance on the Quality, Preclinical and Clinical
... in a temporal or tissue-specific manner, summary evidence should be provided to demonstrate such specificity from a product characterisation and control viewpoint. Cross-reference should be made to the detailed reports included in the relevant parts of clinical and preclinical dossiers. Selection ma ...
... in a temporal or tissue-specific manner, summary evidence should be provided to demonstrate such specificity from a product characterisation and control viewpoint. Cross-reference should be made to the detailed reports included in the relevant parts of clinical and preclinical dossiers. Selection ma ...
HED - National Foundation for Ectodermal Dysplasias
... have two copies of every DNA molecule, one from our mother and one from our father. Despite the importance of DNA (it makes us what we are), it is delicate and may change as it passes from one generation to the next. Many of the changes in DNA, called mutations, are harmful; that is, they may lead ...
... have two copies of every DNA molecule, one from our mother and one from our father. Despite the importance of DNA (it makes us what we are), it is delicate and may change as it passes from one generation to the next. Many of the changes in DNA, called mutations, are harmful; that is, they may lead ...
Title A Fluorescently Labeled, Hyperbranched Polymer
... In conclusion, we have demonstrated successful synthesis of hyperbranched polymer using the DE-ATRP method. This hyperbranched pD-co-E polymer has shown exceptional physical properties demonstrated by its capability to form condensing particles that can quench the fluorescence of rhodamine molecules ...
... In conclusion, we have demonstrated successful synthesis of hyperbranched polymer using the DE-ATRP method. This hyperbranched pD-co-E polymer has shown exceptional physical properties demonstrated by its capability to form condensing particles that can quench the fluorescence of rhodamine molecules ...
Y-DNA and Documentary Research Collaboration Reveals
... documentation also showed them to be probable descendants of the Rabbi Weil der Stadt. They also matched the WIRTH group. A fourth match, also recruited by the Frankfurt project, represented a Weil branch whose surname became Rindskopf in the 17th century. When these new matches were incorporated in ...
... documentation also showed them to be probable descendants of the Rabbi Weil der Stadt. They also matched the WIRTH group. A fourth match, also recruited by the Frankfurt project, represented a Weil branch whose surname became Rindskopf in the 17th century. When these new matches were incorporated in ...
Load-balanced CDS construction in wireless sensor networks via
... optimisation to identify Steiner nodes as the connectors in the CDS construction. The approximation factor on the size of a CDS is improved to 8opt, while this distributed algorithm has O(n) message complexity, and O ( Δn) time complexity. Later, Li et al. (2005) reported a better approximation fact ...
... optimisation to identify Steiner nodes as the connectors in the CDS construction. The approximation factor on the size of a CDS is improved to 8opt, while this distributed algorithm has O(n) message complexity, and O ( Δn) time complexity. Later, Li et al. (2005) reported a better approximation fact ...
Genetic diversity and epidemiology of infectious hematopoietic
... 6 or 7 d post-inoculation. Infected cells and media for each virus isolate were centrifuged and 1.0 m1 aliquots of supernatant were frozen at -7O0C. These served as the virus stock used in the study. The reference virus strain, RB1, isolated in 1975 from steelhead Oncorhynchus mykiss at the Round Bu ...
... 6 or 7 d post-inoculation. Infected cells and media for each virus isolate were centrifuged and 1.0 m1 aliquots of supernatant were frozen at -7O0C. These served as the virus stock used in the study. The reference virus strain, RB1, isolated in 1975 from steelhead Oncorhynchus mykiss at the Round Bu ...
BRCA1 and BRCA2 Mutations
... A positive test result means that you have the BRCA mutation for which you have been tested. A negative test result can mean several things, depending on the testing that you have had performed: • If you were tested for a specific BRCA mutation linked to cancer in your family (eg, a family member w ...
... A positive test result means that you have the BRCA mutation for which you have been tested. A negative test result can mean several things, depending on the testing that you have had performed: • If you were tested for a specific BRCA mutation linked to cancer in your family (eg, a family member w ...
Two enhancer regions in the mouse En-2 locus
... Founder embryos were analyzed between 10.5 to 12.5 days of gestation (Table 1) whereas embryos from each of the five transgenic lines that express the large En-2/lacZ construct (see results) were analyzed at 8.5, 9.5, 10.5, 11.5 and 12.5 days of gestation. One line (Tg5) was also analyzed at 15.5 da ...
... Founder embryos were analyzed between 10.5 to 12.5 days of gestation (Table 1) whereas embryos from each of the five transgenic lines that express the large En-2/lacZ construct (see results) were analyzed at 8.5, 9.5, 10.5, 11.5 and 12.5 days of gestation. One line (Tg5) was also analyzed at 15.5 da ...
MOLECULAR RECOGNITION AND RESPONSE IN POLLEN AND
... of two fungal RNases, RNase T2 and RNase Rh. It is this similarity that led to the discovery that S-proteins are RNases (McClure et al 1989). The finding that RNases are employed by the pistil to reject self pollen raised the possibility that the RNase activity is responsible for growth inhibition o ...
... of two fungal RNases, RNase T2 and RNase Rh. It is this similarity that led to the discovery that S-proteins are RNases (McClure et al 1989). The finding that RNases are employed by the pistil to reject self pollen raised the possibility that the RNase activity is responsible for growth inhibition o ...
The role of meiotic drive in hybrid male sterility
... transmission advantage can allow the driving chromosome to spread within a species. Driving alleles also tend to be located in inversions or other regions of low recombination, and therefore deleterious mutations linked to the driver may increase in frequency via hitchhiking. Drivers located on the ...
... transmission advantage can allow the driving chromosome to spread within a species. Driving alleles also tend to be located in inversions or other regions of low recombination, and therefore deleterious mutations linked to the driver may increase in frequency via hitchhiking. Drivers located on the ...
Results Key - Neogen Genomics
... A Genomic Predicted Transmitting Ability (PTA) is a measure of the genetic merit of an animal in a breeding program, and in particular, how the animal and its progeny are likely to perform. It is always reported as the deviation from a pre-determined base (the base is updated every 5 years) and is a ...
... A Genomic Predicted Transmitting Ability (PTA) is a measure of the genetic merit of an animal in a breeding program, and in particular, how the animal and its progeny are likely to perform. It is always reported as the deviation from a pre-determined base (the base is updated every 5 years) and is a ...
NeuroGeM, a knowledgebase of genetic modifiers
... SCA1, SCA3, SCA7, PolyQ) share a number of genetic modifiers and non-modifiers while they share far fewer modifiers and non-modifiers with AD. Indeed a strong anti-correlation is observed when comparing the modifiers and non-modifiers of ADAβ and SCA3. In order to gain further insight into this “ant ...
... SCA1, SCA3, SCA7, PolyQ) share a number of genetic modifiers and non-modifiers while they share far fewer modifiers and non-modifiers with AD. Indeed a strong anti-correlation is observed when comparing the modifiers and non-modifiers of ADAβ and SCA3. In order to gain further insight into this “ant ...
Genome-Wide Scan of Obesity in the Old Order Amish*
... Segregation analyses suggest that single genes with relatively large effects as well as polygenes with smaller effects contribute to the development of obesity. Studies in several populations suggest that major genes inherited in a recessive manner may account for 35– 45% of the variation in obesity ...
... Segregation analyses suggest that single genes with relatively large effects as well as polygenes with smaller effects contribute to the development of obesity. Studies in several populations suggest that major genes inherited in a recessive manner may account for 35– 45% of the variation in obesity ...
ALK
... Small-molecule tyrosine kinase inhibitors -standard therapies for several types of cancer( chronic myeloid leukemia, epidermal growth factor receptor (EGFR)–mutated non–small-cell lung cancer (NSCLC), and ALKrearranged NSCLC ) crizotinib - In NSCLC, ALK rearrangement, the first ALK inhibitor tested ...
... Small-molecule tyrosine kinase inhibitors -standard therapies for several types of cancer( chronic myeloid leukemia, epidermal growth factor receptor (EGFR)–mutated non–small-cell lung cancer (NSCLC), and ALKrearranged NSCLC ) crizotinib - In NSCLC, ALK rearrangement, the first ALK inhibitor tested ...
A Maize Glutaredoxin Gene, Abphyl2, Regulates
... maxima in Abph2 mutant meristems, compared with one maximum in the wild type (Figures 1E and 1F). Abph2 mutants also had dramatically enlarged SAMs; for example, in embryos 26 d after pollination (DAP), meristem width in Abph2 (185 6 5 mm, n = 10) was nearly 2-fold that of the wild type (96 6 12 mm, ...
... maxima in Abph2 mutant meristems, compared with one maximum in the wild type (Figures 1E and 1F). Abph2 mutants also had dramatically enlarged SAMs; for example, in embryos 26 d after pollination (DAP), meristem width in Abph2 (185 6 5 mm, n = 10) was nearly 2-fold that of the wild type (96 6 12 mm, ...
Synergistic interaction of variants in CHEK2 and BRCA2 on breast
... that these observations get extended to other populations where these or other founder mutations are present. To our knowledge, BRCA2 T1915M is at present the only low-penetrance missense variant reported for BRCA2 that seems to be associated with a significant risk modification. As a caveat, our fi ...
... that these observations get extended to other populations where these or other founder mutations are present. To our knowledge, BRCA2 T1915M is at present the only low-penetrance missense variant reported for BRCA2 that seems to be associated with a significant risk modification. As a caveat, our fi ...
Multiple affected Afrikaner families in a schizophrenia genetic study
... Schizophrenia has a heritability in the 60% to 90% range.1 The search for chromosomal loci and genes has been slow and frustrating. The reason for this may be because there is multiple susceptibility genes involved, each of small effect. In many cases the development of the disorder may depend on th ...
... Schizophrenia has a heritability in the 60% to 90% range.1 The search for chromosomal loci and genes has been slow and frustrating. The reason for this may be because there is multiple susceptibility genes involved, each of small effect. In many cases the development of the disorder may depend on th ...
Exceptionally high levels of recombination
... The first draft of the honey bee genome sequence and improved genetic maps are utilized to analyze a genome displaying 10 times higher levels of recombination (19 cM/Mb) than previously analyzed genomes of higher eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but v ...
... The first draft of the honey bee genome sequence and improved genetic maps are utilized to analyze a genome displaying 10 times higher levels of recombination (19 cM/Mb) than previously analyzed genomes of higher eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but v ...
Candidate gene scan for Single Nucleotide Polymorphisms involved
... soft facial tissue features are largely unknown. Numerous studies on animal models and ...
... soft facial tissue features are largely unknown. Numerous studies on animal models and ...
Chapter 1 - Illinois State University Department of Psychology
... and sex chromosomes differ? 2. What two types of instructions do genes provide? 3. What are genotype and phenotype? How are they related? 4. Describe the logic of twin studies and adoption studies. What general pattern of results would we predict for traits with genetic components? 5. What is Down s ...
... and sex chromosomes differ? 2. What two types of instructions do genes provide? 3. What are genotype and phenotype? How are they related? 4. Describe the logic of twin studies and adoption studies. What general pattern of results would we predict for traits with genetic components? 5. What is Down s ...
The Human Genome Project: Genetic Screening and the
... growing hair, while others are responsible for fighting off disease. These cells work together, enabling our bodies to act as a single entity-the human being.'0 But how do these cells know which tasks to perform and when? In 1953, James Watson and Francis Crick discovered that within the nucleus of ...
... growing hair, while others are responsible for fighting off disease. These cells work together, enabling our bodies to act as a single entity-the human being.'0 But how do these cells know which tasks to perform and when? In 1953, James Watson and Francis Crick discovered that within the nucleus of ...
Notes - hrsbstaff.ednet.ns.ca
... For example, farmers might selectively cross-pollinate a cold-hardy wheat with one that grows quicker in order to create a new variety that can survive in Canada's colder, shorter growing season. ...
... For example, farmers might selectively cross-pollinate a cold-hardy wheat with one that grows quicker in order to create a new variety that can survive in Canada's colder, shorter growing season. ...
List of references - UC Davis Plant Sciences
... of crop plants by marker-trait association: A case study for potatoes with quantitative variation of resistance to late blight and maturity type. ...
... of crop plants by marker-trait association: A case study for potatoes with quantitative variation of resistance to late blight and maturity type. ...
Genetic code redundancy and its influence on the encoded
... and NNU codons, the former are translated faster in C. elegans and HeLa cells. This result agrees well with what has been reported previously in E. coli [8]. As all NNC/NNU codon pairs are synonymous and can be decoded, in eukaryotes, either by WatsonCrick (G:C), near-Watson-Crick (I:C) or Wobble pa ...
... and NNU codons, the former are translated faster in C. elegans and HeLa cells. This result agrees well with what has been reported previously in E. coli [8]. As all NNC/NNU codon pairs are synonymous and can be decoded, in eukaryotes, either by WatsonCrick (G:C), near-Watson-Crick (I:C) or Wobble pa ...