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RNA Processing
RNA Processing

... – Is an important factor in determining the protein synthesis in a cell – Is determined in part by sequences in the leader and trailer regions ...
RNA processing
RNA processing

... – tRNA modifications include splicing, cleavage of sequences at the 5’ and 3’ end, and base modification – Mature rRNAs are cut out of a preribosomal primary transcript that includes one copy each of 18, 5.8 and 28S rRNA ...
Genome-Wide Analysis of Natural Selection on
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... regulatory elements (GREs) have a significant impact on evolution[2,3]. Since then, various lines of evidence have confirmed the functional impact of gene regulatory mutations[4]. The majority of known human polymorphisms occur in noncoding regions, many of which are likely to underlie gene expressi ...
Gene Therapy, Genetics and Epigenetics in Child Neurology
Gene Therapy, Genetics and Epigenetics in Child Neurology

... The three teams composing this new research are all well-recognized at the international level. Team 1 researchers are world-wide acknowledged, especially because of their pioneering gene therapy studies onleucodystrophies. The group leader of team 2 is a very well know physician and scientist, his ...
Biochemistry and Genetics of Tay-Sachs Disease
Biochemistry and Genetics of Tay-Sachs Disease

... splicing and consequent instability of the mRNA. 42 The effective result was absence of normal mRNA and, therefore, the absence of the a-subunit product. More significant than the actual identification of the mutation was the remarkable discovery that it was not the only one responsible for the infa ...
Human microRNA target analysis and gene ontology clustering by
Human microRNA target analysis and gene ontology clustering by

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Chapter 3 Proteins: - California State University San Marcos
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Chapter 19 (Eukaryotic Genome)
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Fulltext PDF - Indian Academy of Sciences
Fulltext PDF - Indian Academy of Sciences

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Mendel`s Principle of Independent Assortment
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... Many genes are present in 3 or more versions (alleles) – this is known as multiple alleles. The human ABO blood group is determined by three alleles (IA, IB, and i) of a single gene. The AB phenotype (genotype IA IB) is an example of ...
17-4 Patterns of Evolution
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... from the 5 subjects with multiple samples ranging from 0 to 7%) (Table 4). 3.3 The deleterious potential of the m.1644G>A mutation was demonstrated both in vivo with single muscle fibers analysis and ex vivo by its transfer into cybrid cells Analysis of isolated muscle fibers from Patient 2 showed t ...
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... alleles that continuously rise in frequency; and (ii) alleles that at first increase rapidly but whose frequencies then reach a plateau. Our data thus suggest that the genomic response to selection can involve a large number of selected SNPs that show unexpectedly complex evolutionary trajectories, ...
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Transcriptional Deregulation of Mutated BCL6 Alleles by Loss of
Transcriptional Deregulation of Mutated BCL6 Alleles by Loss of

... the BCL6 locus is altered by chromosomal translocations that deregulate its expression by a mechanism known as promoter substitution. In addition, the BCL6 5′ noncoding sequences are targeted by multiple somatic mutations that cluster within ~1.5 kb from the transcription initiation site and are fou ...
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Microevolution

Microevolution is the change in allele frequencies that occur over time within a population. This change is due to four different processes: mutation, selection (natural and artificial), gene flow, and genetic drift. This change happens over a relatively short (in evolutionary terms) amount of time compared to the changes termed 'macroevolution' which is where greater differences in the population occur.Population genetics is the branch of biology that provides the mathematical structure for the study of the process of microevolution. Ecological genetics concerns itself with observing microevolution in the wild. Typically, observable instances of evolution are examples of microevolution; for example, bacterial strains that have antibiotic resistance.Microevolution over time leads to speciation or the appearance of novel structure, sometimes classified as macroevolution. Macro and microevolution describe fundamentally identical processes on different scales.
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