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53 Gene Targeting in Human Somatic Cells
53 Gene Targeting in Human Somatic Cells

... of the gene products needed to carry out gene targeting. These events occur, however, at very low frequency due to the preferred usage of NHEJ. ...
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... chromosomal composition of a particular cell or organism – This allows the detection of individuals with abnormal chromosome number or structure – This also provides a way to distinguish between two closely-related species Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproducti ...
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horiuchi - Genetics
horiuchi - Genetics

... Synthesis of the phosphate binding protein (phoS gene product) is also derepressed during Pi starvation by wild-type strains (GAREN and OTSUJI1964; GERDES and ROSENBERG 1974). The mutants originally designated phoB do not derepress phosphate binding protein (WILLSKYand MALAMY 1976). Thus synthesis o ...
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Microevolution

Microevolution is the change in allele frequencies that occur over time within a population. This change is due to four different processes: mutation, selection (natural and artificial), gene flow, and genetic drift. This change happens over a relatively short (in evolutionary terms) amount of time compared to the changes termed 'macroevolution' which is where greater differences in the population occur.Population genetics is the branch of biology that provides the mathematical structure for the study of the process of microevolution. Ecological genetics concerns itself with observing microevolution in the wild. Typically, observable instances of evolution are examples of microevolution; for example, bacterial strains that have antibiotic resistance.Microevolution over time leads to speciation or the appearance of novel structure, sometimes classified as macroevolution. Macro and microevolution describe fundamentally identical processes on different scales.
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