Long noncoding RNAs and human disease - e
... metastasis [20]. The link between HOTAIR and metastatic disease depends on the direct interaction between RNA and its protein partner, and the association between RNA and its target DNA sequence. Therefore, altering HOTAIR levels results in enhanced PRC2 repressive activity in an anomalous set of me ...
... metastasis [20]. The link between HOTAIR and metastatic disease depends on the direct interaction between RNA and its protein partner, and the association between RNA and its target DNA sequence. Therefore, altering HOTAIR levels results in enhanced PRC2 repressive activity in an anomalous set of me ...
GENETICS PROBLEM AP
... Crossover frequencies were examined. Without crossover, half of the offspring would show all four dominant traits and half would show all four recessive traits. But this is not what happened. Some offspring had dominant A and recessive b, or recessive a and dominant B. Both of these were cou ...
... Crossover frequencies were examined. Without crossover, half of the offspring would show all four dominant traits and half would show all four recessive traits. But this is not what happened. Some offspring had dominant A and recessive b, or recessive a and dominant B. Both of these were cou ...
Slides
... §Caused by radiation, ROS, DNA damaging agents, or as result of replication errors §Repaired by two mechanisms: non-homologous end joining (NHEJ) and homologous recombination §NHEJ is error prone because there is no requirement for sequence homology §Recombination will be explained next ...
... §Caused by radiation, ROS, DNA damaging agents, or as result of replication errors §Repaired by two mechanisms: non-homologous end joining (NHEJ) and homologous recombination §NHEJ is error prone because there is no requirement for sequence homology §Recombination will be explained next ...
User`s Manual - Mendel`s Accountant
... population. Alternatively, template parameter settings for a small yeast population are also provided (these yeast parameters are only educated guesses - we have not researched what parameters would be most reasonable for yeast). These default parameters are readily altered to be applicable to any h ...
... population. Alternatively, template parameter settings for a small yeast population are also provided (these yeast parameters are only educated guesses - we have not researched what parameters would be most reasonable for yeast). These default parameters are readily altered to be applicable to any h ...
Correlated evolution (not coevolution!) Correlated character change
... Most neurotoxins affect the function of ion channels • Voltage-dependent K+ channels, Ca+ channels, and Na+ channels • The voltage-gated Na+ channel is targeted by diverse neurotoxins found widely in nature, of two types: Toxins that alter channel gating e.g. scorpion, anemone, and “arrow frog” toxi ...
... Most neurotoxins affect the function of ion channels • Voltage-dependent K+ channels, Ca+ channels, and Na+ channels • The voltage-gated Na+ channel is targeted by diverse neurotoxins found widely in nature, of two types: Toxins that alter channel gating e.g. scorpion, anemone, and “arrow frog” toxi ...
Genetics and Male Sexual Orientation
... (blind or otherwise) were used by Hamer and, in fact, the initial genotyping was performed by Hamer himself (8). Different individuals in the laboratory should perform different steps: phenotypic characterizations and genotypic analyses. We still contend that an X-linked gay gene could not exist in ...
... (blind or otherwise) were used by Hamer and, in fact, the initial genotyping was performed by Hamer himself (8). Different individuals in the laboratory should perform different steps: phenotypic characterizations and genotypic analyses. We still contend that an X-linked gay gene could not exist in ...
The Informational Gene and the Substantial Body: On the
... that evolution had occurred in nature and that natural selection is an important, perhaps the most important, mechanism of modification operating within generations. Darwin’s theory is commonly characterized as an “umbrella theory,” unifying explanations of diverse biological phenomena. However, man ...
... that evolution had occurred in nature and that natural selection is an important, perhaps the most important, mechanism of modification operating within generations. Darwin’s theory is commonly characterized as an “umbrella theory,” unifying explanations of diverse biological phenomena. However, man ...
Pattern of diversity in the genomic region near the
... ancestors) that constrained genome-wide levels of genetic diversity (hereafter referred to as ‘‘bottleneck effects’’). The severity of genetic loss ascribed to bottleneck effects varies greatly among crop species (1, 2). The second factor to have an impact on crop genomes is selection for the agrono ...
... ancestors) that constrained genome-wide levels of genetic diversity (hereafter referred to as ‘‘bottleneck effects’’). The severity of genetic loss ascribed to bottleneck effects varies greatly among crop species (1, 2). The second factor to have an impact on crop genomes is selection for the agrono ...
Identifying a Novel Isoform of the AZIN1 Gene by Combining High
... can be used to find similar RNA-related events among other known genes. For example, Illumina RNA-seq detected the known isoforms of the AZIN1 gene, which were then compared with the new isoform that was found using PacBio. This suggests that combining high-throughput technologies may be more effect ...
... can be used to find similar RNA-related events among other known genes. For example, Illumina RNA-seq detected the known isoforms of the AZIN1 gene, which were then compared with the new isoform that was found using PacBio. This suggests that combining high-throughput technologies may be more effect ...
RECOMBINEERING: A POWERFUL NEW TOOL FOR MOUSE
... genes with known function, this will be a daunting task. Much of our understanding of these genes will therefore have to come from studies of model organisms. The mouse is an ideal model organism for these types of study. Not only are the mouse and human genomes very similar, but also transgenic and ...
... genes with known function, this will be a daunting task. Much of our understanding of these genes will therefore have to come from studies of model organisms. The mouse is an ideal model organism for these types of study. Not only are the mouse and human genomes very similar, but also transgenic and ...
Genetics Jeopardy
... Two short-tailed (Manx) cats are bred together. They produce three kittens with long tails, five short tails, and two without any tails. From these results, how do you think tail length in these cats are inherited? Show the genotypes for both the parents and the offspring to support your answer. ...
... Two short-tailed (Manx) cats are bred together. They produce three kittens with long tails, five short tails, and two without any tails. From these results, how do you think tail length in these cats are inherited? Show the genotypes for both the parents and the offspring to support your answer. ...
as Microsoft Word - Edinburgh Research Explorer
... supposition largely borne out by ectopic expression studies13. ...
... supposition largely borne out by ectopic expression studies13. ...
Week 30B, Monday Time Lesson/Activity Materials 8:15 8:50
... hereditary information and transfer it to the next generation; they occur in nearly identical pairs in the nucleus of every cell. Content 03. Genes are the basic units of heredity carried by chromosomes. Genes code for features of organisms. Content 04. Alleles are variations of genes that determine ...
... hereditary information and transfer it to the next generation; they occur in nearly identical pairs in the nucleus of every cell. Content 03. Genes are the basic units of heredity carried by chromosomes. Genes code for features of organisms. Content 04. Alleles are variations of genes that determine ...
GENETIC CONSTRAINTS ON ADAPTATION TO A CHANGING
... in phenotypic selection. First for most organisms, many aspects of their environment, either abiotic (temperature, precipitation) or biotic (density of competitors, predators, parasites. . .) vary between generations. Second, population sizes often fluctuate substantially, even for organisms with vi ...
... in phenotypic selection. First for most organisms, many aspects of their environment, either abiotic (temperature, precipitation) or biotic (density of competitors, predators, parasites. . .) vary between generations. Second, population sizes often fluctuate substantially, even for organisms with vi ...
Mendel and Punnett squares notes
... segregate in the formation of gametes. When two gametes combine during fertilization, the offspring have two factors controlling a specific trait. • Law of Independent Assortment: states that factors for different characteristics are distributed to gametes independently. ...
... segregate in the formation of gametes. When two gametes combine during fertilization, the offspring have two factors controlling a specific trait. • Law of Independent Assortment: states that factors for different characteristics are distributed to gametes independently. ...
cancer, genes and inherited predisposition
... developing cancer. A small number of people inherit from a parent a change in one of the copies of one of their ‘cancer protection’ genes that makes the gene copy faulty. If a child is born with one copy of a ‘cancer protection’ gene that is already faulty, the child has inherited from a parent a hi ...
... developing cancer. A small number of people inherit from a parent a change in one of the copies of one of their ‘cancer protection’ genes that makes the gene copy faulty. If a child is born with one copy of a ‘cancer protection’ gene that is already faulty, the child has inherited from a parent a hi ...
Arabidopsis thaliana Arabidopsis thaliana
... have related genes in other eukaryotic genomes, reflecting the independent evolution of many plant transcription factors. In contrast, 48 ± 60% of genes involved in protein synthesis have counterparts in the other eukaryotic genomes, reflecting highly conserved gene functions. The relatively high pr ...
... have related genes in other eukaryotic genomes, reflecting the independent evolution of many plant transcription factors. In contrast, 48 ± 60% of genes involved in protein synthesis have counterparts in the other eukaryotic genomes, reflecting highly conserved gene functions. The relatively high pr ...
Epigenetics in mood disorders
... It is clear that both genes and the environment confer risk for mood disorders. A relative recent development in the field of biological psychiatry has been the focus on attempts to understand functional outcomes of the additive and combinatorial effects of genes and the environment at the molecular ...
... It is clear that both genes and the environment confer risk for mood disorders. A relative recent development in the field of biological psychiatry has been the focus on attempts to understand functional outcomes of the additive and combinatorial effects of genes and the environment at the molecular ...
MS26/CYP704B is required for anther and pollen wall
... requisite permission from any third-party owners of all or parts of the materials and to governmental regulation considerations. Obtaining the applicable permission from such third-party owners will be the responsibility of the requestor. Transgenic materials reported in this paper would only be mad ...
... requisite permission from any third-party owners of all or parts of the materials and to governmental regulation considerations. Obtaining the applicable permission from such third-party owners will be the responsibility of the requestor. Transgenic materials reported in this paper would only be mad ...
View poster
... Structural variations in the genome can be determined from NGS data with either whole genome sequencing (WGS) or targeted enrichment using exome or gene panels. Copy number variation (CNV) of genomic segments is a large category of structural variation and has been implicated in many Mendelian disea ...
... Structural variations in the genome can be determined from NGS data with either whole genome sequencing (WGS) or targeted enrichment using exome or gene panels. Copy number variation (CNV) of genomic segments is a large category of structural variation and has been implicated in many Mendelian disea ...
S4O3 Pretest 2015-2016
... 59. Review the prokaryotic trp operon. If you were going to create a mutation that would cause the least amount of damage to the bacterium, what type of mutation would you choose? Would you locate it in the repressor, the promoter, or somewhere else? Give reasons for your answer. Agrobacterium tume ...
... 59. Review the prokaryotic trp operon. If you were going to create a mutation that would cause the least amount of damage to the bacterium, what type of mutation would you choose? Would you locate it in the repressor, the promoter, or somewhere else? Give reasons for your answer. Agrobacterium tume ...
Tracking bacterial DNA replication forks in vivo by pulsed field gel
... 20% of the chromosome is devoid of Not I sites (i.e. compare 1000 kb with 868 kb). In addition, the experiments described below will show that the DNA replication origin and terminus as well as the genes described above appear to be arranged in a similar manner in the two isolates (K12 and 15). Iden ...
... 20% of the chromosome is devoid of Not I sites (i.e. compare 1000 kb with 868 kb). In addition, the experiments described below will show that the DNA replication origin and terminus as well as the genes described above appear to be arranged in a similar manner in the two isolates (K12 and 15). Iden ...
Where Is DNA Found?
... Greater automation of the DNA typing process Use of SNP’s—single nucleotide polymorphism which measures a one nucleotide change or difference from one individual to another. More sites are needed to differentiate between individuals (30 to 50 SNPs to attain the frequencies of the 13 STR loci), b ...
... Greater automation of the DNA typing process Use of SNP’s—single nucleotide polymorphism which measures a one nucleotide change or difference from one individual to another. More sites are needed to differentiate between individuals (30 to 50 SNPs to attain the frequencies of the 13 STR loci), b ...
The case for transgenerational epigenetic inheritance in humans
... sensitive to environmental influences. Moreover, in some cases the epigenetic state at these alleles can survive across generations, termed transgenerational epigenetic inheritance. Together these findings raise the spectre of Lamarckism and epigenetics is now being touted as an explanation for some ...
... sensitive to environmental influences. Moreover, in some cases the epigenetic state at these alleles can survive across generations, termed transgenerational epigenetic inheritance. Together these findings raise the spectre of Lamarckism and epigenetics is now being touted as an explanation for some ...
B 1 = B 2
... If either of the following occurs then the population is responding to selection. 1. Some phenotypes allow greater survival to reproductive age. -or2. All individuals reach reproductive age but some individuals are able to produce more viable (reproductively successful) offspring. If these differenc ...
... If either of the following occurs then the population is responding to selection. 1. Some phenotypes allow greater survival to reproductive age. -or2. All individuals reach reproductive age but some individuals are able to produce more viable (reproductively successful) offspring. If these differenc ...