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Supplementary Information (doc 63K)
Supplementary Information (doc 63K)

... was used to test the newly designed RT-MLPA. TP53 and ATM molecular status was determined using FISH and sequencing. Only samples with biallelic TP53 (TP53 mutation + 17p deletion) and biallelic ATM (ATM mutation + 11q deletion) defects were included. In addition, TP53-mutant CLL samples were to a l ...
Deep Insight Section Spatial arrangement of the human genome and its
Deep Insight Section Spatial arrangement of the human genome and its

... al., 1998). On the other hand, association with the nuclear periphery is not sufficient if the reporter construct has no silencer element (Gasser, 2001). Radial nuclear distributions, illustrating nuclear topography of high gene density (expression) and low gene density regions of chromosomes, are s ...
Gene Section ERG (v-ets erythroblastosis virus E26 oncogene like (avian))
Gene Section ERG (v-ets erythroblastosis virus E26 oncogene like (avian))

... endothelial cells. In the GNF SymAtlas database, the major ERG expression was found to be in CD34+ cells (that include both hematopoietic stem cells and endothelial cells). ERG was also reported to be expressed in during early T and B cell development, and to be down-regulated in later stages of B a ...
Using Transgenic Technology to Characterize Regulatory Regions
Using Transgenic Technology to Characterize Regulatory Regions

... Homeotic selector genes (Hox) 4 gene clusters with 9-11 genes each  Control development of body segments  Used Hox genes of Drosophila as probes in ...
Systematic analysis of gene properties influencing organ system
Systematic analysis of gene properties influencing organ system

... For example, several topological properties of genes in protein–protein interaction networks such as betweenness centrality (hereafter named betweenness) have been associated with lethality (Goh et al., 2007; Jeong et al., 2001). Moreover, tissue gene expression and cellular localization of genes ha ...
1 - SMIC Biology
1 - SMIC Biology

... While genotype will influence phenotype, remember that environmental factors can also influence how/whether a gene is expressed. (Read about western white butterflies on page 321.) Remember that humans have (#?) chromosomes in every cell. Of these, pairs are autosomes. An autosome is any chromosome ...
Six3, a murine homologue of the sine oculis gene, demarcates the
Six3, a murine homologue of the sine oculis gene, demarcates the

... (Oliver et al., 1995). The expression of these genes was found to be restricted mainly to head and body mesenchyme, limb muscle and tendons. In an attempt to identify additional Six-related homeobox genes specifically expressed in the CNS, an E14.5 brain cDNA library was screened at low stringency u ...
Chapter 24
Chapter 24

Punnett Wrkst
Punnett Wrkst

... Genetics Worksheet The Punnett Square: The Punnett square is a chart, used by geneticists, to help determine the chances of an offspring receiving a particular characteristic. The Punnett square will not tell you how many offspring will develop, or the order in which they will be born. B = brown hai ...
Introduction: The Domestication of Plants and Animals: Ten
Introduction: The Domestication of Plants and Animals: Ten

... descendant relationships, but also to gene flow from the domesticated to the wild gene pool. This type of gene flow is more frequent than generally assumed (Ellstrand et al. 1999). Because agriculture represents a production system in which several crops (and farm animals) are assembled, joint infor ...
Are 100 enough? Inferring acanthomorph teleost phylogeny using
Are 100 enough? Inferring acanthomorph teleost phylogeny using

... this gives rise to the uncertainty as to whether the sequences aligned in a phylogenetic matrix are orthologous. This is of particular concern in teleost fishes, where there has been a whole genome duplication event (WGD) prior to the diversification of all living teleosts [28, 29]. An alignment wit ...
At CSIRO: Studying a Specific Change in One Gene of the Avian Flu
At CSIRO: Studying a Specific Change in One Gene of the Avian Flu

... chickens to the authorities, because proper reimbursement for them may not be made. This is also a problem of education. Even if the bird flu did not cause high levels of mortality in humans, but spread like a regular flu, it would have a profound economic effect. The World Bank has estimated that a ...
Genetic Analyses of Agronomic Traits Controlled by Wheat
Genetic Analyses of Agronomic Traits Controlled by Wheat

... determined by heading date; however, none of the previous research was designed to determine the number of loci affecting the trait. A unimodal normal distribution was observed for grain yield, kernel number per spike, kernel weight, spike number per square meter, grain volume weight, and plant heig ...
Congenital myasthenic syndromes (CMS)
Congenital myasthenic syndromes (CMS)

... different genetic defects in a series of different genes can cause CMS. These defects cause problems with the way the messages are transmitted from the nerves to the muscles, causing weakness (myasthenia) and the muscles tire easily (fatigue). Muscle weakness varies depending on the type of genetic ...
Inheritance of Aldehyde Oxidase in Drosophila melanogaster
Inheritance of Aldehyde Oxidase in Drosophila melanogaster

... 2, 3, and 4. The 2, 3, and 4 chromosomes are the same in both sexes and are referred to as autosomes to distinguish them from the X and Y sex chromosomes. Female Drosophila are characterized by having two X chromosomes while male Drosophila have an X and a Y chromosome. The Y chromosome only has gen ...
Protein quality of wheat cultivars grown in eastern Croatia in relation
Protein quality of wheat cultivars grown in eastern Croatia in relation

... generation means did not fit a simple epistatic model which indicated that improvement of traits studied would be more difficult as compared to the situation pertaining to more simple models of inheritance (additive-dominance and digenic epistatic model). These results are in accordance with reports ...
2016 HSC Biology Marking Guidelines
2016 HSC Biology Marking Guidelines

... Sample answer: Haemoglobin is a protein that provides a mechanism for efficient transport of oxygen around the body. It increases the amount of oxygen that can be carried in the blood stream as one single haem unit is able to carry four oxygen molecules. Species A and Species B have different haemog ...
Congenital myasthenic syndromes
Congenital myasthenic syndromes

... different genetic defects in a series of different genes can cause CMS. These defects cause problems with the way the messages are transmitted from the nerves to the muscles, causing weakness (myasthenia) and the muscles tire easily (fatigue). Muscle weakness varies depending on the type of genetic ...
Genetics
Genetics

... formation of gametes (reproductive cells), pairs of allele for a specific trait separate so that offspring receive one factor from each parent. ...
The global repressor FliZ antagonizes gene
The global repressor FliZ antagonizes gene

... integrases and recombinases (Supplementary Figure S2A) (21,22) and recent publications indicate that FliZ acts as a DNA-binding regulator in other bacterial species (23). This suggested that the ability of FliZ to antagonize sS-dependent gene expression (10) might be due to binding to sS-controlled ...
Document
Document

... BioPhysics 101 Biology section #2 Today’s topics: •Dogmas •Operons •Cis and Trans •Haplotypes ...
Postzygotic isolation in Drosophila simulans and D. mauritiana
Postzygotic isolation in Drosophila simulans and D. mauritiana

... reproductively isolated. Species can be isolated due to barriers that occur before zygote formation (pre-zygotic isolation) or after zygote formation (post-zygotic isolation). In this chapter I review the types of species isolating barriers, and I critically examine different models of reproductive ...
Chapter 10 Information Transfer in Cells Information Transfer in Cells
Chapter 10 Information Transfer in Cells Information Transfer in Cells

... molecules are not only informational – they can also be catalytic • This gave evidence to the postulate by Francis Crick and others that prebiotic evolution (that is, early evolution before cells arose) depended on self-replicating, catalytic RNAs • But what was the origin of the nucleotides? • A li ...
Chapter 10
Chapter 10

... molecules are not only informational – they can also be catalytic • This gave evidence to the postulate by Francis Crick and others that prebiotic evolution (that is, early evolution before cells arose) depended on self-replicating, catalytic RNAs • But what was the origin of the nucleotides? • A li ...
Full Text
Full Text

... AMD has been described. It appears that genetic changes in the HTRA1 gene promoter in the 10q26 chromosomal region are related to the pathogenesis of AMD. Polymorphisms rs2672598 -487T>C and rs11200638 -625 G>A in this region have been demonstrated to be associated with an increased risk of developi ...
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Microevolution

Microevolution is the change in allele frequencies that occur over time within a population. This change is due to four different processes: mutation, selection (natural and artificial), gene flow, and genetic drift. This change happens over a relatively short (in evolutionary terms) amount of time compared to the changes termed 'macroevolution' which is where greater differences in the population occur.Population genetics is the branch of biology that provides the mathematical structure for the study of the process of microevolution. Ecological genetics concerns itself with observing microevolution in the wild. Typically, observable instances of evolution are examples of microevolution; for example, bacterial strains that have antibiotic resistance.Microevolution over time leads to speciation or the appearance of novel structure, sometimes classified as macroevolution. Macro and microevolution describe fundamentally identical processes on different scales.
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