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Chapter 12 - Inheritance Patterns and Human Genetics
Chapter 12 - Inheritance Patterns and Human Genetics

... b. one pair different in males 1) chromosome same in both sexes called X shorter, hooked shaped one in male called Y 2) hypothesized them to be sex chromosomes (determine sex) c. males XY and females XX 1) male gametes contain X or Y , female only X 2. Sex Linkage (Morgan) (showed that specific gene ...
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CHAPTER 8 (CHOMOSOME MUTATION: CHANGES IN

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Chapter 15 - The Chromosomal Basis of Inheritance

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X-inactivation



X-inactivation (also called lyonization) is a process by which one of the two copies of the X chromosome present in female mammals is inactivated. The inactive X chromosome is silenced by its being packaged in such a way that it has a transcriptionally inactive structure called heterochromatin. As nearly all female mammals have two X chromosomes, X-inactivation prevents them from having twice as many X chromosome gene products as males, who only possess a single copy of the X chromosome (see dosage compensation). The choice of which X chromosome will be inactivated is random in placental mammals such as humans, but once an X chromosome is inactivated it will remain inactive throughout the lifetime of the cell and its descendants in the organism. Unlike the random X-inactivation in placental mammals, inactivation in marsupials applies exclusively to the paternally derived X chromosome.
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