IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)
... From the results shown in accuracy table-2 it was found that the percent recovery values of pure drug from the preanalysed solutions of formulations were in between 98.3% -100.16%, which indicates that the method is accurate and which reveals that commonly used excipients and additives present in th ...
... From the results shown in accuracy table-2 it was found that the percent recovery values of pure drug from the preanalysed solutions of formulations were in between 98.3% -100.16%, which indicates that the method is accurate and which reveals that commonly used excipients and additives present in th ...
micronization and dissolution enhancement of norethindrone
... showed significant lower dissolution in 45 minutes and this led an impetus to search for an appropriate formulation that can give better dissolution profile. Mechanical methods of micronization are simple, efficient and cost effective way of achieving particle size reduction. The formulation develop ...
... showed significant lower dissolution in 45 minutes and this led an impetus to search for an appropriate formulation that can give better dissolution profile. Mechanical methods of micronization are simple, efficient and cost effective way of achieving particle size reduction. The formulation develop ...
Chapter-3 Drug and excipients profile
... magnesium hydroxide carries away much of the body's supply of potassium, and failure to take extra potassium may lead to muscle cramps. Magnesium hydroxide is also used as an antiperspirant armpit deodorant. Milk of magnesia is useful against canker sores (aphthous ulcer) when used topically. Milk o ...
... magnesium hydroxide carries away much of the body's supply of potassium, and failure to take extra potassium may lead to muscle cramps. Magnesium hydroxide is also used as an antiperspirant armpit deodorant. Milk of magnesia is useful against canker sores (aphthous ulcer) when used topically. Milk o ...
Memorandum 0861 ‘03 tIAR-3 I’130
... noti@ the Food and Drug Administration that Threshold will market a new dietary ingredient Idebenone, a synthetic analog of Coenzyme QlO (Ubiquinone), a universally accepted and safe dietary supplement. Accordingly, we are submitting this original and two (2) copies of this notification. The dietary ...
... noti@ the Food and Drug Administration that Threshold will market a new dietary ingredient Idebenone, a synthetic analog of Coenzyme QlO (Ubiquinone), a universally accepted and safe dietary supplement. Accordingly, we are submitting this original and two (2) copies of this notification. The dietary ...
(Received on 27 /7/2005) (Accepted for publication on 29/4 /2006)
... been developed for the quantitative determination of amlodipine in human plasma . The drug plasma concentrations were determined by deactivated reversed-phase (250 X 4.6 mm I.d) C18-DB column, 5 µm particle size, 7125 Rheodyne injector was used, using THF :buffer phosphate as mobile phase. Amlodipin ...
... been developed for the quantitative determination of amlodipine in human plasma . The drug plasma concentrations were determined by deactivated reversed-phase (250 X 4.6 mm I.d) C18-DB column, 5 µm particle size, 7125 Rheodyne injector was used, using THF :buffer phosphate as mobile phase. Amlodipin ...
Presentation - Poorly water soluble substances: challenges
... • neurotoxic, adverse CNS effects, children below 6 years more susceptible, effects on developing brain! (prematures, neonates, infants) • exposure should be assessed as potential blood level after ingestion • CNS effects reported already at 0.01 g/L • What is a safe level after single dose/over tre ...
... • neurotoxic, adverse CNS effects, children below 6 years more susceptible, effects on developing brain! (prematures, neonates, infants) • exposure should be assessed as potential blood level after ingestion • CNS effects reported already at 0.01 g/L • What is a safe level after single dose/over tre ...
Validated RP-HPLC Method for Concurrent Determination of
... greater precision and accuracy to quantify phenytoin sodium and clopidogrel bisulphate in tablet dosage form. Chromatographic separation was achieved on a phenomenex, Luna C18 (150 × 4.6 mm), i.d. 5µm) column in isocratic mode with a mobile phase consisting of acetonitrile and water with 0.1% triflu ...
... greater precision and accuracy to quantify phenytoin sodium and clopidogrel bisulphate in tablet dosage form. Chromatographic separation was achieved on a phenomenex, Luna C18 (150 × 4.6 mm), i.d. 5µm) column in isocratic mode with a mobile phase consisting of acetonitrile and water with 0.1% triflu ...
UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ONDANSETRON
... A simple, rapid, precise, accurate and sensitive analytical method was developed for the UV spectrophotometric assay of ondansetron. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 248 nm in saline. The linearity was observed between 5 – 25 µg mL-1. The res ...
... A simple, rapid, precise, accurate and sensitive analytical method was developed for the UV spectrophotometric assay of ondansetron. The drug obeyed the Beer’s law and showed good correlation. It showed absorption maxima at 248 nm in saline. The linearity was observed between 5 – 25 µg mL-1. The res ...
Pharmaceutical Excipients
... Formulary (NF), and USP Reference Standards. The agents that are currently being used in the pharmaceutical field as a very important excipients are discussed below. ...
... Formulary (NF), and USP Reference Standards. The agents that are currently being used in the pharmaceutical field as a very important excipients are discussed below. ...
Chapter 5 Drugs for Neoplastic Disorders
... important role technicians have in identifying problem OTC purchases. The technician is often in a position to prevent many potentially serious complications from inappropriate OTC drug use. Often the patient will bring an OTC product to the counter when picking up prescriptions, and the technician ...
... important role technicians have in identifying problem OTC purchases. The technician is often in a position to prevent many potentially serious complications from inappropriate OTC drug use. Often the patient will bring an OTC product to the counter when picking up prescriptions, and the technician ...
Evaluation for Zero-order Controlled Release Preparations of
... this was not found in the case of the branded drug. Further examination may be necessary to determine the long-term in‰uence of such residue. To assess stability, worst-case tests in open containers are demanded for branded drugs, but only an accelerated test is required for generic drugs at the tim ...
... this was not found in the case of the branded drug. Further examination may be necessary to determine the long-term in‰uence of such residue. To assess stability, worst-case tests in open containers are demanded for branded drugs, but only an accelerated test is required for generic drugs at the tim ...
SIMULTANEOUS UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF ATENOLOL AND AMLODIPINE BESYLATE IN COMBINED TABLET DOSAGE FORM
... observed at 232.2 nm. These wavelengths were selected for simultaneous estimation and Q analysis of ATN and AMN and are assumed to be sensitive wavelengths. Standard calibration curves for ATN and AMN were linear with correlation coefficient of 0.9972‐ 0.9987 at all selec ...
... observed at 232.2 nm. These wavelengths were selected for simultaneous estimation and Q analysis of ATN and AMN and are assumed to be sensitive wavelengths. Standard calibration curves for ATN and AMN were linear with correlation coefficient of 0.9972‐ 0.9987 at all selec ...
STABILITY INDICATING HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF TELMISARTAN AND RAMIPRIL IN TABLETS
... silica gel 60F254 HPTLC plates using mobile phase comprising of toluene: acetonitrile: formic acid: methanol in the ratio of 5:5:0.3:1(v/v/v/v). The plates were prewashed with methanol and activated in an oven at 600C for 1 hour before use. The sample solution ...
... silica gel 60F254 HPTLC plates using mobile phase comprising of toluene: acetonitrile: formic acid: methanol in the ratio of 5:5:0.3:1(v/v/v/v). The plates were prewashed with methanol and activated in an oven at 600C for 1 hour before use. The sample solution ...
KETOCONAZOLE TABLETS USP 200 mg Rx Only WARNING
... has been about 1:10,000 exposed patients, but this probably represents some degree of under-reporting, as is the case for most reported adverse reactions to drugs. The median duration of Ketoconazole Tablet therapy in patients who developed symptomatic hepatotoxicity was about 28 days, although the ...
... has been about 1:10,000 exposed patients, but this probably represents some degree of under-reporting, as is the case for most reported adverse reactions to drugs. The median duration of Ketoconazole Tablet therapy in patients who developed symptomatic hepatotoxicity was about 28 days, although the ...
LABEL Infopest Verified
... Carprofen is eliminated in the dog primarily by biotransformation in the liver followed by rapid excretion of the resulting metabolites (the ester glucuronide of carprofen and the ether glucuronides of 2 phenolic metabolites, 7-hydroxy carprofen and 8-hydroxy carprofen) in the faeces (70–80%) and ur ...
... Carprofen is eliminated in the dog primarily by biotransformation in the liver followed by rapid excretion of the resulting metabolites (the ester glucuronide of carprofen and the ether glucuronides of 2 phenolic metabolites, 7-hydroxy carprofen and 8-hydroxy carprofen) in the faeces (70–80%) and ur ...
Using ACE Inhibitors To Treat
... a Consumers Union and Consumer Reports project to help you find safe, effective medicines that give you the most value for your healthcare dollar. To learn more about the project and other drugs we’ve evaluated, go to ConsumerReportsHealth.org/BestBuyDrugs. ACEIs are used by millions of people every ...
... a Consumers Union and Consumer Reports project to help you find safe, effective medicines that give you the most value for your healthcare dollar. To learn more about the project and other drugs we’ve evaluated, go to ConsumerReportsHealth.org/BestBuyDrugs. ACEIs are used by millions of people every ...
11346009
... volume of 10µL and eluted by the mobile phase of 0.02 M potassium dihydrogen phosphate (pH4) and acetonitrile in a ratio of 60:40 respectively, which is pumped at a flow rate of 1.0 mL/min. The method carried out the detection at a wavelength of 252 nm for the binary mixture and of 210 nm for the si ...
... volume of 10µL and eluted by the mobile phase of 0.02 M potassium dihydrogen phosphate (pH4) and acetonitrile in a ratio of 60:40 respectively, which is pumped at a flow rate of 1.0 mL/min. The method carried out the detection at a wavelength of 252 nm for the binary mixture and of 210 nm for the si ...
Study Session 8 Malaria Case Management
... your own stock (not from the tablets you give to the patient or the mother/caregiver to take home) and let the patient swallow it. If a child vomits within 30 minutes of taking drugs at home, advise the patient/caregiver to take another dose, and to come back to the Health Post to collect another r ...
... your own stock (not from the tablets you give to the patient or the mother/caregiver to take home) and let the patient swallow it. If a child vomits within 30 minutes of taking drugs at home, advise the patient/caregiver to take another dose, and to come back to the Health Post to collect another r ...
10.4103-0975-1483.93570
... Determination of amount of cephalexin to be used in a tablet Cephalexin is available as a hydrous molecule cephalexin monohydrate. Labeled claims are to be expressed in terms of the equivalent amount of anhydrous cephalexin present in the dosage form. The quality control department analyses the raw ...
... Determination of amount of cephalexin to be used in a tablet Cephalexin is available as a hydrous molecule cephalexin monohydrate. Labeled claims are to be expressed in terms of the equivalent amount of anhydrous cephalexin present in the dosage form. The quality control department analyses the raw ...
GASTRO-RETENTIVE DRUG DELIVERY SYSTEM CONTENTS
... intrinsic rate of emptying. Unfortunately floating devices administered in a single unit form ( Hydrodynamically balanced system) HBS are unreliable in prolonging the GRT owing to their ‘ all- or- nothing’ emptying process and, thus they may causes high variability in bioavailibity and local irritat ...
... intrinsic rate of emptying. Unfortunately floating devices administered in a single unit form ( Hydrodynamically balanced system) HBS are unreliable in prolonging the GRT owing to their ‘ all- or- nothing’ emptying process and, thus they may causes high variability in bioavailibity and local irritat ...
SIMULTANEOUS DETERMINATION AND VALIDATION OF AMOLODIPINE AND METAPROLOL
... mg/day Metoprolol tartrate was developed by Novartis and received approval in the United States August 7, 1978.Generic metoprolol succinate was developed by Sandoz and received approval in the United States on July 31, 2006. It is marketed under the brand name Lopressor by Novartis, and Toprol-XL (i ...
... mg/day Metoprolol tartrate was developed by Novartis and received approval in the United States August 7, 1978.Generic metoprolol succinate was developed by Sandoz and received approval in the United States on July 31, 2006. It is marketed under the brand name Lopressor by Novartis, and Toprol-XL (i ...
design and evaluation of fast dissolving oral films of
... reformulating existing drugs into new dosage forms. One such relatively new dosage form is the fast dissolving oral film. The oral mucosa being a highly vascularized, drugs can be absorbed directly and can enter the systemic circulation without undergoing first‐pass hepatic metabolism.1 Fast dissolv ...
... reformulating existing drugs into new dosage forms. One such relatively new dosage form is the fast dissolving oral film. The oral mucosa being a highly vascularized, drugs can be absorbed directly and can enter the systemic circulation without undergoing first‐pass hepatic metabolism.1 Fast dissolv ...
15. Recent Trends in Sustained Release Drug Delivery System
... In this method weighed quantities of drug and polymer are mixed with sufficient volume of granulating agent. After enough cohesiveness was obtained, then screening of wet mass. The granules are dried and screening of dry granules, then blending with lubricant and disintegrant to produce “running pow ...
... In this method weighed quantities of drug and polymer are mixed with sufficient volume of granulating agent. After enough cohesiveness was obtained, then screening of wet mass. The granules are dried and screening of dry granules, then blending with lubricant and disintegrant to produce “running pow ...
to Print Topic Help File ,
... Release of the medication into the stomach may render the medication inactive or may irritate the stomach lining. ...
... Release of the medication into the stomach may render the medication inactive or may irritate the stomach lining. ...
PHYSICIANS` PRESCRIBING INFORMATION
... temporarily, Dopicar may be restarted as soon as oral medication can be taken at the same daily dosage as before. Epidemiological studies have shown that patients with Parkinson's disease have a higher risk of developing melanoma than the general population (approximately 2-6 fold higher). It is unc ...
... temporarily, Dopicar may be restarted as soon as oral medication can be taken at the same daily dosage as before. Epidemiological studies have shown that patients with Parkinson's disease have a higher risk of developing melanoma than the general population (approximately 2-6 fold higher). It is unc ...
Tablet (pharmacy)
A tablet is a pharmaceutical dosage form. Tablets may be defined as the solid unit dosage form of medicament or medicaments with or without suitable diluents and prepared either by molding or by compression. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf life), or to enhance the tablet's appearance.The compressed tablet is the most popular dosage form in use today. About two-thirds of all prescriptions are dispensed as solid dosage forms, and half of these are compressed tablets. A tablet can be formulated to deliver an accurate dosage to a specific site; it is usually taken orally, but can be administered sublingually, buccally, rectally or intravaginally. The tablet is just one of the many forms that an oral drug can take such as syrups, elixirs, suspensions, and emulsions. Medicinal tablets were originally made in the shape of a disk of whatever color their components determined, but are now made in many shapes and colors to help distinguish different medicines. Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified. Sizes of tablets to be swallowed range from a few millimeters to about a centimeter.