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1. Islet 2. Pancreatic lymph node
1. Islet 2. Pancreatic lymph node

... Emergence of the concept of Antigen Specific Immunotherapy (ASI) for autoimmune disease “The administration of auto-antigen in a form or by a route designed to induce or re-establish tolerance to the same antigen or to the target tissues of the autoimmune response” ...
Slide 1
Slide 1

... Emergence of the concept of Antigen Specific Immunotherapy (ASI) for autoimmune disease “The administration of auto-antigen in a form or by a route designed to induce or re-establish tolerance to the same antigen or to the target tissues of the autoimmune response” ...
Immunity
Immunity

... Humoral response ...
Immune System Reading and Questions
Immune System Reading and Questions

... pathogens and formulate a new immune response to deal with new invaders as they arrive. This new response is then retained after the pathogen is eliminated in the form of an immunological memory. This memory allows the adaptive immune system to launch quick and decisive attacks against any repeat of ...
No Slide Title - Pegasus @ UCF
No Slide Title - Pegasus @ UCF

... Table 15.5 Immunology Review Immunoglobulins IgC most abundant Ig of internal body fluids, particularly extravascular. Where they combat micro-organisms and their toxins IgA major Ig insero-mucus secretions where it defends external body surfaces IgM very effective agglutinator; produced early in i ...
Organs of Immune system
Organs of Immune system

... • Bone Marrow is a loosely-organized grouping of cells located in central soft tissue portion of long bones. • Bone marrow is the seat of Hematopoiesis i. e., production of blood cells • All the cells present in blood (WBCs and RBCs) are derived from hematopoietic stem cells present in Bone Marrow. ...
Immune System notes fill-in
Immune System notes fill-in

... o Function: Trap and remove pathogens and other foreign materials that adenoids? enter the ___________________________ o Adenoids, like the thymus, shrink with age ...
Chapter 39 - The Body Defenses
Chapter 39 - The Body Defenses

... 2. Attack infected “self” cells 3. Differentiation into several cell types: A) Cytotoxic T-cells B) Helper T-cells C) Suppressor T-cells D) Memory T-cells Cytotoxic T-cells 1. Destroy infected “self” cells via secretion of perforin 2. Perforin (perforating) creates holes in the target cell’s membran ...
B-LYMPHOCYTES
B-LYMPHOCYTES

... VARIABLE REGION OF ANTIBODIES •At the tip of the arms of the Y-shape. •Variable region has the potential to bind with particular classes of antigens. •Once a raw antibody is stimulated to fit to a specific antigen, it can then react with ONLY that antigen. This is known as SINGLE SPECIFICITY. •Can ...
Dr. JL Jarry
Dr. JL Jarry

... This stimulates the B-cell to undergo clonal expansion B-cells divide into plasma cells Plasma cells mass-produce antibodies Antibodies circulate, find antigens, bind to them, and mark them for latter destruction • The destruction is then carried out by phagocytes • Some B-cells become memory cells ...
Hairy cell leukemia is a chronic Lymphoprolifrative disorder. in 1952
Hairy cell leukemia is a chronic Lymphoprolifrative disorder. in 1952

... A small proportion (<5%) of patients with HCL do not require therapy. Splenectomy, often used in the past as the first treatment of most patients two thirds of patients, usually within 1 to 4 weeks, but does not decrease the infiltration of hairy cells in the marrow or reduce the incidence of infec ...
Review for Quarter 1 10-29-2013
Review for Quarter 1 10-29-2013

... A lymphocyte is another word for white blood cell; there are Tcells, and B-cells. ...
Mary Louise Markert, MD, Ph.D.
Mary Louise Markert, MD, Ph.D.

... immune system from attacking and rejecting the transplant. These children require close medical supervision to avoid infections, tumors, kidney damage and heart disease and a high rate of rejection caused by non-compliance in taking the necessary immunosuppressive drugs. To address this unmet need, ...
LEUKOPOIESIS LEARNING OBJECTIVES • To classify the different
LEUKOPOIESIS LEARNING OBJECTIVES • To classify the different

... They may migrate to other organs for further differentiation Leukopoiesis  Is hormonally stimulated by two families of cytokines (hematopoietic factors) – interleukins and colony-stimulating factors (CSFs)  Interleukins are numbered (e.g., IL-1, IL-2), whereas CSFs are named for the WBCs they stim ...
Immune - lymphatic system
Immune - lymphatic system

... – surrounded by the reticular fibres • cords of Billroth ← lymphocytes, macrophages, reticular cells, ...


... • Antigen-induced regulatory CD4+ cells. • Develop from antigen stimulated Tlymhocytes in the environment of IL-10. • Tolerance of foreign antigens. • Very similar are „Th3 cells“. ...
Important Immune System Handout
Important Immune System Handout

... 8. This message travels to the nearest lymph node and seeks a Helper T-Cell that has the matching shape to the bacteria's antigen (now displayed on the outside of the dendritic cells. 9. Once a Helper T-cell match is found, the Helper T-Cell becomes activated and quickly duplicates many copies of it ...
School of Pathology and Laboratory Medicine [MS PowerPoint
School of Pathology and Laboratory Medicine [MS PowerPoint

... PhD Students: Constance Chew (UWA), Toni Wadley (Witts) ...
Indices of Tolerance
Indices of Tolerance

... The ELISpot bioassay assesses the specific immunological responses of a set of white cells from (CD4+ T cells) isolated from peripheral blood, induced against either Donor cells or 3rd party (unrelated) cells. Tolerant patients were found have the lowest ratio of donor: 3rd party responses compared ...
Immune System
Immune System

... major attack against a normally harmless substance For example, if you are allergic to pollen, your immune system treats the pollen as if it were a pathogen, causing nasal congestion and a runny nose ...
Khun Prasit Faipenkhong
Khun Prasit Faipenkhong

... Zhang Jianjun ...
Understanding the Immune System
Understanding the Immune System

... – T-Cells (Thymus derived) Natural Killer Cells (Innate Immunity)  CD4+ T-Cells (helper cells)  CD8+ T-Cells (cytotoxic cells) ...
Name: Date: Period: _____ The Immune Response: Web Analysis
Name: Date: Period: _____ The Immune Response: Web Analysis

... 3. can use vaccines to stimulate the immune system to produce antibodies 1. An immune deficiency disorder occurs when the immune system is missing certain cells 2. can be caused by infections or genetics 3. SCID (severe combined immunodeficiency disorder) occurs in children who lack B or T cells 4. ...
finals_study_guide_2007_hazbun
finals_study_guide_2007_hazbun

... 6. What do we mean by MHC restriction? 7. Why can a haplotype be present at a high rate in a population and how might it protect against a specific disease? 8. How is a haplotype spread and/or selected in a population? 9. What are the characteristics of balancing selection compared to driving select ...
Lymphatic system
Lymphatic system

...  release cytokines that stimulate other WBC’s  NK – granular lymphocytes, kill virus-infected cells  Protective proteins – complement and interferons  Form a membrane attack complex, warns non-infected cells of possible attack ...
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X-linked severe combined immunodeficiency

X-linked severe combined immunodeficiency (X-SCID) is an immunodeficiency disorder in which the body produces very few T cells and NK cells. In the absence of T cell help, B cells become defective. It is an x-linked recessive trait, stemming from a mutated (abnormal) version of the IL2-RG gene located at xq13.1 on the X-chromosome, which is shared between receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.
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