Hydroxychloroquine-Induced Retinal Toxicity
... 400 mg per day. Daily dosage is recommended not to exceed 400 mg. Risk for Toxicity Although it is not possible to predict which patients will develop retinal toxicity, high-risk characteristics include the following: • daily dose greater than 400 mg (or, in people of short stature, a daily dosage ...
... 400 mg per day. Daily dosage is recommended not to exceed 400 mg. Risk for Toxicity Although it is not possible to predict which patients will develop retinal toxicity, high-risk characteristics include the following: • daily dose greater than 400 mg (or, in people of short stature, a daily dosage ...
Demerol (meperidine hydrochloride)
... prior to labor has not been established relative to possible adverse effects on fetal development. When used as an obstetrical analgesic, DEMEROL crosses the placental barrier and can produce respiratory depression or psychophysiologic functions in the newborn; resuscitation may be required (see se ...
... prior to labor has not been established relative to possible adverse effects on fetal development. When used as an obstetrical analgesic, DEMEROL crosses the placental barrier and can produce respiratory depression or psychophysiologic functions in the newborn; resuscitation may be required (see se ...
Asthma Update
... • Rate of congenital malformations was no different from that of the general population (3.8 vs 3.5%)* • Based largely upon these findings, budesonide is currently the only inhaled corticosteroid with a pregnancy category B rating ...
... • Rate of congenital malformations was no different from that of the general population (3.8 vs 3.5%)* • Based largely upon these findings, budesonide is currently the only inhaled corticosteroid with a pregnancy category B rating ...
Physiological Role for COX-2
... Central sensitization, a possible pathogenic mechanism of the chronic pain associated with fibromyalgia, is mediated, in part, by the binding of excitatory amino acids (glutamate and aspartate) to the NMDA receptor. NMDA antagonists may inhibit or attenuate central sensitization [97] and potentiall ...
... Central sensitization, a possible pathogenic mechanism of the chronic pain associated with fibromyalgia, is mediated, in part, by the binding of excitatory amino acids (glutamate and aspartate) to the NMDA receptor. NMDA antagonists may inhibit or attenuate central sensitization [97] and potentiall ...
Exjade - Novartis Pharmaceuticals Corporation
... Fatal and nonfatal gastrointestinal bleeding, ulceration, and irritation: Risk may be greater in patients who are taking Exjade in combination with drugs that have known ulcerogenic or hemorrhagic potential. (5.3) Bone marrow suppression: Neutropenia, agranulocytosis, worsening anemia, and thrombocy ...
... Fatal and nonfatal gastrointestinal bleeding, ulceration, and irritation: Risk may be greater in patients who are taking Exjade in combination with drugs that have known ulcerogenic or hemorrhagic potential. (5.3) Bone marrow suppression: Neutropenia, agranulocytosis, worsening anemia, and thrombocy ...
Product Information: Tofacitinib (as citrate)
... Changes in total serum IgG, IgM, and IgA levels over 6-month tofacitinib dosing in patients with rheumatoid arthritis were small, not dose-dependent and similar to those seen on placebo. After treatment with tofacitinib in patients with rheumatoid arthritis, rapid decreases in serum C-reactive prote ...
... Changes in total serum IgG, IgM, and IgA levels over 6-month tofacitinib dosing in patients with rheumatoid arthritis were small, not dose-dependent and similar to those seen on placebo. After treatment with tofacitinib in patients with rheumatoid arthritis, rapid decreases in serum C-reactive prote ...
American BioSciences Inc. Nature & Science For Better ...
... summarized in Table Al. 1 in Appendix 1. In 3 studies the Avemar dose was 3000 mg/kg/day, equivalent to 2 10 g/day for a 70-pound human. In one study (Telekes et al. undated), a range of doses as high as 5000 mgikgday was used. The duration of administration of Avem‘ar was from 15 days (Telekes et a ...
... summarized in Table Al. 1 in Appendix 1. In 3 studies the Avemar dose was 3000 mg/kg/day, equivalent to 2 10 g/day for a 70-pound human. In one study (Telekes et al. undated), a range of doses as high as 5000 mgikgday was used. The duration of administration of Avem‘ar was from 15 days (Telekes et a ...
PharmII Block I Handouts
... B. The H2 antagonists are rapidly and well absorbed after oral administration (bioavailability 5090%). Peak plasma concentrations are reached in 1-3 hours, and the drugs have a t1/2 of 1-3 hours. C. Cross the blood-brain and placental barriers D. Elimination – Hepatic and renal metabolism. Bioavaila ...
... B. The H2 antagonists are rapidly and well absorbed after oral administration (bioavailability 5090%). Peak plasma concentrations are reached in 1-3 hours, and the drugs have a t1/2 of 1-3 hours. C. Cross the blood-brain and placental barriers D. Elimination – Hepatic and renal metabolism. Bioavaila ...
Dexmedetomidine Pediatric Critical Care Guideline
... Medication must be initiated by or on behalf of a pediatric critical care attending who has been involved primarily or in consultive manner in the care of the patient. Careful monitoring and possible dose reduction for patients with hepatic disease may be necessary due to hepatic metabolism via dire ...
... Medication must be initiated by or on behalf of a pediatric critical care attending who has been involved primarily or in consultive manner in the care of the patient. Careful monitoring and possible dose reduction for patients with hepatic disease may be necessary due to hepatic metabolism via dire ...
P97
... Background: We have observed an acute decrease in vancomycin serum levels to subtherapeutic range and failure to achieve anticipated therapeutic levels in babies after receiving theophylline and frusemide concurrently when usual dosage of vancomycin were given. An increase in glomerular filtration r ...
... Background: We have observed an acute decrease in vancomycin serum levels to subtherapeutic range and failure to achieve anticipated therapeutic levels in babies after receiving theophylline and frusemide concurrently when usual dosage of vancomycin were given. An increase in glomerular filtration r ...
LUCENTIS® Is the First Biologic FDA-Approved for the
... cataract. Proper aseptic injection technique should always be utilized when administering LUCENTIS. Patients should be monitored during the week following the injection to permit early treatment, should an infection occur. Increases in intraocular pressure (IOP) have been noted both pre-injection an ...
... cataract. Proper aseptic injection technique should always be utilized when administering LUCENTIS. Patients should be monitored during the week following the injection to permit early treatment, should an infection occur. Increases in intraocular pressure (IOP) have been noted both pre-injection an ...
Sublimaze® CII (fentanyl citrate injection) - Akorn
... however, the maximal analgesic and respiratory depressant effect may not be noted for several minutes. The usual duration of action of the analgesic effect is 30 to 60 minutes after a single intravenous dose of up to 100 mcg (0.1 mg) (2.0 mL). Following intramuscular administration, the onset of act ...
... however, the maximal analgesic and respiratory depressant effect may not be noted for several minutes. The usual duration of action of the analgesic effect is 30 to 60 minutes after a single intravenous dose of up to 100 mcg (0.1 mg) (2.0 mL). Following intramuscular administration, the onset of act ...
role of phenobarbitone as an antiepileptic drug in 21st century
... and incoordination. Death occurs due to depression of cardiorespiratory function. The severity of CNS depression is higher in drug naïve patients, compared to chronically treated patients for identical serum concentrations of phenobarbitone.4 Treatment consists of supportive care including mechanica ...
... and incoordination. Death occurs due to depression of cardiorespiratory function. The severity of CNS depression is higher in drug naïve patients, compared to chronically treated patients for identical serum concentrations of phenobarbitone.4 Treatment consists of supportive care including mechanica ...
Full Prescribing Information
... 5.1 Risk of Catheter-Related Bloodstream Infection Chronic intravenous infusions of Remodulin are delivered using an indwelling central venous catheter. This route is associated with the risk of blood stream infections (BSIs) and sepsis, which may be fatal. Therefore, continuous subcutaneous infusio ...
... 5.1 Risk of Catheter-Related Bloodstream Infection Chronic intravenous infusions of Remodulin are delivered using an indwelling central venous catheter. This route is associated with the risk of blood stream infections (BSIs) and sepsis, which may be fatal. Therefore, continuous subcutaneous infusio ...
Endophthalmitis prophylaxis
... Forty rabbits received bilateral 0.03 mL intracameral injections of Staphylococcus epidermidis (5 × 108 colony-forming units). Four groups of 10 rabbits had their eyes randomized to receive (1) 3 mg/mL gatifloxacin (Zymar) drops or shield in Zymar, (2) Zymar drops or shield in 10 mg/mL gatifloxacin ...
... Forty rabbits received bilateral 0.03 mL intracameral injections of Staphylococcus epidermidis (5 × 108 colony-forming units). Four groups of 10 rabbits had their eyes randomized to receive (1) 3 mg/mL gatifloxacin (Zymar) drops or shield in Zymar, (2) Zymar drops or shield in 10 mg/mL gatifloxacin ...
Hydrocortisone Lacticare-HC Lotion
... Therapy with Hydrocortisone (Lacticare-HC) should be gradually discontinued once control is achieved and an emollient continued as maintenance therapy. Rebound of pre-existing dermatoses can occur with abrupt discontinuation of topical corticosteroids. ...
... Therapy with Hydrocortisone (Lacticare-HC) should be gradually discontinued once control is achieved and an emollient continued as maintenance therapy. Rebound of pre-existing dermatoses can occur with abrupt discontinuation of topical corticosteroids. ...
PHYSICIANS` PRESCRIBING INFORMATION
... patient is permitted to take fluids and medication by mouth. If therapy has to be stopped temporarily, Dopicar may be restarted as soon as oral medication can be taken at the same daily dosage as before. Epidemiological studies have shown that patients with Parkinson's disease have a higher risk of ...
... patient is permitted to take fluids and medication by mouth. If therapy has to be stopped temporarily, Dopicar may be restarted as soon as oral medication can be taken at the same daily dosage as before. Epidemiological studies have shown that patients with Parkinson's disease have a higher risk of ...
dexamethasone sodium phosphate injection
... derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion. Administration of live virus vaccines, including smallpox, is contraindicated in individuals receiving immunosuppressive doses of cort ...
... derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion. Administration of live virus vaccines, including smallpox, is contraindicated in individuals receiving immunosuppressive doses of cort ...
Zantac - GSK Source
... other agents that increase gastric pH. Chronic use of H2-receptor antagonists with delavirdine is not recommended. Gefitinib: Gefitinib exposure was reduced by 44% with the coadministration of ranitidine and sodium bicarbonate (dosed to maintain gastric pH above 5.0). Use with caution. Glipizide: In ...
... other agents that increase gastric pH. Chronic use of H2-receptor antagonists with delavirdine is not recommended. Gefitinib: Gefitinib exposure was reduced by 44% with the coadministration of ranitidine and sodium bicarbonate (dosed to maintain gastric pH above 5.0). Use with caution. Glipizide: In ...
Prescribing Information
... CYP1A2 Substrates with Narrow Therapeutic Index (e.g., theophylline and tizanidine): Potential for increased exposure to CYP1A2 substrates; monitor drug concentrations of CYP1A2 substrates with narrow therapeutic index. (7.3) ...
... CYP1A2 Substrates with Narrow Therapeutic Index (e.g., theophylline and tizanidine): Potential for increased exposure to CYP1A2 substrates; monitor drug concentrations of CYP1A2 substrates with narrow therapeutic index. (7.3) ...
MDWISE MEDICAL NECESSITY CRITERIA
... The safety and effectiveness in pediatric patients below the age of 6 years have not been established. REFERENCES 1. National Asthma Education and Prevention Program. Expert panel report-3, 2007: Guidelines for the Diagnosis and Management of Asthma. Washington, DC: US Department of Health and Human ...
... The safety and effectiveness in pediatric patients below the age of 6 years have not been established. REFERENCES 1. National Asthma Education and Prevention Program. Expert panel report-3, 2007: Guidelines for the Diagnosis and Management of Asthma. Washington, DC: US Department of Health and Human ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... RESPIMAT has not been studied in the relief of acute symptoms and extra doses should not be used for that purpose. Acute symptoms should be treated with an inhaled short-acting beta2-agonist. When beginning STIOLTO RESPIMAT, patients who have been taking inhaled, short-acting beta2-agonists on a reg ...
... RESPIMAT has not been studied in the relief of acute symptoms and extra doses should not be used for that purpose. Acute symptoms should be treated with an inhaled short-acting beta2-agonist. When beginning STIOLTO RESPIMAT, patients who have been taking inhaled, short-acting beta2-agonists on a reg ...
VIEW PDF - Practical Dermatology
... absorption. Plasma levels of isotretinoin in the fasting state have been shown to be nearly 60 percent lower than levels in the fed state.3 Moreover, twice-daily dosing is a more effective regimen than once-daily dosing. In addition, trough levels of twice-daily dosing with isotretinoin actually exc ...
... absorption. Plasma levels of isotretinoin in the fasting state have been shown to be nearly 60 percent lower than levels in the fed state.3 Moreover, twice-daily dosing is a more effective regimen than once-daily dosing. In addition, trough levels of twice-daily dosing with isotretinoin actually exc ...
Brimonidine AFT
... and have revealed no evidence of impaired fertility or harm to the foetus due to BRIMONIDINE eye drops. Additionally, teratogenicity studies showed no adverse effects in rats or rabbits when oral doses were administered at approximately 333 and 24 times respectively, the human drug plasma concentrat ...
... and have revealed no evidence of impaired fertility or harm to the foetus due to BRIMONIDINE eye drops. Additionally, teratogenicity studies showed no adverse effects in rats or rabbits when oral doses were administered at approximately 333 and 24 times respectively, the human drug plasma concentrat ...
21 Pharmacology of Antiarrhythmic Agents
... the urine. Therapeutic serum levels range from 1.5–6.0 µg/mL. Lidocaine clearance is reduced by CHF, hepatic dysfunction, and concomitant treatment with cimetidine or beta-blockers. Clinical Uses. Lidocaine is useful in the control of ventricular arrhythmias. It is not useful for the treatment of su ...
... the urine. Therapeutic serum levels range from 1.5–6.0 µg/mL. Lidocaine clearance is reduced by CHF, hepatic dysfunction, and concomitant treatment with cimetidine or beta-blockers. Clinical Uses. Lidocaine is useful in the control of ventricular arrhythmias. It is not useful for the treatment of su ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.