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ambrisentan
ambrisentan

... (40 mg) were unaffected by multiple doses of ambrisentan (10 mg once daily). The effects of 12 days dosing with ambrisentan (10 mg once daily) on the pharmacokinetics of a single dose of oral contraceptive containing norethindrone 1 mg and ethinyl estradiol 35 micrograms were studied in healthy fema ...
Comparison of Nitrate Preparations
Comparison of Nitrate Preparations

... There are numerous nitrate products and formulations available on the market. Choosing the right nitrate product and the appropriate dosing regimen often causes confusion. Furthermore, clinicians are often not sure about product therapeutic equivalence. Nitrates are widely used in the management of ...
Ertapenem Once Daily Versus Piperacillin
Ertapenem Once Daily Versus Piperacillin

... CSSSI, complicated intra-abdominal infections, communityacquired pneumonia, complicated urinary tract infections, and acute pelvic infections. This structurally unique carbapenem is highly active in vitro against the bacteria typically associated with community-acquired infections, including methici ...
Superior rectus underaction following botulinum toxin injection to
Superior rectus underaction following botulinum toxin injection to

... may explain the reduced incidence of SR underaction in our patients. Ellis and Daniell encountered diplopia in 5 out of 21 patients when BTXA was injected transcutaneously, but the diplopia resolved in all cases.6 Our study shows that injecting BTXA (Dysport) to induce protective ptosis via a transc ...
Restoril™ (temazepam) Capsules USP Rx only DESCRIPTION
Restoril™ (temazepam) Capsules USP Rx only DESCRIPTION

... which are considered skeletal variants, in a second study at doses of 240 mg/kg or higher. In rabbits, occasional abnormalities such as exencephaly and fusion or asymmetry of ribs were reported without dose relationship. Although these abnormalities were not found in the concurrent control group, th ...
SUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS

... Gradual discontinuation of treatment reduces the risk of rebound insomnia (see section 4.4). Patients should be warned about the possibility of rebound insomnia after the therapy discontinuation in order to reduce the anxiety that may be caused by the possible ...
File - 911 Tactical Medicine
File - 911 Tactical Medicine

... worse while taking this medication. Epilepsy or history of seizures should not take these medications. ...
Prescribing Information
Prescribing Information

... The maximum recommended dose is 19.2 mcg/day (0.8 mcg/hr). Adjust the dose of intrathecal PRIALT according to the severity of pain, the patient’s response to therapy, and the occurrence of adverse reactions. 2.3 Instructions for Use with the Medtronic SynchroMed II Infusion System Refer to the manuf ...
Oral, Vision, Hearing
Oral, Vision, Hearing

... so marked that the general form of the tooth may be affected.  The major diagnostic sign of this classification is discrete or confluent pitting.  Brown stains are widespread and teeth often present a corrodedlike appearance. ...
Product Information – Australia  Atenolol. Chemical Name:
Product Information – Australia Atenolol. Chemical Name:

... hypertension in the third trimester. Administration of atenolol for longer periods to pregnant women in the management of mild to moderate hypertension has been associated with intrauterine growth retardation. The use of atenolol in women who are, or may become, pregnant requires that the anticipate ...
FORADIL CAPSULES FOR INHALATION (formoterol) 12 microgram
FORADIL CAPSULES FOR INHALATION (formoterol) 12 microgram

... who received placebo (0.3%), particularly in patients 5-12 years of age. Experience in adolescent and adult patients with asthma In two pivotal 12-week controlled trials conducted for US registration with combined enrollment of 1,095 patients 12 years of age and older, serious asthma exacerbations ( ...
phenytoin - DavisPlus
phenytoin - DavisPlus

... is missed from a once-a-day schedule, take as soon as possible and return to regular dosing schedule. If taking several doses a day, take missed dose as soon as possible within 4 hr of next scheduled dose; do not double doses. Consult health care professional if doses are missed for 2 consecutive da ...
Glucocorticosteroids
Glucocorticosteroids

... radiation, infection, and allergy. All regions of the adrenal cortex are destroyed in Addison’s disease. We will give steroids that will mimic the circadian rhythm. We give 2/3 dose in the morning and 1/3 in the evening. Adverse Effects Steroids can have adverse effects on carbohydrates, lipid, and ...
THE IDOLATRY OF THE SURROGATE
THE IDOLATRY OF THE SURROGATE

... Why have doctors become so invested in surrogate markers? The main reason is that the evidence base is built from trials that focus on the effect on surrogates. Since they respond sooner than outcomes that are important to patients, surrogates are better suited as end points in clinical trials that ...
DRUG CARDS A-list Paramedic rev0807 117KB Jan 14 2015
DRUG CARDS A-list Paramedic rev0807 117KB Jan 14 2015

...  Mechanism of Action; competes with opioids at opiate receptor sites  Indications; respiratory depression induced by opioids, coma of unknown origin (to rule out narcotic OD)  Contraindications; none in the emergency setting  Precautions; pregnancy, cardiovascular disease, opioid dependency, sei ...
Fever: beneficial and detrimental effects of antipyretics
Fever: beneficial and detrimental effects of antipyretics

... to be effective in this regard [24,25]. However, a recent large randomized trial in stroke patients demonstrated no differences in the poor outcomes (de®ned as severe disability, vegetative state, or death) between those treated with induced hypothermia and controls [26 . .]. A recent meta-analysis ...
Morphine Facts and Tips
Morphine Facts and Tips

... 440mg divided by 3=147 IM MS equivalents; 147mg/24 hr=6mg/hr. When should it be changed to another drug? When dose limiting side effects occur, changing to another agonist (e.g., Dilaudid, methadone, fentanyl) may improve analgesia and should be considered before progressing to a more invasive route ...
resonium a - product information
resonium a - product information

... In the event of clinically significant constipation, treatment with the resin should be discontinued until normal bowel habit is resumed. Magnesium containing laxatives should not be used (see Interactions with Other Medicines). With oral administration, care should be taken to avoid aspiration, whi ...
seizures - emergency
seizures - emergency

... severe illness, head injury, stroke, prolonged hypoxia, or other disorders. It is most important to prevent injury during the seizure by guiding the patient away from hard structures; do not tightly restrain. Ensure that the airway is open, but do not insert any object into the mouth. There is a goo ...
Effect  of  three different bronchodilators during  an
Effect of three different bronchodilators during an

... curve with this drug, the possibility that theophylline in higher serum concentrations could have induced a significantly higher bronchodilatation cannot be excluded. VozEH et al. [9] found a significant improvement in lung function with the use of high concentrations of theophylline in COPD during ...
IOPIDINE 0.5% (apraclonidine ophthalmic solution) 0.5% as base
IOPIDINE 0.5% (apraclonidine ophthalmic solution) 0.5% as base

... failure patients, structurally related clonidine undergoes a significant increase in half-life in patients with severe renal impairment. Close monitoring of cardiovascular parameters in patients with impaired renal function is advised if they are candidates for topical apraclonidine therapy. Close m ...
PredniSONE Tablets USP, 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and
PredniSONE Tablets USP, 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and

... immunosuppressive doses of corticosteroids. Killed or inactivated vaccines may be administered. However, the response to such vaccines may be diminished and cannot be predicted. Indicated immunization procedures may be undertaken in patients receiving nonimmunosuppressive doses of corticosteroids as ...
Spiriva Respimat [product monograph].
Spiriva Respimat [product monograph].

... RESPIMAT was 2,395 patient-years. In a 4-year, randomized, double-blind, placebo-controlled, multicenter clinical trial of tiotropium bromide inhalation powder (SPIRIVA HANDIHALER, the UPLIFT® study) in 5992 COPD patients a similar incidence rate of death had been observed between SPIRIVA HANDIHALE ...
FULL PRESCRIBING INFORMATION
FULL PRESCRIBING INFORMATION

... Adverse reactions in dose-finding, efficacy, and long-term clinical studies: The data described below reflect exposure to Amitiza 24 mcg twice daily in 1113 patients with chronic idiopathic constipation over 3- or 4-week, 6-month, and 12-month treatment periods; and from 316 patients receiving place ...
ZUCLOPENTHIXOL tab, drops , amp: Class: Typical antipsychotic
ZUCLOPENTHIXOL tab, drops , amp: Class: Typical antipsychotic

... There are no dosage adjustments provided in manufacturer's labeling; however, renal impairment is not likely to influence systemic exposure as the drug undergoes extensive hepatic metabolism and is primarily excreted in the feces. Hepatic Impairment: There are no dosage adjustments provided in manuf ...
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Ofloxacin



Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.
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