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The Unrecognised Revolution in Global Health
The Unrecognised Revolution in Global Health

... of the most deadly infectious diseases in the world.1 It is also highly contagious – a single TB patient with active disease can infect up to 15 people simply by coughing, sneezing or talking.3 Our front-line drugs and diagnostic tests for TB are out-dated and often ineffective, and drug-resistant f ...
Autoimmunity
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Document
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... Autoimmune disease occurs when an immune response attacks our own tissues. Like all adaptive immune responses, it is focused on specific antigens by T-cell receptors and B cell receptors. In contrast to infection, the antigens that these cells recognise are processed from proteins within the target ...
In thinking about vaccines, recall that there are two arms
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... • For most viruses, you are immune to reinfection by the same virus (e.g., chicken pox). • Immunization or vaccination: Process by which one is exposed to a live or inactivated virus, or to components of the virus, in order to establish a state of immunity. • Immunizations against smallpox introduce ...
Click here for some supplementary information
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... to be made available on www.researchinvestments.org ) International AIDS Vaccine Initiative Irish government Medical Research Council Miscellaneous National Blood Service NHS Other NIH Own account / local funding Professional body or society Scottish government funding UK government, non DH Unfunded ...
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Connecticut Department of Public Health
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... diagnosis and one use in treatment. Monoclonal antibodies are named so because they are the product of a single cloning of cells and are all exactly identical. Most immune reactions are polyclonal and often produce antibodies that are not specific enough to fight diseases when taken out and injected ...
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Vaccination



Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to a pathogen. Vaccines can prevent or ameliorate morbidity from infection. When a sufficiently large percentage of a population has been vaccinated, this results in herd immunity. The effectiveness of vaccination has been widely studied and verified; for example, the influenza vaccine, the HPV vaccine, and the chicken pox vaccine. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the worldwide eradication of smallpox and the restriction of diseases such as polio, measles, and tetanus from much of the world. The World Health Organization (WHO) reports that licensed vaccines are currently available to prevent or contribute to the prevention and control of twenty-five infections.The active agent of a vaccine may be intact but inactivated (non-infective) or attenuated (with reduced infectivity) forms of the causative pathogens, or purified components of the pathogen that have been found to be highly immunogenic (e.g., outer coat proteins of a virus). Toxoids are produced for immunization against toxin-based diseases, such as the modification of tetanospasmin toxin of tetanus to remove its toxic effect but retain its immunogenic effect.Smallpox was most likely the first disease people tried to prevent by inoculating themselves and was the first disease for which a vaccine was produced. The smallpox vaccine was discovered in 1796 by the British physician Edward Jenner, although at least six people had used the same principles years earlier. Louis Pasteur furthered the concept through his work in microbiology. The immunization was called vaccination because it was derived from a virus affecting cows (Latin: vacca—cow). Smallpox was a contagious and deadly disease, causing the deaths of 20–60% of infected adults and over 80% of infected children. When smallpox was finally eradicated in 1979, it had already killed an estimated 300–500 million people in the 20th century.In common speech, 'vaccination' and 'immunization' have a similar meaning. This distinguishes it from inoculation, which uses unweakened live pathogens, although in common usage either can refer to an immunization. Vaccination efforts have been met with some controversy on scientific, ethical, political, medical safety, and religious grounds. In rare cases, vaccinations can injure people and, in the United States, they may receive compensation for those injuries under the National Vaccine Injury Compensation Program. Early success and compulsion brought widespread acceptance, and mass vaccination campaigns have greatly reduced the incidence of many diseases in numerous geographic regions.
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