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Should I Enter a Clinical Trial? A Patient Reference
Should I Enter a Clinical Trial? A Patient Reference

... Chapter 1—Who Should Use This Guide?............................................................................................................1 How can this Guide help me? .............................................................................................................................. ...
P HO I HA
P HO I HA

... misbranded ." Therefore, because teaching a dosage unsupported by safety and efficacy the label would be a violation of the Federal Food, Drug and Cosmetic Act (FDCA), including the downward titration statement in the proposed IVAX label would be impermissible . However, omitting this downward titra ...
Skin - The Dermatologist
Skin - The Dermatologist

... have a significant impact on the results of treatment regardless of what medications are prescribed. As we further come to understand the relationships between epidermal barrier function and specific underlying skin diseases, it becomes more apparent that proper skin care not only impacts tolerabili ...
Abiraterone Acetate in Combination with Prednisone for the
Abiraterone Acetate in Combination with Prednisone for the

... endpoints were compared between treatment groups according to the Hochberg test procedure at an overall two-sided 0.05 level of significance. The intent-to-treat population of all randomized patients, regardless of the actual treatment received, was used for all efficacy analyses. The safety populat ...
A perspective on pediatric epilepsy clinical trials
A perspective on pediatric epilepsy clinical trials

... particular challenges, including correct diagnoses, comorbidities and interactions with developmental processes in the brain. While epilepsy is usually controlled with available medication, either as monotherapy or add-on anti-epileptic drug combinations, more than 30% of people with epilepsy do not ...
B (BLISTER)
B (BLISTER)

... A randomised controlled trial to compare the safety and effectiveness of doxycycline (200 mg/day) with prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid ...
(PSD) March 2016 PBAC Meeting - (Word 93KB)
(PSD) March 2016 PBAC Meeting - (Word 93KB)

... different from that of dabrafenib + trametinib, is tolerable and manageable. The submission concluded that it was therefore not necessary to include the cost of AEs in the cost-minimisation analysis or the financial estimates. This conclusion though is by assertion and is not supported by quantitati ...
American Academy of Clinical Neuropsychology (AACN) Practice
American Academy of Clinical Neuropsychology (AACN) Practice

... the examination process for clinical neuropsychology board certification candidates, with AACN being the membership organization for individuals who have been awarded board certification by ABCN. Inherent in this examination process are de facto and consensually accepted standards for training, know ...
Use of Lisdexamfetamine dimesylate in treatment of executive functioning
Use of Lisdexamfetamine dimesylate in treatment of executive functioning

... scores were less than 1.5 standard deviations above the standardized population mean (a t-score less than 65). Participants were also excluded if they had been treated with any psychostimulant within the prior 6-months. Women of childbearing potential were excluded if they did not test negative for ...
Genetic polymorphism and drug interactions: their
Genetic polymorphism and drug interactions: their

... – tests needed to prevent one case of toxicity vs cost ...
Clinical Care Options Hepatitis Annual Update 2009
Clinical Care Options Hepatitis Annual Update 2009

... attribution not be changed. Users are asked to honor this intent  These slides may not be published or posted online without permission from Clinical Care Options Disclaimer The materials published on the Clinical Care Options Web site reflect the views of the authors of the CCO material, not those ...
Review of Vasodilators in Acute Decompensated Heart Failure
Review of Vasodilators in Acute Decompensated Heart Failure

... Hg in the NTG group, 125 6 19 mm Hg in the group receiving only diuretics, and 125 6 18 mm Hg in the group receiving no diuretics; P 5 .001). Despite evidence of improved clinical outcomes with NTG therapy in hypertensive patients with ADHF, no large randomized double-blinded placebo-controlled tria ...
1 - VCU Massey Cancer Center - Virginia Commonwealth University
1 - VCU Massey Cancer Center - Virginia Commonwealth University

... may be useful in organizing this information. They may be used or deleted as appropriate. 1.2.1 Preclinical Data ...
Antibiotics for community acquired lower respiratory tract infections
Antibiotics for community acquired lower respiratory tract infections

... consensus. Trials that satisfied the inclusion criteria were reviewed and the following information recorded: study setting; year of study; source of funding; patient recruitment details (including number of eligible children); inclusion and exclusion criteria; randomisation and allocation concealme ...
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HEALTHCARE SECTOR SECONDARY RESEARCH SAMPLE REPORT

... eltrombopag, while maintaining platelet counts = 50,000/microL will be investigated. RAISE: Randomized, double-blind, placebo- Pts w/ platelet counts between controlled study, to evaluate efficacy, safety 50,000/uL and and tolerability of eltrombopag, initially administered as 50 mg oral tablets onc ...
Course Title - Stephen F. Austin State University
Course Title - Stephen F. Austin State University

... To learn more about using D2L, visit SFA ONLINE at http://sfaonline.sfasu.edu and https://d2l.sfasu.edu/ where you will find instructions and video tutorials. You are responsible for being able to utilize D2L. Clinical Experience: PURPOSE: The purpose of the N306 practicum is to provide a clinical p ...
Clinical application of the Society for Vascular
Clinical application of the Society for Vascular

... stratification to serve as a foundation for subsequent comparison of outcomes among centres, patient subgroups, and revascularisation procedures12. This new classification system is not intended or ...
Prior Elicitation in Bayesian Clinical Trial Design
Prior Elicitation in Bayesian Clinical Trial Design

... 1. Its first purpose is to treat the patients in the trial. 2. Its second purpose is to collect information that may be useful to evaluate existing treatments or develop new, better treatments to benefit future patients. Other, related purposes of clinical trials: 3. Generate data for research paper ...
1 - Robert H. Lurie Comprehensive Cancer Center
1 - Robert H. Lurie Comprehensive Cancer Center

... Please provide disease background information particularly relevant to your study, such as incidence, prognosis or current data corresponding to planned endpoints; be specific about the population being studied (e.g. relapsed/refractory disease or previously untreated or those possessing a particula ...
APAC
APAC

... Each entry into the patients medical records must be dated, timed, and have the attending health care workers signature, first initial and surname, and employee identifying number. ...
Long-acting Beta-Agonists with and without Inhaled Corticosteroids and Catastrophic Asthma Events
Long-acting Beta-Agonists with and without Inhaled Corticosteroids and Catastrophic Asthma Events

... meta-analysis, these data were considered to be 2 pooled trials of long-acting ␤-agonists, one without any concomitant corticosteroid use and one with background corticosteroid use in all patients. Trials were excluded for the following reasons: Two trials were not randomized, 2 trials were of asthm ...
Nepafenac - Therapeutic Goods Administration
Nepafenac - Therapeutic Goods Administration

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Phase 1 study to evaluate the feasibility and efficacy
Phase 1 study to evaluate the feasibility and efficacy

... transplantation has been considered the only curative treatment option for patients with CML. The dependence on age and donor type has limited the offer of stem cell transplantation to a minority of patients. The use of imatinib has been approved for the treatment of pretreated and de novo CML since ...
highlights of prescribing information
highlights of prescribing information

... Study 1 and Study 2, the recurrence rate at 12 months was 54% where recurrence was defined as the percentage of subjects with any identified AK lesion in the previously treated area who achieved complete clearance at Day 57. 14.2 Actinic Keratosis of the Trunk and Extremities In two double-blind, ve ...


... symptomatic men do not have bacterial prostatitis, for which the treatment and management is usually successful(2). Therefore, as noted by Krieger et al(3), the most common syndromes for men with chronic prostatitis are idiopathic (abacterial prostatitis). Depending on the status of the expressed pr ...
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Clinical trial

Clinical trials are experiments done in clinical research. Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial - their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.Depending on product type and development stage, investigators initially enroll volunteers and/or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single research center or multiple centers, in one country or in multiple countries. Clinical study design aims to ensure the scientific validity and reproducibility of the results.Trials can be quite costly, depending on a number of factors. The sponsor may be a governmental organization or a pharmaceutical, biotechnology or medical device company. Certain functions necessary to the trial, such as monitoring and lab work, may be managed by an outsourced partner, such as a contract research organization or a central laboratory.Only 10% of all drugs started in human clinical trials become an approved drug.
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