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Product Monograph
Product Monograph

... Animal reproduction studies have not been conducted with Hizentra. The safety of Hizentra for use in human pregnancy has not been established in controlled clinical trials. Hizentra should be given to pregnant women only if clearly needed. Continued treatment of the pregnant woman is important to en ...
Chemotherapy of advanced non-small
Chemotherapy of advanced non-small

... diagnosed with advanced, unresectable disease that remains incurable, while most patients who are treated with curative intent will eventually develop metastatic disease. Improvements in our understanding of the molecular basis of lung cancer have led to the development of targeted agents resulting ...
Platelet glycoprotein IIb/IIIa receptor blockade in coronary
Platelet glycoprotein IIb/IIIa receptor blockade in coronary

... pathway to platelet aggregation. Intravenous agents directed against this receptor include the chimeric monoclonal antibody fragment abciximab, the peptide inhibitor eptifibatide and nonpeptide mimetics tirofiban and lamifiban. Over 33,000 patients have been evaluated in 11 large-scale, placebo-cont ...
The Power of Expectation – Understanding the Placebo and Nocebo
The Power of Expectation – Understanding the Placebo and Nocebo

... even in surgery. The beliefs of patients about the drugs they receive substantially influence the amount of medication they need. This was shown by Benedetti et al. (2006) with Alzheimer disease patients who received a painful venipuncture. The authors used a design in which patients could receive l ...
DOI: 10.1161/CIRCULATIONAHA.108.839282 published online Jun
DOI: 10.1161/CIRCULATIONAHA.108.839282 published online Jun

... have occurred if 2 of the following 5 criteria were present: chest pain lasting longer than 30 minutes; substantial changes on ECG that were typical of acute myocardial infarction (an ST-segment elevation of 0.1 mV in at least 2 adjacent ECG leads or the new occurrence of a complete left bundle-bran ...
notable articles of 2016 - Johns Hopkins Bloomberg School of
notable articles of 2016 - Johns Hopkins Bloomberg School of

... Since this is a disease of older men, the study balanced the competing issues of aggressive treatment of a redolent disease with the reality that other factors may claim the life of the patient before he succumbs to prostate cancer. It provided solid landmarks for men wrestling with what to do when ...
LoNgER DuRAtIoN. gREAtER RoI.
LoNgER DuRAtIoN. gREAtER RoI.

... At physiological pH, tulathromycin (a weak base) is approximately 50 times more soluble in hydrophilic than hydrophobic media. This solubility profile is consistent with the extracellular pathogen activity typically associated with the macrolides.1 Markedly higher tulathromycin concentrations are ob ...
OCA013-10_Efficacy p
OCA013-10_Efficacy p

... Malaria is an important cause of morbidity and mortality and is considered a major public health problem in DRC, a high transmission country (≥1 per 1000 population)4. In 2011 DRC reported distributions of confirmed malaria cases of between 10 and ≥100 cases per 1000 population4;5. The disease accou ...
A Review of the Serotonin-Norepinephrine Reuptake Inhibitors
A Review of the Serotonin-Norepinephrine Reuptake Inhibitors

... Background: Depression is characterized by low mood, low self-esteem, and loss of interest or pleasure. Painful physical symptoms (PPS) associated with depression have a negative impact on the probability of remission. Because both norepinephrine and serotonin are involved with the central regulatio ...
(R)methadone versus racemic methadone: what is best for patient
(R)methadone versus racemic methadone: what is best for patient

... provide safer, more effective and integrated care. Methadone is a drug that confers significant medical risk, and the ability to assess that risk and provide the best treatment for individual patients is essential. This tenet will not be altered whether or not (R)-methadone is adopted in the United ...
Neonatal Long Line Insertion - Royal Cornwall Hospitals NHS Trust
Neonatal Long Line Insertion - Royal Cornwall Hospitals NHS Trust

... Saline until tip site confirmed by X-Ray (0.3ml contrast will be needed for Premicath lines, flushed with saline immediately after X-Ray taken) Longline position on X-Ray should be immediately reviewed by a senior medical staff member. Clear documentation in the medical notes of the line tip positio ...
PDF - Circulation: Heart Failure
PDF - Circulation: Heart Failure

... Several aspects of the pharmacology of loop diuretics may account in part for the observed variability in diuretic dosing for ADHF. Heart failure shifts the dose–response curve for loop diuretics downward and the right, necessitating a higher starting dose to achieve the same level of sodium excreti ...
Recurrent Herpes Simplex Labialis
Recurrent Herpes Simplex Labialis

... 14 days. Consequently, this type of lesion responds only to prophylactic therapy, if it responds at all.5 It has been suggested that classical lesions (those preceded by a prodrome) be monitored to understand their pattern of development.6 It is postulated that these lesions arise from dormant virus ...
A Double-Blind, Randomised, Placebo
A Double-Blind, Randomised, Placebo

... procedures were undertaken by a trained physician. The primary efficacy measures were continuous abstinence since the smoking discontinuation from day 5 to the end of week 8 and from day 5 to end of week 26. That was defined as no cigarettes at all and verified with exhaled CO level. Those patients ...
FOI 204-1314 document 1 - Therapeutic Goods Administration (TGA)
FOI 204-1314 document 1 - Therapeutic Goods Administration (TGA)

... human platelets. In vitro studies in animals also suggest that sertraline is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on noradrenaline and dopamine neuronal reuptake. In vitro studies have shown that sertraline has no significant affinity to adre ...
Allergy/Immunology Fellow Curriculum - URMC
Allergy/Immunology Fellow Curriculum - URMC

... Faculty evaluation based on clinical work and conferences. SUBSPECIALTY SPECIFIC GOALS The specific goals are derived from the Mission Statement and include: 1. Development of clinically competent allergists/clinical immunologists. 2. Development of allergists/clinical immunologists who are competen ...
Long-term  effects  of  budesonide  on ... clinical  asthma  severity  in  inhaled ...
Long-term effects of budesonide on ... clinical asthma severity in inhaled ...

... have similar topical potency to budesonide [12]. Subjects were required to be stable on their maintenance dose of beclomethasone dipropionate for at least 4 wks before randomization and they were also required not to have needed or taken prednisone or cromoglycate within two months of enrolment. Wom ...
CLINICAL STUDY PROTOCOL - Annals of the Rheumatic Diseases
CLINICAL STUDY PROTOCOL - Annals of the Rheumatic Diseases

... C-reactive protein (CRP) Be on disease modifying anti-rheumatic drugs (DMARD) treatment for RA for at least 6 months, with a stable dose for at least 6 weeks prior to screening visit (Visit 0) Have duration of morning stiffness of at least 45 minutes Have swollen joint count of 4 or more out of 28 H ...
Ravimid laste jaoks
Ravimid laste jaoks

... • 1937 – 107 people with streptococcal infection died (mainly children) ...
Lemon Balm - Gaia Herbs
Lemon Balm - Gaia Herbs

... essential oil content of the plant and that the top third of the leafy plant has the highest amount of volatile oil. 3 ...
Genvoya - Gilead
Genvoya - Gilead

... and HBV who discontinue GENVOYA should be closely monitored with both clinical and laboratory follow-up for at least several months after stopping treatment. If appropriate, initiation of anti-hepatitis B therapy may be warranted, especially in patients with advanced liver disease or cirrhosis, sinc ...
LEMON BALM Mary Bove, ND An Overview of its Versatility, Effectiveness, and Indications
LEMON BALM Mary Bove, ND An Overview of its Versatility, Effectiveness, and Indications

... essential oil content of the plant and that the top third of the leafy plant has the highest amount of volatile oil. 3 ...
Per protocol analysis of therapeutic efficacy of chloroquine for the
Per protocol analysis of therapeutic efficacy of chloroquine for the

... Methods: Present study is a one arm, 28 day follow up, hospital based prospective observational study including 150 children aged 1 to 12 years with smear positive isolated Plasmodium vivax infections. Chloroquine was administered at the standard dose of 25 mg base/kg body weight over three days. Re ...
Question A65 Funding
Question A65 Funding

... GTAC and MHRA Devices. The CV should be in summary form, with only information relevant to the current application. For example, it should give evidence of previous research in the same field of study, and other relevant experience and training. The length should be a maximum of 2 pages of A4. It is ...
(pews) user manual
(pews) user manual

...  Promotion of situation awareness in frontline healthcare staff as to how the patient is and what their immediate needs are  Support for the bedside nurse or the junior doctor to alert senior colleagues using standard communication and a clear escalation pathway  Recognition that the score from p ...
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Clinical trial

Clinical trials are experiments done in clinical research. Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial - their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.Depending on product type and development stage, investigators initially enroll volunteers and/or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single research center or multiple centers, in one country or in multiple countries. Clinical study design aims to ensure the scientific validity and reproducibility of the results.Trials can be quite costly, depending on a number of factors. The sponsor may be a governmental organization or a pharmaceutical, biotechnology or medical device company. Certain functions necessary to the trial, such as monitoring and lab work, may be managed by an outsourced partner, such as a contract research organization or a central laboratory.Only 10% of all drugs started in human clinical trials become an approved drug.
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