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... described in SPC. Unexpected include also side effects mentioned in SPC when these occur in higher frequencies then described. Most cases of unexpected ADRs are associated with medicines newly introduced on the market It has no sense to report expected adverse In clinical praxis it is usually not ea ...
controlled clinical trials in tuberculosis
controlled clinical trials in tuberculosis

... this is to eliminate selection bias by which is meant the conscious or subconscious selection of study procedures (type of patient, certain investigation) that depart from the criteria laid down by the protocol. A controlled trial involves the inclusion of an established (or placebo) treatment again ...
Sponsor vs. Investigator
Sponsor vs. Investigator

... (emergency research). (continued…) ...
The Impact of Psychosocial Needs of Adolescent and Young Adult
The Impact of Psychosocial Needs of Adolescent and Young Adult

... population of adolescents and young adults (AYAs) between the ages of 15 and 39, however, have not benefited from medical advancements to the extent of older and younger populations; five year survival rates of AYAs diagnosed with cancer have increased minimally between 1975 and 1997, despite having ...
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Paediatric Addendum on Weight Control in - EMA

... Trials should be randomised, double-blind, placebo-controlled trials. There should be a run-in phase, followed after randomisation by a blinded treatment phase and follow-up. Non-pharmacological interventions (lifestyle changes, dietary manipulation, physical activity etc.) should be standardised an ...
Guideline on Pulmonary Arterial Hypertension - EMA
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... The efficacy of the currently registered medications in the management of PAH is mainly based on showing improvement in exercise capacity. However, it is now recognized that the therapeutic goals have broadened. The identification of multiple pathways involved in the pathogenesis of PAH, indicate th ...
Dynamic Left Ventricular Outflow Tract Obstruction: Clinical and
Dynamic Left Ventricular Outflow Tract Obstruction: Clinical and

... Background: Dynamic left ventricular outflow tract obstruction (LVOTO) is increasingly recognized in critically ill patients and is a cause of significant morbidity and mortality. Objectives: To identify clinical risk predictors that may identify patient at high-risk of developing LVOTO based on the ...
U.S. Prescribing Information - Concordia International Corp.
U.S. Prescribing Information - Concordia International Corp.

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health matters - Sussex County
health matters - Sussex County

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ppt
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AGAH Workshop
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... important ICH guidelines and topics.  It does also mention some special circumstances which are safety-relevant, e.g.: - appropriate timing of particular studies, - how to deal with cases of pregnancy during a clinical trial, - criteria of subject selection which are subject to the clinical phase. ...
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... USE IN SPECIFIC POPULATIONS Pregnancy Pregnancy Category C: There are no adequate and well-controlled studies in pregnant women. It is unknown whether VASCEPA can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. VASCEPA should be used during pregnancy only ...
Medicine Rotation Clinician Guide YEAR 4 2017
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crc sabah newsletter - Clinical Research Centre
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... First and foremost, I would like to congratulate the editorial team for their success in publishing the third edition of CRC Sabah Newsletter. This latest edition marks another important milestone for CRC Sabah. It has been more than 5 years since the inception of CRC Sabah. Since then we have seen ...
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...  A national evidence-based clinical guideline as reference standard  A nationally agreed set of audit points with methodology  A data collection proforma This format will diminish the amount of work required to set up a local quality audit in any of the specified areas and will represent a packag ...
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... According to typical patient information leaflets used in clinical trials: “A placebo is a dummy treatment which looks like a genuine medicine but contains no active ingredient.” Placebos are designed to look—and ideally taste, smell, and feel—like the drug that is being tested so that participants ...
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Template PNT DM/FF002

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Full Prescribing Information
Full Prescribing Information

... The molecular formula is C 15 H 14 N 2 O 4 S and the molecular weight is 318.35 g/mol. Belinostat is a white to off-white powder. It is slightly soluble in distilled water (0.14 mg/mL) and polyethylene glycol 400 (about 1.5 mg/mL), and is freely soluble in ethanol (> 200 mg/mL). The pKa values are 7 ...
Therapy of Congestive Heart Failure in Dogs
Therapy of Congestive Heart Failure in Dogs

... Pimobendan for the treatment of congestive heart failure in dogs. Some of the above-mentioned investigations and data led to the licensing of Pimobendan for the therapy of canine CHF in the majority of European countries over last few years, an achievement that no other veterinary drug can claim so ...
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beatson west of scotland cancer centre

... as an 18 bed 5 day/week chemotherapy ward. There is also a large and busy Day Case Chemotherapy Unit comprising 36 treatment stations. The centre has its own out-patient department and a large aseptic facility for cytotoxic reconstitution. The unit has an accredited gene therapy aseptic facility. Up ...
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Clinical trial

Clinical trials are experiments done in clinical research. Such prospective biomedical or behavioral research studies on human participants are designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial - their approval does not mean that the therapy is 'safe' or effective, only that the trial may be conducted.Depending on product type and development stage, investigators initially enroll volunteers and/or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary in size and cost, and they can involve a single research center or multiple centers, in one country or in multiple countries. Clinical study design aims to ensure the scientific validity and reproducibility of the results.Trials can be quite costly, depending on a number of factors. The sponsor may be a governmental organization or a pharmaceutical, biotechnology or medical device company. Certain functions necessary to the trial, such as monitoring and lab work, may be managed by an outsourced partner, such as a contract research organization or a central laboratory.Only 10% of all drugs started in human clinical trials become an approved drug.
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