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5 6 4  ‘00  OCT pz 3
5 6 4 ‘00 OCT pz 3

... Selegiline is also not a dietary ingredient under the definition of a dietary supplement in the FD&C Act. Under 2 1 U.S.C. 321(ff)( l), a dietary supplement is defined, in part, as a product that contains one or more dietary ingredients that are a “vitamin,” a “mineral,” an “amino acid,” and “herb o ...
Drug Design, Testing, Manufacturing, and Marketing
Drug Design, Testing, Manufacturing, and Marketing

... Excretion of drug e. want ads in classifieds of large cities recruiting volunteers f. informed consent mandatory g. volunteers monitored and given medical examinations 2. Phase II: Drug given to experimental patients with disease intended for eventual therapy to determine therapeutic effect 3. Phase ...
Revised section Chapter Page  Heading / subheading
Revised section Chapter Page Heading / subheading

... physician before taking fexofenadine. Fexofenadine should not be taken with fruit juices and aluminum or magnesium antacids because the absorption from the gastrointestinal track may be impaired, resulting in lower circulating drug concentrations. Recommended doses: Adults and children over 12 years ...
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... One MCQ phase test (40%) and an end of module MCQ exam (60%). The pass mark for each component is 50%. ...
Introduction - Indian Pharmacopoeia Commission
Introduction - Indian Pharmacopoeia Commission

DEPARTMENT OF COMMERCIAL TAXES, KERALA
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... regarding Senquel – AD 200 ml, 2013-14/001/WNF/00136 dtd.21-052013 regarding Clohex Plus 150 ml and 2013-14/001/WNF/00185 dtd.06-06-2013 relating to sale of Clohex 150 ml to M/s.Dr.Reddy’s Lab Ltd., Andhra Pradesh showing the above goods were cleared under Central Excise Tariff 3003.39.00. 9) The ab ...
Basic Biopharmaceutics
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... • One of the primary factors affecting oral drug absorption is the gastric emptying time. – This the time that the drug remains in the stomach before it is emptied into the small intestine – Most absorption occurs in the small intestine. – Some factors increase the gastric emptying time, but most sl ...
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Slide 1

... - mandatory registry for doctors who Rx; Contra-indication for psychoactive drug cocktails— --at least warning that polypharmacy has not been tested for safety, is therefore, experimental; Limit promotion: no advertising of drugs linked to violent or psychotic behavior; Require physicians to provide ...
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comments - Association of National Advertisers

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4th Quarter 2011 - University Hospital

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... for the following approvedindication: “traditionally used for improving energy,reduce body fatigue and enhanceoverall performance”.You assertin your notification, but without supporting documentation,that over “20 million capsulesof E.L. Jack Capsules have been sold in Asia since 1997and that thereh ...
業務核心
業務核心

Phenylpropanolamine (PPA) in medicinal products It has been
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... desirable from both economic and compliance point of view. These drugs have the capacity to improve the quality of patient life substantially. α- glucosidase inhibitors are oral anti-diabetic drugs. These drugs are competitive inhibitors of the intestinal α- glucosidases and reduce post meal excursi ...
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1776 Federal Register

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Biosimilar

A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product which is a copy of an original product that is manufactured by a different company. Biosimilars are officially approved versions of original ""innovator"" products, and can be manufactured when the original product's patent expires. Reference to the innovator product is an integral component of the approval.Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and may be quite sensitive to changes in manufacturing processes. Follow-on manufacturers do not have access to the originator's molecular clone and original cell bank, nor to the exact fermentation and purification process, nor to the active drug substance. They do have access to the commercialized innovator product.Drug related authorities such as European Medicines Agency (EMA), Food and Drug Administration (FDA), and Health Canada hold their own guidance on requirements for demonstration of the similar nature of two biological products in terms of safety and efficacy. According to them, analytical studies that demonstrate that the biological product is highly similar to the reference product notwithstanding minor differences in clinically inactive components; animal studies (including the assessment of toxicity); and a clinical study or studies (including the assessment of immunogenicity and pharmacokinetics or pharmacodynamics) that are sufficient to demonstrate safety, purity, and potency in one or more appropriate conditions of use for which the reference product is licensed and intended to be used and for which licensure is sought for the biological product.In case of a monoclonal antibody-containing medicinal product, such as Remsima, extensive physicochemical and biological characterization for it and its reference product Remicade was conducted in order to demonstrate their highly similar properties. Consequently, EMA have granted a marketing authorisation for only a few numbers of biosimilars since 2006 including a monoclonal antibody which is recently approved. Meanwhile, on March 6, 2015, the FDA approved the United States's first biosimilar product, the biosimilar filgrastim Zarxio.
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