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View SPC - Veterinary Medicines Directorate
View SPC - Veterinary Medicines Directorate

... viruses, protozoa, cysts and spores. Iodine is used as a disinfectant generally as a 2% or 2.5% solution. Its activity is reduced in the presence of organic matter, though not to the same extent as with other halogen disinfectants. A solution of iodine may be applied to small wounds or abrasions as ...
MedDRA Use at FDA
MedDRA Use at FDA

02. Factors modifying drug actions
02. Factors modifying drug actions

... propranolol, hemolytic anemia due to some oxidizing agents (primaquine, sulphonamides) ...
Highlights of Products Added via Special Authorization (SA
Highlights of Products Added via Special Authorization (SA

Chapter 1 - Drugs and Agents - Factors Affecting their Action
Chapter 1 - Drugs and Agents - Factors Affecting their Action

... Study of how drugs may best be used in the treatment of illnesses  Study of which drug would be most appropriate or least appropriate to use for a specific disease; what dose would be required; etc. ...
Antibiotic Use in Food Animals: FDA’s Current Activities Issue
Antibiotic Use in Food Animals: FDA’s Current Activities Issue

... FDA’s Efforts to Limit Animal Antibiotic Use The FDA Center for Veterinary Medicine (CVM) oversees the agency’s efforts to assure the safety and effectiveness of animal drugs, as required under Section 512 of the Federal Food, Drug, and Cosmetic Act (FFDCA, 21 U.S.C. 360b). CVM issues guidance docum ...
WORKSHEET: Human Research Determination (HRP-310)
WORKSHEET: Human Research Determination (HRP-310)

New Drug Application (NDA) Checklist
New Drug Application (NDA) Checklist

... quality and purity. The section must include the following information: (i) physical and chemical characteristics; (ii) stability; (iii) name and address of the manufacturer; (iv) manufacturer of the drug substance; (v) process controls; (vi) drug substance controls; (vii) solid-state drug substance ...
An overview of second  generation drugs  for photodynamic
An overview of second generation drugs for photodynamic

... At this early stage in the phase I clinical trials BPD-MA meets all of our preclinical expectations and we shall begin our phase II studies shortly. What can we expect for third generation drugs? In order to improve on any of the new compounds currently under clinical or preclinical studies for PDT ...
L1: Intro to Pharm- Objectives Describe what is meant by a drug`s
L1: Intro to Pharm- Objectives Describe what is meant by a drug`s

Pharmacokinetics
Pharmacokinetics

... the drug during the first few minutes after absorption. ...
INTRODUCTION TO PHARMACOLOGY
INTRODUCTION TO PHARMACOLOGY

Mechanisms of common and important adverse drug reactions
Mechanisms of common and important adverse drug reactions

... Mechanisms of common and important adverse drug reactions Jack W. Strandhoy, Ph.D. ...
this document in Microsoft Word format
this document in Microsoft Word format

... Over the past few years, a number of companies have been marketing potassium iodate for radiation protection in place of potassium iodide. Though the names are similar, the products are very different, and the US Food and Drug Administration has expressed serious concerns about the safety and effect ...
Microsoft Word format
Microsoft Word format

... CDER is also responsible for monitoring all human drugs and therapeutic biologics once they are on the market, and for taking action, if necessary, to remove products which may not be manufactured properly or may cause harm to the American people. This is no small task, given the thousands of appro ...
FDA CDRH Organizational Structure & Overview
FDA CDRH Organizational Structure & Overview

... section 201(h) of the Federal Food Drug & Cosmetic (FD&C) Act, it will be regulated by the FDA as a medical device. ...
Inhaled insulin is approved in Europe and United States
Inhaled insulin is approved in Europe and United States

... Seymour said reversal of decreases in FEV1 among patients with type 1 diabetes was "not convincing" and that it was unknown whether the decreased function would be reversible after longer periods of use. Exubera's label instructs patients to have pulmonary function tests before starting it. Paul Woo ...
III. Non-clinical aspects
III. Non-clinical aspects

... TSE risk is minimised in line with the Public Statement EMEA/CPMP/571/02. Pharmaceutical development Pharmaceutical development has been appropriately described. The formulation was intended to be a film-coated tablet with an immediate drug release similar to that of the innovator product. To demons ...
Botanix Pharmaceutical Investor Factsheet
Botanix Pharmaceutical Investor Factsheet

... pharmaceutical companies for the treatment of epilepsy, pain, arthritis and schizophrenia amongst other indications, but Botanix plans to be the first company to develop synthetic cannabidiol for skin diseases. Cannabidiol has been shown in pre-clinical studies to have a unique mechanism of action i ...
Zordera - ONdrugDelivery
Zordera - ONdrugDelivery

... to the back of the eye. Zordera, Inc, is the company set up to take the device through commercial development. An increasing number of biologics and the emergence of biosimilars have focused attention on the development of advanced drug delivery technologies. This industry is expected to reach US$51 ...
Teacher notes and student sheets
Teacher notes and student sheets

... treatment it is important to take precautions to prevent this. In a ‘blind’ trial, each individual does not know if he/she is in the treatment sample or the control sample. The trial is ‘double blind’ if the person who measures the outcomes also does not know this. Bl To assess the outcome of a tria ...
Mutual Recognition Procedure
Mutual Recognition Procedure

... receptors in the brain. The drug is used in the treatment of schizophrenia and acute manic disorders associated with bipolar disease. Quetiapine improves both psychotic symptoms and cognitive functions in schizophrenia. Similarly to the other substances used in these indications, exact mechanism of ...
Consumer Updates > Antibacterial Soap? You Can Skip It -
Consumer Updates > Antibacterial Soap? You Can Skip It -

... (FDA), there isn’t enough science to show that over-thecounter (OTC) antibacterial soaps are better at preventing illness than washing with plain soap and water. To date, the benefits of using antibacterial hand soap haven’t been proven. In addition, the wide use of these products over a long time h ...
Regulation documentation requirements
Regulation documentation requirements

... if two products differ in their release controlling excipients or mechanism but show similar in vitro dissolution profiles these products can be considered belonging to same category of pharmaceutical form and are considered essentially similar after showing bioequivalence if the products differ in ...
I ) NSTRUCTIONS FOR FILLING OUT FORM FDA 1571 – INVESTIGATIONAL
I ) NSTRUCTIONS FOR FILLING OUT FORM FDA 1571 – INVESTIGATIONAL

... the sponsor of a clinical investigation from continuing the investigation if FDA determines that the investigation is intended to support a biosimilar biological product application and the sponsor has failed to pay any required initial biosimilar biological product development (BPD) fee, annual BP ...
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Biosimilar

A biosimilar (also known as follow-on biologic or subsequent entry biologic) is a biologic medical product which is a copy of an original product that is manufactured by a different company. Biosimilars are officially approved versions of original ""innovator"" products, and can be manufactured when the original product's patent expires. Reference to the innovator product is an integral component of the approval.Unlike the more common small-molecule drugs, biologics generally exhibit high molecular complexity, and may be quite sensitive to changes in manufacturing processes. Follow-on manufacturers do not have access to the originator's molecular clone and original cell bank, nor to the exact fermentation and purification process, nor to the active drug substance. They do have access to the commercialized innovator product.Drug related authorities such as European Medicines Agency (EMA), Food and Drug Administration (FDA), and Health Canada hold their own guidance on requirements for demonstration of the similar nature of two biological products in terms of safety and efficacy. According to them, analytical studies that demonstrate that the biological product is highly similar to the reference product notwithstanding minor differences in clinically inactive components; animal studies (including the assessment of toxicity); and a clinical study or studies (including the assessment of immunogenicity and pharmacokinetics or pharmacodynamics) that are sufficient to demonstrate safety, purity, and potency in one or more appropriate conditions of use for which the reference product is licensed and intended to be used and for which licensure is sought for the biological product.In case of a monoclonal antibody-containing medicinal product, such as Remsima, extensive physicochemical and biological characterization for it and its reference product Remicade was conducted in order to demonstrate their highly similar properties. Consequently, EMA have granted a marketing authorisation for only a few numbers of biosimilars since 2006 including a monoclonal antibody which is recently approved. Meanwhile, on March 6, 2015, the FDA approved the United States's first biosimilar product, the biosimilar filgrastim Zarxio.
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