Lecture Resource ()
... Many drugs exert their physiological effects by binding to a specific cellular binding site called a receptor Excess histamine in the body causes the symptoms associated with the common cold and allergic responses ...
... Many drugs exert their physiological effects by binding to a specific cellular binding site called a receptor Excess histamine in the body causes the symptoms associated with the common cold and allergic responses ...
antianginal drugs
... 1) the difference of arteriovenous oxygen pressure: The heart’s oxygen needs are relatively high, and it extracts approximately 70-90% of the available oxygen even under conditions of no stress. 2) coronary blood flow: Coronary blood flow is directly related to the perfusion pressure (aortic diastol ...
... 1) the difference of arteriovenous oxygen pressure: The heart’s oxygen needs are relatively high, and it extracts approximately 70-90% of the available oxygen even under conditions of no stress. 2) coronary blood flow: Coronary blood flow is directly related to the perfusion pressure (aortic diastol ...
Noradrenergic Transmission
... Pseudoephedrine(stereoisomer of ephedrine) used orally for the relief of nasal congestion. Less potent than ephedrine in producing tachycardia, hypertension, C.N.S. stimulation. Used in the treatment of stress incontinence. ...
... Pseudoephedrine(stereoisomer of ephedrine) used orally for the relief of nasal congestion. Less potent than ephedrine in producing tachycardia, hypertension, C.N.S. stimulation. Used in the treatment of stress incontinence. ...
Hypertension
... Does not relax venous smooth muscle Compensatory reflex increase in sympathetic outflow Increase in HR, cardiac output, plasma renin activity and fluid retention Selective decrease in vascular resistance in coronary, cerebral and renal vascular beds Postural hypotension- uncommon because it doe ...
... Does not relax venous smooth muscle Compensatory reflex increase in sympathetic outflow Increase in HR, cardiac output, plasma renin activity and fluid retention Selective decrease in vascular resistance in coronary, cerebral and renal vascular beds Postural hypotension- uncommon because it doe ...
1-alpha adrenergic blockers 2017-03-15 05:542.2 MB
... 1) Vasodilatation of blood vessels (α1 block). 2) Decrease peripheral vascular resistance 3) Postural hypotension. Increase cardiac output (α2 block). 4) Reflex tachycardia. 5) Increase in GIT motility and secretions Reflex tachycardia occurs by two mechanisms: Stimulation of *baroreceptor reflex t ...
... 1) Vasodilatation of blood vessels (α1 block). 2) Decrease peripheral vascular resistance 3) Postural hypotension. Increase cardiac output (α2 block). 4) Reflex tachycardia. 5) Increase in GIT motility and secretions Reflex tachycardia occurs by two mechanisms: Stimulation of *baroreceptor reflex t ...
GABA Recognition Site
... o Reduce the sedative/hypnotic response thresholds to baclofen without displaying effects themselves o When administered alone they display anxiolytic, but not antidepressant, effects in laboratory animals without causing sedation, muscle relaxation or cognitive dysfunction ...
... o Reduce the sedative/hypnotic response thresholds to baclofen without displaying effects themselves o When administered alone they display anxiolytic, but not antidepressant, effects in laboratory animals without causing sedation, muscle relaxation or cognitive dysfunction ...
SMU-DDE-Assignments-Scheme of Evaluation PROGRAM Bachelor
... The actions of the drug on the body are termed as pharmacodynamics. The effect of a drug present at the site of action is determined by that drug’s binding with a receptor. However, at the molecular level, drug binding is only the first among a complex set of events. Types of drug – receptor interac ...
... The actions of the drug on the body are termed as pharmacodynamics. The effect of a drug present at the site of action is determined by that drug’s binding with a receptor. However, at the molecular level, drug binding is only the first among a complex set of events. Types of drug – receptor interac ...
PHARMACOTHERAPY OF HYPERTENSION
... Less effective in elderly patients Side effects: Bradycardia, cause rebound hypertension on sudden withdrawal Fatigue sleep disturbances and depression Propranolol mask the hypoglycemic symptoms produced by insulin and oral hypoglycemic ...
... Less effective in elderly patients Side effects: Bradycardia, cause rebound hypertension on sudden withdrawal Fatigue sleep disturbances and depression Propranolol mask the hypoglycemic symptoms produced by insulin and oral hypoglycemic ...
Review: lower dose combination antihypertensive therapy is
... findings aggregated in the review treat the disease (and the patients presenting with high BP) as homogeneous. Individual patients still need to be carefully assessed for other risk factors and the presence of comorbid conditions (eg, age, diabetes, kidney dysfunction, depression, and nonadherence) ...
... findings aggregated in the review treat the disease (and the patients presenting with high BP) as homogeneous. Individual patients still need to be carefully assessed for other risk factors and the presence of comorbid conditions (eg, age, diabetes, kidney dysfunction, depression, and nonadherence) ...
document
... occurring substance derived from plants. Its principal active ingredient is ephedrine, which when chemically synthesized is regulated as a drug. In recent years ephedra products have been extensively promoted to aid weight loss, enhance sports performance, and increase energy. But FDA has determined ...
... occurring substance derived from plants. Its principal active ingredient is ephedrine, which when chemically synthesized is regulated as a drug. In recent years ephedra products have been extensively promoted to aid weight loss, enhance sports performance, and increase energy. But FDA has determined ...
Antihypertensive-Drugs.15.Mar.2011
... tachycardia) Inhibition of aldosterone secretion contributes to the antihypertensive effects of ACE-I Influence on the arteriolar and left ventricular remodelling that are believed to be important in the pathogenesis of human essential hypertension and post-infarction state ...
... tachycardia) Inhibition of aldosterone secretion contributes to the antihypertensive effects of ACE-I Influence on the arteriolar and left ventricular remodelling that are believed to be important in the pathogenesis of human essential hypertension and post-infarction state ...
AZ compound details for MRC Asset Sharing Sept 2016
... mg for 7 days. Adverse events were CNS in nature, and included dizziness, feeling of relaxation, euphoric mood, somnolence, and headache. These were transient, mild, and related to peak plasma concentrations. In patients dosed for up to 28 days, AZD7325 was generally well tolerated with the most fre ...
... mg for 7 days. Adverse events were CNS in nature, and included dizziness, feeling of relaxation, euphoric mood, somnolence, and headache. These were transient, mild, and related to peak plasma concentrations. In patients dosed for up to 28 days, AZD7325 was generally well tolerated with the most fre ...
All of the following mechanism of action correctly match a drug
... 20. Which of the following hypertensive patients is most suited for primary therapy with hydrochlorothiazide? A. patients with gout B. patients with hyperlipidemia C. young hypertensive patients with rapid resting heart rate D. patients with impaired renal function E. elderly patients 21. The approp ...
... 20. Which of the following hypertensive patients is most suited for primary therapy with hydrochlorothiazide? A. patients with gout B. patients with hyperlipidemia C. young hypertensive patients with rapid resting heart rate D. patients with impaired renal function E. elderly patients 21. The approp ...
Slajd 1
... I generation: non-selective BBs II generation: cardioselective BBs III generation: beta-blockers (non-selective or cardioselectve BBs) with vasodilator activity: carvedilol, celiprolol, nebivolol ...
... I generation: non-selective BBs II generation: cardioselective BBs III generation: beta-blockers (non-selective or cardioselectve BBs) with vasodilator activity: carvedilol, celiprolol, nebivolol ...
Drug development
... Manipulate duration/profile: e.g. sustained release Bioequivalence Bioavailability Ease of use ...
... Manipulate duration/profile: e.g. sustained release Bioequivalence Bioavailability Ease of use ...
Neurotransmitter Receptors - VCC Library
... 4. A new diet drug has come on the market that claims to have fewer side effects than the previous drug from the same receptor family. Which receptor would the new drug likely target? The old drug? ...
... 4. A new diet drug has come on the market that claims to have fewer side effects than the previous drug from the same receptor family. Which receptor would the new drug likely target? The old drug? ...
Pritor® 40(80) mg and Co-Pritor® 40(80/12.5 mg)
... Several controlled studies have demonstrated that the fixeddose combination of telmisartan/hydrochlorothiazide is superior in lowering blood pressure than either telmisartan or hydrochlorothiazide alone. Recent data show that telmisartan 80 mg controls the early morning blood pressure surge more eff ...
... Several controlled studies have demonstrated that the fixeddose combination of telmisartan/hydrochlorothiazide is superior in lowering blood pressure than either telmisartan or hydrochlorothiazide alone. Recent data show that telmisartan 80 mg controls the early morning blood pressure surge more eff ...
What Rx is he taking?
... • Duloxetine (Cymbalta) – also used in MDD and diabetic neuropathic pain • Modafinil (Lyrica) – used for sleep disorders and many other reasons • Savella (milnacipran) – an antidepressant approved only for ...
... • Duloxetine (Cymbalta) – also used in MDD and diabetic neuropathic pain • Modafinil (Lyrica) – used for sleep disorders and many other reasons • Savella (milnacipran) – an antidepressant approved only for ...
Hit Parade -- EvidenceUpdates
... adults with mild hypertension (systolic blood pressure (BP) 140-159 mmHg and/or diastolic BP 90-99 mmHg) and without cardiovascular disease. SEARCH METHODS: We searched CENTRAL (2011, Issue 1), MEDLINE (1948 to May 2011), EMBASE (1980 to May 2011) and reference lists of articles. The Cochrane Databa ...
... adults with mild hypertension (systolic blood pressure (BP) 140-159 mmHg and/or diastolic BP 90-99 mmHg) and without cardiovascular disease. SEARCH METHODS: We searched CENTRAL (2011, Issue 1), MEDLINE (1948 to May 2011), EMBASE (1980 to May 2011) and reference lists of articles. The Cochrane Databa ...
to file - Planet Ross 2K2
... disease; frost bite; benign prostatic hypertrophy, heart failure ( preload/afterload) ...
... disease; frost bite; benign prostatic hypertrophy, heart failure ( preload/afterload) ...
Potent Direct Vasodilators
... Fall in total peripheral resistance and arterial pressure results in reflex cardio stimulation with frequent tachycardia and palpitation unless cardiac reflex responses are offset by concomitant beta-blockade. Sodium retention requires co-treatment with diuretic in most. A loop diuretic, sometimes a ...
... Fall in total peripheral resistance and arterial pressure results in reflex cardio stimulation with frequent tachycardia and palpitation unless cardiac reflex responses are offset by concomitant beta-blockade. Sodium retention requires co-treatment with diuretic in most. A loop diuretic, sometimes a ...
HYPERTENSION ABC & Update
... • Start with LOW DOSE & gradually increase it Post-MI & acute MI patients (including relatively contraindicated ones) have prolonged survival & reduced re-infarction High-Risk CHD: HTN patients with chronic angina or acute CHD (non-ST segment elevation MI & unstable angina) may proceed to fatal ...
... • Start with LOW DOSE & gradually increase it Post-MI & acute MI patients (including relatively contraindicated ones) have prolonged survival & reduced re-infarction High-Risk CHD: HTN patients with chronic angina or acute CHD (non-ST segment elevation MI & unstable angina) may proceed to fatal ...
The Drug Discovery Process
... Develop an assay to evaluate activity of compounds on the target - in vitro (e.g. enzyme assay) - in vivo (animal model or pharmacodynamic assay) ...
... Develop an assay to evaluate activity of compounds on the target - in vitro (e.g. enzyme assay) - in vivo (animal model or pharmacodynamic assay) ...
Final + Answers
... prostaglandin synthesis. Prostaglandins sensitize pain receptors; therefore, NSAIDs have an indirect analgesic effect by ‘desensitizing’ pain receptors. Opiods are opiate receptor agonists. Opioid analgesia is mediated through changes in the perception of pain at the spinal cord and higher levels in ...
... prostaglandin synthesis. Prostaglandins sensitize pain receptors; therefore, NSAIDs have an indirect analgesic effect by ‘desensitizing’ pain receptors. Opiods are opiate receptor agonists. Opioid analgesia is mediated through changes in the perception of pain at the spinal cord and higher levels in ...