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... • Synthetic: Isoproterenol, dobutamine • Structure: catechol moiety, ethylamine side chain • Inactivation: COMT, MAO; found in the gut, liver and other tissues • Low oral bioavailability, short plasma half-lives • Must be administered parenterally for systemic actions; Anaphylactic shock ...
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Pharmacology MCQs

... c. phentolamine increases spontaneous contraction. d. propranolol has significant action on spontaneous contraction. 78. Plasma T1/2 of a drug: a. is the same as biological T1/2. b. is the time required for concentration of drug in plasma to be reduced by 1/2. c. is usually lengthened if biologicall ...
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Discovery and development of beta-blockers

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