Using Propensity Scores To Adjust For Treatment Selection Bias
... Currently taking less medications, Poorer medication use behavior ...
... Currently taking less medications, Poorer medication use behavior ...
spc-doc_PL 20416-0081 - Medicines and Healthcare products
... The risk-benefit of haloperidol treatment should be fully assessed before treatment is commenced and patients with risk factors for ventricular arrhythmias such as cardiac disease, family history of sudden death and/or QT prolongation; uncorrected electrolyte disturbances, subarachnoid haemorrhage, ...
... The risk-benefit of haloperidol treatment should be fully assessed before treatment is commenced and patients with risk factors for ventricular arrhythmias such as cardiac disease, family history of sudden death and/or QT prolongation; uncorrected electrolyte disturbances, subarachnoid haemorrhage, ...
Drug-Coated Balloons for Coronary Artery Disease
... this study, 52 patients with coronary in-stent restenosis were randomized to conventional percutaneous transluminal coronary angioplasty or a 3-mg/mm2 iopromidepaclitaxel–coated balloon (Paccocath). At 6 months, angiographic follow-up demonstrated a significant difference in the primary endpoint of ...
... this study, 52 patients with coronary in-stent restenosis were randomized to conventional percutaneous transluminal coronary angioplasty or a 3-mg/mm2 iopromidepaclitaxel–coated balloon (Paccocath). At 6 months, angiographic follow-up demonstrated a significant difference in the primary endpoint of ...
Cytochrome P450 Genotyping
... enzyme gene resulting in an active molecule are termed extensive metabolizers (EMs; normal). Poor metabolizers (PMs) lack active enzyme gene alleles, and intermediate metabolizers (IMs), who have one active and one inactive enzyme gene allele, may experience to a lesser degree some of the consequenc ...
... enzyme gene resulting in an active molecule are termed extensive metabolizers (EMs; normal). Poor metabolizers (PMs) lack active enzyme gene alleles, and intermediate metabolizers (IMs), who have one active and one inactive enzyme gene allele, may experience to a lesser degree some of the consequenc ...
Nanobodies
... ! Worldwide exclusive rights to commercialise Nanobody products in human healthcare ! ~25 programmes in the R&D pipeline ! Two products achieved clinical proof-of-concepts in RA ! 5 Nanobody products in the clinic - 2 Phase II & 3 Phase I ! Exclusive rights to >500 patent applications and grant ...
... ! Worldwide exclusive rights to commercialise Nanobody products in human healthcare ! ~25 programmes in the R&D pipeline ! Two products achieved clinical proof-of-concepts in RA ! 5 Nanobody products in the clinic - 2 Phase II & 3 Phase I ! Exclusive rights to >500 patent applications and grant ...
![Cucurbit[n]urils as excipients in pharmaceutical dosage forms](http://s1.studyres.com/store/data/005393778_1-462b4ddd8a98f7dba6c184d59041de9f-300x300.png)
Cucurbit[n]urils as excipients in pharmaceutical dosage forms
... exposure to CB[7] (2 days) at concentrations above 500 µM resulted in the death of the zebrafish, but no mortality was observed over shorter (24 h) time periods (19). Overall, the various studies have demonstrated the relative safety of cucurbit[n]urils for drug delivery; however, further research i ...
... exposure to CB[7] (2 days) at concentrations above 500 µM resulted in the death of the zebrafish, but no mortality was observed over shorter (24 h) time periods (19). Overall, the various studies have demonstrated the relative safety of cucurbit[n]urils for drug delivery; however, further research i ...
Chapter-3 Drug and Excipients profile
... in the higher dose groups. The side effect spectrum of Isotretinoin in the rodent thus closely resembles that of vitamin A, but does not include the massive tissue and organ calcifications observed with vitamin A in the rat. The liver cell changes observed with vitamin A did not occur with Isotretin ...
... in the higher dose groups. The side effect spectrum of Isotretinoin in the rodent thus closely resembles that of vitamin A, but does not include the massive tissue and organ calcifications observed with vitamin A in the rat. The liver cell changes observed with vitamin A did not occur with Isotretin ...
DEVELOPMENT AND VALIDATION OF RP-HPLC AND HPTLC METHOD OF ANALYSIS... SIMULTANEOUS ESTIMATION OF AMBROXOL HCL, DEXTROMETHORPHAN HBR AND
... Literature review also revealed that no any method has been developed for simultaneous estimation of AMB, DEX and GUA in single combination dosage form. In this study simple, rapid and sensitive RP-HPLC and HPTLC has been developed. Validation has been done by the ICH guideline Q2R1 [32]. After deve ...
... Literature review also revealed that no any method has been developed for simultaneous estimation of AMB, DEX and GUA in single combination dosage form. In this study simple, rapid and sensitive RP-HPLC and HPTLC has been developed. Validation has been done by the ICH guideline Q2R1 [32]. After deve ...
Guidelines on Preventing Medication Errors in Hospitals
... The pharmacy manager (or designee), with the assistance of the P&T committee (or its equivalent) and the department of nursing, should develop comprehensive policies and procedures that provide for efficient and safe distribution of all medications and related supplies to patients. For safety, the r ...
... The pharmacy manager (or designee), with the assistance of the P&T committee (or its equivalent) and the department of nursing, should develop comprehensive policies and procedures that provide for efficient and safe distribution of all medications and related supplies to patients. For safety, the r ...
Research Report Series from the director:
... ical uses, such as local anesthesia for some eye, ear, and throat surgeries. Cocaine is generally sold on the street as a fine, white, crystalline powder and is also known as “coke,” “C,” “snow,” “flake,” or “blow.” Street dealers generally dilute it with inert substances such as cornstarch, talcum ...
... ical uses, such as local anesthesia for some eye, ear, and throat surgeries. Cocaine is generally sold on the street as a fine, white, crystalline powder and is also known as “coke,” “C,” “snow,” “flake,” or “blow.” Street dealers generally dilute it with inert substances such as cornstarch, talcum ...
LORTAB ® 7.5 mg/500 mg
... Physical dependence usually assumes clinically significant dimensions only after several weeks of continued opioid use, although a mild degree of physical dependence may develop after a few days of opioid therapy. Tolerance, in which increasingly large doses are required in order to produce the same ...
... Physical dependence usually assumes clinically significant dimensions only after several weeks of continued opioid use, although a mild degree of physical dependence may develop after a few days of opioid therapy. Tolerance, in which increasingly large doses are required in order to produce the same ...
IPR2016-01186
... crossover study, eight male volunteers were alternately dosed with a solid dispersion comprising 98 to 102 mg itraconazole and HP-50, and with “100 mg itraconazole as a marketed capsule (SporanoxTM),” after an intervening washout period. Id. at 9:17–45. The pharmacokinetic performance of the two for ...
... crossover study, eight male volunteers were alternately dosed with a solid dispersion comprising 98 to 102 mg itraconazole and HP-50, and with “100 mg itraconazole as a marketed capsule (SporanoxTM),” after an intervening washout period. Id. at 9:17–45. The pharmacokinetic performance of the two for ...
LYOPHILIZED GLICLAZIDEPOLOXAMER SOLID DISPERSIONS FOR ENHANCEMENT OF IN VITRO DISSOLUTION AND INVIVO BIOAVAILABILITY
... Gliclazide (GLC), an oral hypoglycemic agent, is characterized by low solubility in gastric fluid, low dissolution rate and inter‐individual variability in bioavailability. The objective of this study was therefore to design optimized solid dispersions (SD) of GLC with a hydrophilic carrier viz., p ...
... Gliclazide (GLC), an oral hypoglycemic agent, is characterized by low solubility in gastric fluid, low dissolution rate and inter‐individual variability in bioavailability. The objective of this study was therefore to design optimized solid dispersions (SD) of GLC with a hydrophilic carrier viz., p ...
Reflection paper on the data requirements for - EMA
... efficacy and safety compared to the innovator product. In general, the non-clinical studies to be performed prior to clinical studies should include comparative investigation of pharmacokinetics (including tissue distribution), toxicology and pharmacodynamics. However, the complexity of the particul ...
... efficacy and safety compared to the innovator product. In general, the non-clinical studies to be performed prior to clinical studies should include comparative investigation of pharmacokinetics (including tissue distribution), toxicology and pharmacodynamics. However, the complexity of the particul ...
Rectal drug delivery: A promising route for enhancing drug absorption
... such as 5-methoxysalicylate (5MSA) have also been of oleic acid itself does not cause significant enhancements demonstrated as absorption enhancer. Permeability of for the rectal absorption of hydrophilic antibiotics, but when trypan blue in the form of micro enema has been enhanced dosed in a mixed ...
... such as 5-methoxysalicylate (5MSA) have also been of oleic acid itself does not cause significant enhancements demonstrated as absorption enhancer. Permeability of for the rectal absorption of hydrophilic antibiotics, but when trypan blue in the form of micro enema has been enhanced dosed in a mixed ...
Inhaled Adrenergic Bronchodilators: Historical
... Metaproterenol (orciprenaline). Metaproterenol introduced a new generation of  agonists by modifying the catechol ring structure to produce a resorcinol. The hydroxyl groups were shifted from the carbon 3 and 4 positions to the “meta” position of carbons 3 and 5. This prevented degradation by COMT, ...
... Metaproterenol (orciprenaline). Metaproterenol introduced a new generation of  agonists by modifying the catechol ring structure to produce a resorcinol. The hydroxyl groups were shifted from the carbon 3 and 4 positions to the “meta” position of carbons 3 and 5. This prevented degradation by COMT, ...
LORTAB® 7.5/500
... Physical dependence usually assumes clinically significant dimensions only after several weeks of continued opioid use, although a mild degree of physical dependence may develop after a few days of opioid therapy. Tolerance, in which increasingly large doses are required in order to produce the same ...
... Physical dependence usually assumes clinically significant dimensions only after several weeks of continued opioid use, although a mild degree of physical dependence may develop after a few days of opioid therapy. Tolerance, in which increasingly large doses are required in order to produce the same ...
Articaine: Efficacy and Paresthesia in Dental Local
... performance. A thiophene ring replaced the aniline ring on the lipophilic section of the molecule and, for the first time in local anesthetics, a sulfur atom was added within that thiophene structure. Initially, these new chemical entities invited careful scrutiny, even skepticism and criticism amon ...
... performance. A thiophene ring replaced the aniline ring on the lipophilic section of the molecule and, for the first time in local anesthetics, a sulfur atom was added within that thiophene structure. Initially, these new chemical entities invited careful scrutiny, even skepticism and criticism amon ...
SEIKO ABUBAKARI - Kwame Nkrumah University of Science
... Malaria is a public health problem worldwide, especially in tropical Africa where it kills around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an impo ...
... Malaria is a public health problem worldwide, especially in tropical Africa where it kills around a million of people a year, of which 75% are children under 5 years of age, drug assessment in this group is lower which complicate the choice of appropriate treatment. Quinine is re-emerging as an impo ...
Antinociceptive, anti-inflammatory and central nervous system
... from it [3, 4]. It is found in South East Asia, Malaysia, China, India and Australia [4]. Inflammation, associated with pain, is very important for proper functioning of the innate immune system. It protects from antigens and initiates immune responses [5]. Anxiety is responsible for obstacle of eve ...
... from it [3, 4]. It is found in South East Asia, Malaysia, China, India and Australia [4]. Inflammation, associated with pain, is very important for proper functioning of the innate immune system. It protects from antigens and initiates immune responses [5]. Anxiety is responsible for obstacle of eve ...
Celgene Pty Ltd
... following autologous stem cell transplant because the clinical place was not well defined and the submission’s estimate of cost effectiveness was not reliable. The PBAC also noted the low quality of the clinical data presented. Further, the PBAC was concerned that the range of restrictions proposed ...
... following autologous stem cell transplant because the clinical place was not well defined and the submission’s estimate of cost effectiveness was not reliable. The PBAC also noted the low quality of the clinical data presented. Further, the PBAC was concerned that the range of restrictions proposed ...
Gulf War Guinea Pigs: Is Informed Consent Optional During War?
... would become dangerous to humans. 25 During the Cold War, DoD, in conjunction with the Central Intelligence Agency, began experimenting with lysergic acid diethylamide ("LSD") on human subjects.26 Again, the human subjects used in the LSD experiments were not aware of the nature of the tests being p ...
... would become dangerous to humans. 25 During the Cold War, DoD, in conjunction with the Central Intelligence Agency, began experimenting with lysergic acid diethylamide ("LSD") on human subjects.26 Again, the human subjects used in the LSD experiments were not aware of the nature of the tests being p ...
PDF - Medical Journal of Australia
... was a durable success. Now in clinical use for nearly seven decades,2 testosterone is among the oldest marketed drugs, with a long record of safe and effective use for its principal indication of testosterone replacement in androgen deficient men. In addition, testosterone and synthetic androgens ha ...
... was a durable success. Now in clinical use for nearly seven decades,2 testosterone is among the oldest marketed drugs, with a long record of safe and effective use for its principal indication of testosterone replacement in androgen deficient men. In addition, testosterone and synthetic androgens ha ...
Pharmaceutical industry
The pharmaceutical industry develops, produces, and markets drugs or pharmaceuticals for use as medications. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.