Editorial Heart Failure A PKGarious Balancing Act - VU-dare
... ipated to exacerbate the pathophysiology of HFpEF, not only through effects on passive properties but also on remodeling and on systole. In mice harboring myocyte-targeted and controllable PDE5 expression, upregulation (lowered PKG activity) worsened hypertrophy, function, and fibrosis in a pressure ...
... ipated to exacerbate the pathophysiology of HFpEF, not only through effects on passive properties but also on remodeling and on systole. In mice harboring myocyte-targeted and controllable PDE5 expression, upregulation (lowered PKG activity) worsened hypertrophy, function, and fibrosis in a pressure ...
Myocardial Contractility and Assessment of Cardiac Function
... the pulmonary vascular resistance is defined as the difference of mean alveolar pressure and left atrial (LA) pressure divided by pulmonary blood flow. A change in any of these factors may therefore give rise to pulmonary hypertension. Pulmonary hypertension can be either primary, or secondary to ma ...
... the pulmonary vascular resistance is defined as the difference of mean alveolar pressure and left atrial (LA) pressure divided by pulmonary blood flow. A change in any of these factors may therefore give rise to pulmonary hypertension. Pulmonary hypertension can be either primary, or secondary to ma ...
Acute Coronary Syndromes Clinical Care Standard
... coronary syndrome receives a 12-lead electrocardiogram (ECG) and the results are analysed by a clinician experienced in interpreting an ECG within 10 minutes of the first emergency clinical contact. 3 A patient with an acute ST-segment-elevation myocardial infarction (STEMI), for whom emergency repe ...
... coronary syndrome receives a 12-lead electrocardiogram (ECG) and the results are analysed by a clinician experienced in interpreting an ECG within 10 minutes of the first emergency clinical contact. 3 A patient with an acute ST-segment-elevation myocardial infarction (STEMI), for whom emergency repe ...
Functional monitoring of anthracycline cardiotoxicity: a prospective
... Background: With increasing doses the highly tumoricidal anthracycline drugs cause heart damage. Based on empirical drug limitations about 10–15% of patients will develop congestive heart failure (CHF) with a mortality of ∼50% within 2 years on digitalo–diuretic therapy alone. To avoid CHF there is ...
... Background: With increasing doses the highly tumoricidal anthracycline drugs cause heart damage. Based on empirical drug limitations about 10–15% of patients will develop congestive heart failure (CHF) with a mortality of ∼50% within 2 years on digitalo–diuretic therapy alone. To avoid CHF there is ...
Left heart failure
... The heart's response to overload can be divided in three phases that have different functional and prognostic implications. a.) First short-term stage of acute heart failure Clinical: left heart failure, pulmonary congestion Pathological: dilatation of the left ventricle Histological: swelling and ...
... The heart's response to overload can be divided in three phases that have different functional and prognostic implications. a.) First short-term stage of acute heart failure Clinical: left heart failure, pulmonary congestion Pathological: dilatation of the left ventricle Histological: swelling and ...
What proportion of patients with chronic heart failure is eligible for
... are used to define the patient group (K ≤5.4 mmol/L and SBP ≥95 mmHg), then a further 16 patients would have been eligible for sacubitril–valsartan (8 patients had SBP 95–99 mmHg, but 3 had other contraindications, and 15 patients had K = 5.3–5.4 mmol/L, of whom 4 had other contraindications). Lack ...
... are used to define the patient group (K ≤5.4 mmol/L and SBP ≥95 mmHg), then a further 16 patients would have been eligible for sacubitril–valsartan (8 patients had SBP 95–99 mmHg, but 3 had other contraindications, and 15 patients had K = 5.3–5.4 mmol/L, of whom 4 had other contraindications). Lack ...
Sleep and heart failure M.H. Kryger*
... was present in all congestive hear failure (CHF) patients with dyspnoea on sleep onset. They also reported that the breathing pattern could be normal when the patient was awake and became abnormal "at the moment of sleep". After Cheyne-Stokes respiration started "following a long period of apnoea th ...
... was present in all congestive hear failure (CHF) patients with dyspnoea on sleep onset. They also reported that the breathing pattern could be normal when the patient was awake and became abnormal "at the moment of sleep". After Cheyne-Stokes respiration started "following a long period of apnoea th ...
Heart Failure with Preserved Ejection Fraction
... In addition to the higher prevalence of comorbidities associated with HFpEF, their impact on death may be different from reduced HF. For example, chronic obstructive pulmonary disease is associated with increased mortality in patients with HF; however, the risk of death is higher with HFpEF than w ...
... In addition to the higher prevalence of comorbidities associated with HFpEF, their impact on death may be different from reduced HF. For example, chronic obstructive pulmonary disease is associated with increased mortality in patients with HF; however, the risk of death is higher with HFpEF than w ...
PATHOPHYSIOLOGY OF HEART FAILURE
... afterload: due to - elevation of arterial resistance - ventricular size - intrathoracic pressure (loss of myocard) afterload: due to - arterial resistance - myocardial hypertrophy - ventricular size ...
... afterload: due to - elevation of arterial resistance - ventricular size - intrathoracic pressure (loss of myocard) afterload: due to - arterial resistance - myocardial hypertrophy - ventricular size ...
Effect of Surgery for Atrial Fibrillation Associated With Mitral Valve
... f-wave voltage at the V1 lead of more than 0.1 mV. As a result, AF was surgically treated in 147 patients, and the remaining 97 patients were untreated. Preoperative patient characteristics are listed in Table 1. Informed consent was obtained from all patients for examinations and surgical procedure ...
... f-wave voltage at the V1 lead of more than 0.1 mV. As a result, AF was surgically treated in 147 patients, and the remaining 97 patients were untreated. Preoperative patient characteristics are listed in Table 1. Informed consent was obtained from all patients for examinations and surgical procedure ...
Outcome of non-cardiac, non-obstetric surgery in patients with
... controlled as indicated by a median 6MWD of 399 m at the last assessment (within 6 months before surgery) and the fact that 54% of the patients were in NYHA FC I/II at the time of surgery. This may in part explain the low mortality rate of 2% among patients who had non‐emergency surgical interv ...
... controlled as indicated by a median 6MWD of 399 m at the last assessment (within 6 months before surgery) and the fact that 54% of the patients were in NYHA FC I/II at the time of surgery. This may in part explain the low mortality rate of 2% among patients who had non‐emergency surgical interv ...
Comparison of Late Potentials for 24 Hours Between Brugada
... mean age, 33±12 years), who had right ventricular dilation determined using imaging modalities and diagnosed with ARVC as their clinical findings fulfilled the Task Force Criteria of 2010.6 All patients underwent 12-lead ECGs, echocardiography, other diagnostic techniques, such as scintigraphy, heli ...
... mean age, 33±12 years), who had right ventricular dilation determined using imaging modalities and diagnosed with ARVC as their clinical findings fulfilled the Task Force Criteria of 2010.6 All patients underwent 12-lead ECGs, echocardiography, other diagnostic techniques, such as scintigraphy, heli ...
reduced left ventricular systolic function differentiate between
... symptoms related to chronic heart failure.3 These patients may remain asymptomatic for years and when symptoms or clinical signs appear, they are often non-specific and the syndrome may be misdiagnosed. Clinical trials have shown that angiotensin converting enzyme (ACE) inhibitors, spironolactone, a ...
... symptoms related to chronic heart failure.3 These patients may remain asymptomatic for years and when symptoms or clinical signs appear, they are often non-specific and the syndrome may be misdiagnosed. Clinical trials have shown that angiotensin converting enzyme (ACE) inhibitors, spironolactone, a ...
Relationship between endocardial activation sequences defined by
... Published on behalf of the European Society of Cardiology. All rights reserved. & The Author 2011. For permissions please email: journals.permissions@oup.com. ...
... Published on behalf of the European Society of Cardiology. All rights reserved. & The Author 2011. For permissions please email: journals.permissions@oup.com. ...
“Do GRACE (Global Registry of Acute Coronary events) risk scores
... GRACE scores computation. GRACE RS were calculated in each patient from the corresponding prognostic variables scores (online Appendix A). Three risk subgroups (low, intermediate, and high) were defined in each validation cohort according with the respective GRACE scores.17 Calibration and discrimin ...
... GRACE scores computation. GRACE RS were calculated in each patient from the corresponding prognostic variables scores (online Appendix A). Three risk subgroups (low, intermediate, and high) were defined in each validation cohort according with the respective GRACE scores.17 Calibration and discrimin ...
Health Policy Advisory Committee on Technology
... countries, with published trials conducted in Germany and five ongoing clinical trials being conducted in Europe: three in Germany (NCT01175850, NCT01007578 and NCT00640770), and one each in Belgium (NCT01366482) and Austria (NCT01247402). ...
... countries, with published trials conducted in Germany and five ongoing clinical trials being conducted in Europe: three in Germany (NCT01175850, NCT01007578 and NCT00640770), and one each in Belgium (NCT01366482) and Austria (NCT01247402). ...
Usefulness of One-stage Coronary Artery Bypass Grafting on the
... result in end-organ damage. In patients with complications, impaired left ventricular function, poor respiratory function and renal failure, the operative mortality rate of the combined surgery with CPB under cardiac arrest is reported to be 11-25%.16-18) Baumgartner et al.5) document that patients ...
... result in end-organ damage. In patients with complications, impaired left ventricular function, poor respiratory function and renal failure, the operative mortality rate of the combined surgery with CPB under cardiac arrest is reported to be 11-25%.16-18) Baumgartner et al.5) document that patients ...
Enhanced external counterpulsation improves systolic blood
... cells,14 which contribute to improved vascular function in cardiovascular disease.15 Our results with standard blood pressure measurements may represent a physiologic response that integrates the above mechanisms, reflecting both improved endothelial function and vasoreactivity. It is important to e ...
... cells,14 which contribute to improved vascular function in cardiovascular disease.15 Our results with standard blood pressure measurements may represent a physiologic response that integrates the above mechanisms, reflecting both improved endothelial function and vasoreactivity. It is important to e ...
Avoiding Untimely Implantable Cardioverter/Defibrillator
... wearing period instead of ICD implantation were: (1) LVEF at 3-month visit 30% to 35%; (2) increase in LVEF of ≥5% compared to the last visit; and (3) nonoptimized heart failure medication. Mean LVEF was 247% at diagnosis and 3911% at last follow-up (mean, 1210 months). Whereas 88 patients presen ...
... wearing period instead of ICD implantation were: (1) LVEF at 3-month visit 30% to 35%; (2) increase in LVEF of ≥5% compared to the last visit; and (3) nonoptimized heart failure medication. Mean LVEF was 247% at diagnosis and 3911% at last follow-up (mean, 1210 months). Whereas 88 patients presen ...
Apical Hypertrophic Cardiomyopathy: The Ace-of
... identified three predictors of cardiovascular morbidity: age at presentation < 41 years, left atrial enlargement and New York Heart Association functional class II or more at baseline.5 The annual cardiovascular mortality in these patients was of 0.1%.5 One other study (on an Asian population) found ...
... identified three predictors of cardiovascular morbidity: age at presentation < 41 years, left atrial enlargement and New York Heart Association functional class II or more at baseline.5 The annual cardiovascular mortality in these patients was of 0.1%.5 One other study (on an Asian population) found ...
Non-invasive Measurement of Cardiac Output and
... defined as “a state in which the heart fails to maintain an adequate circulation for the needs of the body despite a satisfactory venous filling pressure” [l]. This definition identifies a reduction in cardiac output (Qt) both at rest and during exercise as the key problem in heart failure [2-61. Ho ...
... defined as “a state in which the heart fails to maintain an adequate circulation for the needs of the body despite a satisfactory venous filling pressure” [l]. This definition identifies a reduction in cardiac output (Qt) both at rest and during exercise as the key problem in heart failure [2-61. Ho ...
Congestive Heart Failure Case Study Congestive Heart Failure
... rest; ordinary activities cause symptoms Class 4 – Inability to carry out any physical activity without symptoms – Pain/discomfort at rest ...
... rest; ordinary activities cause symptoms Class 4 – Inability to carry out any physical activity without symptoms – Pain/discomfort at rest ...
Mechanisms of Acute Mitral Regurgitation in Patients
... takotsubo cardiomyopathy (TTC); however, the mechanism of acute MR in TTC remains unclear. The aim of this study was to elucidate the mechanisms of acute MR in patients with TTC. Methods and Results—Echocardiography was used to assess the mitral valve and left ventricular outflow tract (LVOT) pressu ...
... takotsubo cardiomyopathy (TTC); however, the mechanism of acute MR in TTC remains unclear. The aim of this study was to elucidate the mechanisms of acute MR in patients with TTC. Methods and Results—Echocardiography was used to assess the mitral valve and left ventricular outflow tract (LVOT) pressu ...
