product bulletin - Merck Animal Health
... elimination half-life will likely underestimate both the duration of drug action and the concentration of drug remaining at the site of activity. The pharmacokinetic profiles were found to follow a 2-compartmental model, although a deep (third) compartment was observed in some animals. The mean term ...
... elimination half-life will likely underestimate both the duration of drug action and the concentration of drug remaining at the site of activity. The pharmacokinetic profiles were found to follow a 2-compartmental model, although a deep (third) compartment was observed in some animals. The mean term ...
1 SUMMARY OF PRODUCT CHARACTERISTICS 1 - CBG-MEB
... adjustments should be made carefully on an individual patient basis, to maintain the patient at the lowest effective dose. The need for treatment should be reassessed periodically. Some clinicians advocate concomitant behavioural psychotherapy for patients who have done well on pharmacotherapy. Long ...
... adjustments should be made carefully on an individual patient basis, to maintain the patient at the lowest effective dose. The need for treatment should be reassessed periodically. Some clinicians advocate concomitant behavioural psychotherapy for patients who have done well on pharmacotherapy. Long ...
Prescribing Information
... Pediatric Use ELOCON Ointment may be used with caution in pediatric patients 2 years of age or older, although the safety and efficacy of drug use for longer than 3 weeks have not been established. Since safety and efficacy of ELOCON Ointment have not been established in pediatric patients below 2 y ...
... Pediatric Use ELOCON Ointment may be used with caution in pediatric patients 2 years of age or older, although the safety and efficacy of drug use for longer than 3 weeks have not been established. Since safety and efficacy of ELOCON Ointment have not been established in pediatric patients below 2 y ...
HIV Pharmacotherapy Focused Update
... • May cause renal dysfunction • Dose adjustments needed for CrCL <50mL/min, ...
... • May cause renal dysfunction • Dose adjustments needed for CrCL <50mL/min, ...
Pharmacometrics and Biostatistics Interactions at the FDA
... Example contributed by John Lawrence, DJ Marathe, James Hung, Sue-Jane Wang ...
... Example contributed by John Lawrence, DJ Marathe, James Hung, Sue-Jane Wang ...
Is there a difference between an angiotensin
... but the ARB did not reduce coronary heart disease significantly. Heart failure was significantly reduced by both the ACE inhibitor and the ARB. When used as monotherapy, neither of these two agents reduced cardiovascular mortality or all-cause mortality, probably because of the underlying use of mul ...
... but the ARB did not reduce coronary heart disease significantly. Heart failure was significantly reduced by both the ACE inhibitor and the ARB. When used as monotherapy, neither of these two agents reduced cardiovascular mortality or all-cause mortality, probably because of the underlying use of mul ...
Inhalation Anesthetic Agents
... Compazine – Compazine is an anti-emetic, used for the control of severe nausea and vomiting. With an intra-muscular injection, the onset of action is within 10-20 minutes and a duration of three to four hours. Total parenteral dosage should not exceed 40 mg per day. It is recommended that Compazine ...
... Compazine – Compazine is an anti-emetic, used for the control of severe nausea and vomiting. With an intra-muscular injection, the onset of action is within 10-20 minutes and a duration of three to four hours. Total parenteral dosage should not exceed 40 mg per day. It is recommended that Compazine ...
What is mental life
... Typical Antipsychotics (1st generation antipsychotics aka Neuroleptics) o The original antipsychotics o Even though these are older medications, they are sometimes the 1st line drugs (e.g. Haloperidol where IV delivery is needed) o DOPAMINE ANTAGONISTS Atypical Antipsychotics (2nd generation antipsy ...
... Typical Antipsychotics (1st generation antipsychotics aka Neuroleptics) o The original antipsychotics o Even though these are older medications, they are sometimes the 1st line drugs (e.g. Haloperidol where IV delivery is needed) o DOPAMINE ANTAGONISTS Atypical Antipsychotics (2nd generation antipsy ...
SULFAMETHOXAZOLE/TRIMETHOPRIM `Co
... prevent and treat a particular chest infection called Pneumocystis Jiroveci (Carinii) pneumonia. You may hear the doctors and nurses referring to this pneumonia as ‘PCP’. This infection is due to an organism (bug) which is probably present in most people’s lungs. Children who are receiving long term ...
... prevent and treat a particular chest infection called Pneumocystis Jiroveci (Carinii) pneumonia. You may hear the doctors and nurses referring to this pneumonia as ‘PCP’. This infection is due to an organism (bug) which is probably present in most people’s lungs. Children who are receiving long term ...
Analgesic
... acute respiratory depression renal failure (due to accumulation of the metabolites morphine-3glucuronide and morphine-6-glucuronide) chemical toxicity (potentially lethal in low tolerance subjects) raised intracranial pressure, including head injury (risk of worsening respiratory depression) ...
... acute respiratory depression renal failure (due to accumulation of the metabolites morphine-3glucuronide and morphine-6-glucuronide) chemical toxicity (potentially lethal in low tolerance subjects) raised intracranial pressure, including head injury (risk of worsening respiratory depression) ...
Tussionex®
... Pediatric Use: In pediatric patients, as well as adults, the respiratory center is sensitive to the depressant action of narcotic cough suppressants in a dose-dependent manner. Benefit to risk ratio should be carefully considered especially in pediatric patients with respiratory embarrassment (e.g., ...
... Pediatric Use: In pediatric patients, as well as adults, the respiratory center is sensitive to the depressant action of narcotic cough suppressants in a dose-dependent manner. Benefit to risk ratio should be carefully considered especially in pediatric patients with respiratory embarrassment (e.g., ...
DM, GI, Vitamins
... Vitamin K deficiency may be caused by breast-feeding, severe liver disease, malabsorption syndromes, or chronic broadspectrum antibiotic use. Phytonadione is routinely given to neonates at birth (one dose of 1 mg) to prevent hemorrhage. Microbiologic flora of gut manufactures most of vitamin K ...
... Vitamin K deficiency may be caused by breast-feeding, severe liver disease, malabsorption syndromes, or chronic broadspectrum antibiotic use. Phytonadione is routinely given to neonates at birth (one dose of 1 mg) to prevent hemorrhage. Microbiologic flora of gut manufactures most of vitamin K ...
SOLU-MEDROL (methylprednisolone sodium succinate for injection, USP
... Increased dosage of rapidly acting corticosteroids is indicated in patients on corticosteroid therapy who are subjected to any unusual stress before, during, and after the stressful situation. ...
... Increased dosage of rapidly acting corticosteroids is indicated in patients on corticosteroid therapy who are subjected to any unusual stress before, during, and after the stressful situation. ...
click on dosing chart to download.
... Prednisolone sodium phosphate oral solution (25 mg prednisolone per 5 mL) produces a 14% higher peak plasma level of prednisolone which occurs 20% faster than that seen with tablets. Prednisolone is 70-90% protein-bound in the plasma, and it is eliminated from the plasma with a half-life of 2 to 4 h ...
... Prednisolone sodium phosphate oral solution (25 mg prednisolone per 5 mL) produces a 14% higher peak plasma level of prednisolone which occurs 20% faster than that seen with tablets. Prednisolone is 70-90% protein-bound in the plasma, and it is eliminated from the plasma with a half-life of 2 to 4 h ...
File - Developing Anaesthesia
... Rivaroxaban (trade name in Australia “Xarelto”), is a drug from a novel class of noncoumarin anticoagulants, (loosely known as NOACs or “New Oral Anticoagulants”) which is an orally active direct Factor Xa inhibitor. It offers some significant therapeutic advantages over warfarin, but is more proble ...
... Rivaroxaban (trade name in Australia “Xarelto”), is a drug from a novel class of noncoumarin anticoagulants, (loosely known as NOACs or “New Oral Anticoagulants”) which is an orally active direct Factor Xa inhibitor. It offers some significant therapeutic advantages over warfarin, but is more proble ...
Mycophenolate for Interstitial Lung Disease
... Mycophenolate Mofetil for Interstitial Lung Disease, this is an unlicensed indication. (NB: not for use in idiopathic pulmonary fibrosis (IPF). Prescribing responsibility will only be transferred when: ...
... Mycophenolate Mofetil for Interstitial Lung Disease, this is an unlicensed indication. (NB: not for use in idiopathic pulmonary fibrosis (IPF). Prescribing responsibility will only be transferred when: ...
respiratory depression due to clonazepam and fluconazole
... Drug-drug interaction is defined as alteration of the effects of one drug by the prior or concomitant or simultaneous administration of another drug. The concomitant use of multiple drugs, leads to possibility of occurring drug-drug interactions and these interactions may be severe to cause morbidit ...
... Drug-drug interaction is defined as alteration of the effects of one drug by the prior or concomitant or simultaneous administration of another drug. The concomitant use of multiple drugs, leads to possibility of occurring drug-drug interactions and these interactions may be severe to cause morbidit ...
Rx Only USE IN PREGNANCY
... pulmonary vascular resistance, increased cardiac output, and increased exercise tolerance time (ETT) have been demonstrated. These hemodynamic and clinical effects occur after the first dose and appear to persist for the duration of therapy. Placebo controlled studies of 12 weeks duration in patien ...
... pulmonary vascular resistance, increased cardiac output, and increased exercise tolerance time (ETT) have been demonstrated. These hemodynamic and clinical effects occur after the first dose and appear to persist for the duration of therapy. Placebo controlled studies of 12 weeks duration in patien ...
- Boehringer Ingelheim (Canada)
... inhibitors (dipeptidyl peptidase-4 inhibitors). Linagliptin helps to improve blood sugar levels when they are high, especially after a meal. Linagliptin also helps to decrease the amount of sugar made by the body. Metformin is a member of the biguanide class of medicines. It helps to lower the amoun ...
... inhibitors (dipeptidyl peptidase-4 inhibitors). Linagliptin helps to improve blood sugar levels when they are high, especially after a meal. Linagliptin also helps to decrease the amount of sugar made by the body. Metformin is a member of the biguanide class of medicines. It helps to lower the amoun ...
Drugs - PHARMACEUTICAL REVIEW
... a- Dosage form: Solution > Suspension >Tablet b- Shape & size of particles and rates of disintegration & dissolution of tables: ...
... a- Dosage form: Solution > Suspension >Tablet b- Shape & size of particles and rates of disintegration & dissolution of tables: ...
Sorafenib (MRCC)
... sorafenib (Nexavar) provides clinical efficacy in the second-line treatment of MRCC after failure to cytokine therapy. Although there were concerns regarding cost-effectiveness, the Committee recognized that sorafenib (Nexavar) offers a treatment option for a select number of patients who have faile ...
... sorafenib (Nexavar) provides clinical efficacy in the second-line treatment of MRCC after failure to cytokine therapy. Although there were concerns regarding cost-effectiveness, the Committee recognized that sorafenib (Nexavar) offers a treatment option for a select number of patients who have faile ...
Product Information - PICO
... Reproduction studies with sodium picosulfate performed in animals have revealed no evidence of a harmful action on the fetus. However, clinical experience of the use of PICO-SALAX® during pregnancy is limited and caution should be observed, particularly during the first trimester. It is not known wh ...
... Reproduction studies with sodium picosulfate performed in animals have revealed no evidence of a harmful action on the fetus. However, clinical experience of the use of PICO-SALAX® during pregnancy is limited and caution should be observed, particularly during the first trimester. It is not known wh ...
PRODUCT INFORMATION ANADA 200
... PHARMACOLOGY: Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. In vitro, gentamicin is bactericidal against a wide variety of gram-positive and gram-negative bacteria isolated from domestic animals.1,2 Specifically, gentamicin is ...
... PHARMACOLOGY: Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. In vitro, gentamicin is bactericidal against a wide variety of gram-positive and gram-negative bacteria isolated from domestic animals.1,2 Specifically, gentamicin is ...
Bilastine
Bilastine (trade name Bilaxten) is a second generation antihistamine drug for the treatment of allergic rhinoconjunctivitis and urticaria (hives).It exerts its effect as a selective histamine H1 receptor antagonist, and has a effectiveness similar to cetirizine, fexofenadine and desloratadine. It was developed in Spain by FAES Farma.Bilastine is approved in the European Union for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria, but it is not approved by the U.S. Food and Drug Administration for any use in the United States. Bilastine meets the current European Academy of Allergy and Clinical Immunology (EAACI) and Allergic Rhinitis and its Impact of Asthma (ARIA) criteria for medication used in the treatment of allergic rhinitis.Bilastine has been effective in the treatment of ocular symptoms and diseases of allergies, including rhinoconjuctivitis. Additionally, bilastine has been shown to improve quality of life, and all nasal and ocular symptoms related to allergic rhinitis.