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Full Text PDF - Science and Education Publishing
Full Text PDF - Science and Education Publishing

... constant drug plasma levels to improve patient compliance and the amount of drug available at targeting site is lower than that of the oral route, but the absorbed dose appears to be sufficient for therapeutic use without inducing any ...
INT_CAT_NGO_RUS_13012_E
INT_CAT_NGO_RUS_13012_E

... treatment. Aside from the principle of non-discrimination and respect for the rights of drug users, the law must contain the following principles: 1. The principle of non-punishment for drug use and related actions, including purchasing and possession of drugs with no intent to supply;4 2. The princ ...
Role of Novel Drug Delivery Systems in
Role of Novel Drug Delivery Systems in

... channels and a large interfacial area and bicontinous cubic phases are optically isotropic, very viscous and solid like liquid crystalline substance with cubic crystallographic symmetry15. Cubic phases were produced at 25 ºC in water monoolein-alcohol mixtures. Ethanol was found to be more efficient ...
rajiv gandhi university of health sciences
rajiv gandhi university of health sciences

... The antihypertensive are a class of drugs that are used to treat hypertension (high blood pressure). Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality f ...
Mixing and compatibility guide for commonly used aerosolized
Mixing and compatibility guide for commonly used aerosolized

... package insert or direct communication with the manufacturer. Red shading with corresponding letter X indicates that there is evidence confirming or suggesting that a particular admixture is not compatible. Yellow shading with corresponding letters NI indicates that there is insufficient evidence to ...
PHARMACY TECHNICIAN (PHT) 720 clock hours/ 36 weeks (Total
PHARMACY TECHNICIAN (PHT) 720 clock hours/ 36 weeks (Total

Development of Room Temperature Stable Formulation of
Development of Room Temperature Stable Formulation of

... hydrofluoroalkane (HFA) pressurized metered dose inhalers (pMDI) for lung delivery. The HFA pMDI were prepared from ozone friendly propellants viz, tetrafluoroethane and/or heptafluoropropane. A HFA based formulation of formoterol fumarate/ beclomethasone dipropionate was developed to deliver 6 +100 ...
THE KOREAN HERBAL PHARMACOPOEIA
THE KOREAN HERBAL PHARMACOPOEIA

... 7. In stating the amount of content in pharmaceutical preparations, the use of an expression “not less than 95.0% and not more than 105.0%” or “not less than 95.0% and not more than 110.0%”, for example, indicates that it is usually prepared so as to contain the labeled amount of the chemically pure ...
EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION
EFFECT OF POLOXAMER 188 ON IN VITRO DISSOLUTION

... to inadequate and variable bioavailability1, 2. Based upon their solubility and permeability characteristics, the Biopharmaceutical Classification System (BCS) categorizes drugs in two major classes, class II and IV3. The BCS class II drugs are poorly water-soluble entities with high permeability. T ...
Drugs for Parasitic Infections
Drugs for Parasitic Infections

... Nitazoxanide is FDA-approved as a pediatric oral suspension for treatment of Cryptosporidium in immunocompetent children <12 years old and for Giardia (Medical Letter 2003; 45:29). It may also be effective for mild to moderate amebiasis (E Diaz et al, Am J Trop Med Hyg 2003; 68:384). Nitazoxanide is ...
Presentation - Poorly water soluble substances: challenges
Presentation - Poorly water soluble substances: challenges

... • Alcohol like CNS effects, slower metabolism below 4-5 years, metabolites renally excreted; seizures possible • May contribute to lactic acidosis and hyperosmolality, (hyperosmolality of formulation also risk in oral dosing for prematures; NEC) • What is a safe level after single dose/over treatmen ...
GUIDANCE TO SURVEYORS - LONG TERM CARE FACILITIES
GUIDANCE TO SURVEYORS - LONG TERM CARE FACILITIES

... her/his room or confinement to her/his room (with or without roommates) against the resident’s will, or the will of the resident’s legal representative. Emergency or short term monitored separation from other Residents will not be considered involuntary seclusion and may be permitted if used for a l ...
WHO Guide lines Inner soreads
WHO Guide lines Inner soreads

... with an adverse medical event (or laboratory test abnormality) suspected to be induced by a medicine. A case report should (as a minimum to aim at) contain information on the following elements: 1. The patient: age, sex and brief medical history (when relevant). In some countries ethnic origin may n ...
The effect of food and gastrointestinal residence on drug
The effect of food and gastrointestinal residence on drug

... Briefly, this study investigated a marketed erythromycin product (Erycl® 250 mg, Parke-Davis) administered under tasted and non-fasted conditions. An extremely important distinction in dosing regimen between this study and others which have previously evaluated gastrointestinal transit (4) was that ...
A fatal outcome after unintentional overdosing of rivastigmine patches
A fatal outcome after unintentional overdosing of rivastigmine patches

... indicated in patients with advanced age or patients whose medication is controlled by ambulatory teams with frequent change of staff members. During the same year two additional reports with multiple rivastigmine patches were sent to the Regional Pharmacovigilance Centre in Linköping suggesting that ...
a novel approach using hydrotropic solubalization technique
a novel approach using hydrotropic solubalization technique

Letter to the Editor - Drug Metabolism and Disposition
Letter to the Editor - Drug Metabolism and Disposition

Pharmaceutical and Medical Pharmaceutical and Medical
Pharmaceutical and Medical Pharmaceutical and Medical

... 324 general chapters illustrated with diagrams or chromatograms, and 2440 descriptions of reagents. The texts cover active substances, excipients, substances or preparations for pharmaceutical use of chemical, animal, human or herbal origin, homoeopathic preparations and stocks, antibiotics, as well ...
Assessment of Drug−Lipid Complex Formation by a High
Assessment of Drug−Lipid Complex Formation by a High

... known to cause PLD in humans.13,31 In fact, following their classification these compounds would have smaller risk than imipramine and clozapine, which are generally considered weak PLD inducers.22,32 Also the pathology score of Sawada et al. for amiodarone deviates from published data.7,33 Low PLD ...
EFFECT OF VARIOUS ENVIRONMENTAL /PROCESSING FACTORS ON STABILITY OF THE FORMULATION AND
EFFECT OF VARIOUS ENVIRONMENTAL /PROCESSING FACTORS ON STABILITY OF THE FORMULATION AND

... 1. At higher temp., there is less relative humidity & O2 solubility , thus hindering the predictability of RT stability of drug sensitive to presence of moisture and oxygen. 2. For dispersed systems, viscosity is decreased as temp. is increased and physical characteristics may be altered, resulting ...
A drug or device shall be deemed to be misbranded—
A drug or device shall be deemed to be misbranded—

... the outside container of the retail package and, if determined to be appropriate by the Secretary, on the immediate container, as prescribed in regulation promulgated by the Secretary, except that nothing in this subclause shall be deemed to require that any trade secret be divulged, and except that ...
Ada_Dekhtyar
Ada_Dekhtyar

... supervision of medical professionals, not to prevent self-medication which utilized relatively safe drugs such as aspirin or “Mothersill’s seasick pills.”12 Regarding determination of a drug’s prescription or over-the-counter status under section 503(b)(1), Congress intended extensive inquiry to occ ...
Pharmacy Council of India
Pharmacy Council of India

... Class shall be awarded at the end of I, II, III, IV, V and final year of Pharm. D examination as shown below: 1) Distinction ...
Introduction to Pharmacokinetics and Pharmacodynamics
Introduction to Pharmacokinetics and Pharmacodynamics

... of the resulting concentration data to develop safe and effective drug regimens. If performed properly, this process allows for the achievement of therapeutic concentrations of a drug more rapidly and safely than can be attained with empiric dose changes. Together with observations of the drug’s cli ...
INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO
INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO

... use and storage. 4. It should possess suitable anti-microbial to prevent from microbial attack. 5. The topical gel should not be tacky. 6. The ophthalmic gel should be sterile. 7. It should be economical. Structure of Gels [9]: The rigidity of a gel arises from the presence of a network formed by th ...
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Compounding

Pharmaceutical compounding (done in compounding pharmacies) is the creation of a particular pharmaceutical product to fit the unique need of a patient. To do this, compounding pharmacists combine or process appropriate ingredients using various tools. This may be done for medically necessary reasons, such as to change the form of the medication from a solid pill to a liquid, to avoid a non-essential ingredient that the patient is allergic to, or to obtain the exact dose(s) needed or deemed best of particular active pharmaceutical ingredient(s). It may also be done for more optional reasons, such as adding flavors to a medication or otherwise altering taste or texture. Compounding is most routine in the case of intravenous/parenteral medication, typically by hospital pharmacists, but is also offered by privately owned compounding pharmacies and certain retail pharmacies for various forms of medication. Whether routine or rare, intravenous or oral, etc., when a given drug product is made or modified to have characteristics that are specifically prescribed for an individual patient, it is known as ""traditional"" compounding.Due to the rising cost of compounding and the shortage of drugs, many hospitals have shown a tendency to rely more upon large-scale compounding pharmacies to meet their regular requirement, particularly of sterile-injectable medications. When compounding is done on bulk production of a given formulation rather than patient-specific production, it is known as ""non-traditional"" compounding (which, as discussed below, is arguably not ""compounding"" but rather ""manufacturing""). This development raises concerns about patient safety and makes a case for proper regulatory control and monitoring.
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