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`party drugs` in people living with HIV on
`party drugs` in people living with HIV on

... David Backd and Marta Boffitoa,b,e Use of ‘party drugs’, a particular set of recreational drugs used in the context of ‘ChemSex’, is frequent among MSM living with HIV. A recently published observational study showed that more than half of HIV-infected MSM interviewed reported use of illicit substan ...
Clinical Pharmacokinetics and Pharmacodynamics
Clinical Pharmacokinetics and Pharmacodynamics

... and Pharmacodynamics (PD)? • Individualize patient drug therapy • Monitor medications with a narrow therapeutic index • Decrease the risk of adverse effects while maximizing pharmacologic response of medications • Evaluate PK/PD as a diagnostic tool for underlying disease states ...
proper usage of drugs, chemicals and feed additives in food animals
proper usage of drugs, chemicals and feed additives in food animals

... recover may subsequently abort. At the first sign of any adverse reaction, discontinue use of this product and administer epinephrine at the recommended dosage levels. Call a veterinarian immediately. Shock may be observed following intravenous administration, especially where highly concentrated ma ...
Basic Principles of Pharmacology
Basic Principles of Pharmacology

... Not always required prior to early studies in man unless there is a high suspicion that the drug could be carcinogenic e.g. suspicion of mutagenicity; highly reactive groups on drug; histopathological abnormalities… Required if the use of drug in man for more than one year or +ve mutagenic test ...
two new third-generation antiepileptic drugs
two new third-generation antiepileptic drugs

... 1857 when bromides salts were recognized as having antiseizure activity. Next, two drugs –phenobarbital and phenytoin became available in the first 50 years of the twentieth century. 16 new AEDs were discovered between 1946 and Vol . 21/2012, nr 42 ...
Understanding Pharmacokinetics & Drug-Drug Interactions
Understanding Pharmacokinetics & Drug-Drug Interactions

... – Must be adequate at time of new drug application (NDA) to support concomitant dosing – Studies for clinically important but less frequently used drugs can be conducted post-marketing • Early discussions with regulatory agencies, community and investigators can help prioritize conduct of studies ...
Clinical Pharmacokinetics and Pharmacodynamics
Clinical Pharmacokinetics and Pharmacodynamics

... CLINICAL PRACTICE Select appropriate drug for clinical indication ...
AN INDIVIDUAL BASED STUDY OF THE GERIATRIC POPULATION: A POLYPHARMACY
AN INDIVIDUAL BASED STUDY OF THE GERIATRIC POPULATION: A POLYPHARMACY

... or more disorders. In addition to that atypical disease presentation and physician prescribing habits have resulted in multiple drugs use. Major Polypharmacy was often occurred as 95.88 % of the patients received more than 5 drugs and 4.12% of them had been prescribed with 2-5 drugs. The regular med ...
examination for Parkistan students (1)
examination for Parkistan students (1)

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Clinical Trials of Traditional Herbal Medicines In India
Clinical Trials of Traditional Herbal Medicines In India

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Pharmaceutical Regulatory and Compliance Congress and Best
Pharmaceutical Regulatory and Compliance Congress and Best

... e) State of Ohio v. Bristol-Myers Squibb Co., Civ. No. 1:02-CV01080 (Ohio, filed June 2002) – In June 2002, 29 states7 along with the District of Columbia, Puerto Rico and the Virgin Islands filed suit against the maker of an anti-cancer drug in the United States District Court for the District of ...
and drug
and drug

... Be courteous of your fellow students. You may come in late, leave early, sleep, eat, drink, read the newspaper, text message your friends, listen to your iPod, … Just do it quietly and do not disturb other students who are trying to pay attention to the lecture. ...
Withdrawing Drugs in the US Versus Other Countries
Withdrawing Drugs in the US Versus Other Countries

... withdrawn. Thus, it is very important that the consumer as well as the practitioner become aware of dangerous drugs. In 1979 the United Nations General Assembly first brought up the question of establishing a list of banned pharmaceutical products that could be exchanged between nations. Under resol ...
Controlled drug release
Controlled drug release

... The ultimate criteria of for evaluating such dosage forms are: the amount of drug intended to be absorbed is indeed absorbed in a predictable and consistent manner 2. the steady state ratio of maximum to minimum drug conc is no greater or optimally less than that produced by the more frequently admi ...
Controlled drug release
Controlled drug release

... The ultimate criteria of for evaluating such dosage forms are: the amount of drug intended to be absorbed is indeed absorbed in a predictable and consistent manner 2. the steady state ratio of maximum to minimum drug conc is no greater or optimally less than that produced by the more frequently admi ...
Benton Daly (Fall `10  file)
Benton Daly (Fall `10 file)

... cases of heart attack and strokes associated with patients who were taking Avandia. The Food and Drug Administration (FDA) has required GSK to put more warnings of the drug’s risks on the bottle. The FDA also conducted a study where they discovered that a person who takes Avandia is 43% more at risk ...
PREVALENCE AND ASSESSMENT OF POLYPHARMACY IN SRI DEVRAJ URS MEDICAL... & HOSPITAL, KOLAR  Research Article
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... expenditures directly due to the cost of superfluous medication, but also indirectly due to the increased number of hospitalizations caused by drug-related complications18. The beneficial effect of reducing the occurrence of PP in the population has been addressed in order to cut down on expenditure ...
PSNZ Submission - Towards NZ Medicines Strategy
PSNZ Submission - Towards NZ Medicines Strategy

... products are frequently not funded. This has, in part, been addressed by the Hospital Exceptional Circumstances (HEC) approval, however this application process places an extra burden on the time restraints of hospital medical and pharmacy personnel. Following HEC approval the medicines can only be ...
Bioavailability and Bioequivalence: General
Bioavailability and Bioequivalence: General

... • Solutions for oral use ( syrups, elixirs, tinctures & other soluble forms but not suspensions) • Pdrs for reconstitution as a solution • Otic or ophthalmic aqueous solutions • Topical aqueous solutions • Aqueous nebulizing inhalations or nasal sprays ...
therequiv - Weatherford High School
therequiv - Weatherford High School

... • Solutions for oral use ( syrups, elixirs, tinctures & other soluble forms but not suspensions) • Pdrs for reconstitution as a solution • Otic or ophthalmic aqueous solutions • Topical aqueous solutions • Aqueous nebulizing inhalations or nasal sprays ...
Drugs
Drugs

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Street Drugs
Street Drugs

... risk of dependence on this drug, along with potential for interaction with other drugs. Some users may use cannabis to counteract the effects of stimulant medications, with the possibility of severe anxiety and panic attacks. Other interactions include potential for overdose when under the influence ...
Pharmacognosy-I
Pharmacognosy-I

... • Pharmacognosy is the study of those natural substances, principally plants that find use in medicine. • Pharmacognosy: derived from the Greek, pharmakon a drug and gnosis in knowledge . • Pharmacognosy: may be defined as a science that deals with the biological, biochemical, and economic feature o ...
Successful Drug Discovery, Volume 1 Brochure
Successful Drug Discovery, Volume 1 Brochure

... The first volume of the book series Successful Drug Discovery is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds: small–molecule–, peptide–, and protein–based drugs. The role of serendipity is analyzed in some very successful ...
For acids
For acids

... compounds from natural sources or the synthesis of new molecules the trying to investigate the relationships between the chemical structure of these compounds and their biological activities. ...
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Orphan drug

An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.According to Thomson Reuters in their 2012 publication ""The Economic Power of Orphan Drugs"", there has been increased investing in orphan drug Research and Development partly due to the U. S. Orphan Drug Act (ODA) 1983 and similar Acts in other regions of the world and also driven by ""high-profile philanthropic funding."" The period between 2001 to 2011 was the ""most productive period in the history of orphan drug development, in terms of average annual orphan drug designations and orphan drug approvals."" For the same decade the compound annual growth rate (CAGR) of the orphan drugs was an ""impressive 25.8 percent, compared to only 20.1 percent for a matched control group of non-orphan drugs."" By 2012 the market for orphan drugs was worth USD$637 million compared to the USD$638 million matched control group of non-orphan drugs, Thomson Reuters.By 2012, ""the revenue-generating potential of orphan drugs [was] as great as for non-orphan drugs, even though patient populations for rare diseases are significantly smaller. Moreover, we suggest that orphan drugs have greater profitability when considered in the full context of developmental drivers including government financial incentives, smaller clinical trial sizes, shorter clinical trial times and higher rates of regulatory success.""
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