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What changes in the brain when we learn?
What changes in the brain when we learn?

... generates a series of prototypical electrical signals called “spikes” (Fig. 1, lower right). Each of these spikes has a rather constant shape and amplitude. It is therefore of a digital type – it either exists (in full amplitude and a fixed duration) or it does not exists at all. When a sensory stim ...
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... Alzheimer’s Disease and its Effects on the Central Nervous System Alzheimer’s disease (AD) is a progressive brain disorder that gradually destroys a person’s memory and his ability to learn, make judgments, communicate, and carry out daily activities as well as eventually bringing about his or her ...
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... with reactions to circumstances, such as instigating the processes involved in the fight-or-flight reflex, while the second is generally associated with relaxation and inhibition. Prior research has found that these two types differ in some respects—those in the sympathetic system generally have adr ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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