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pdf, 282 KB - NHS Basildon and Brentwood CCG
pdf, 282 KB - NHS Basildon and Brentwood CCG

... equivalents available. Please consider the use of the requisition route for the supply of some of the magnesium oxide preparations (details available from the Medicines Management Team). Alternatively, please ensure that prescriptions for magnesium oxide and magnesium glycerophosphate are written as ...
Safer Prescribing of Antidepressants Guidelines
Safer Prescribing of Antidepressants Guidelines

... antidepressant prescribing guidance for providers, clients and the interested general public to increase the effectiveness and safety of antidepressant use. It is not intended to be comprehensive in scope. These recommendations are not a substitute for clinical judgment, and decisions about care mus ...
Ecchymosis Related to Paroxetine and Sertraline
Ecchymosis Related to Paroxetine and Sertraline

... been reported in increasing numbers of patients in recent years (2-4). Both antidepressants described in this report are frequently used worldwide, but the side effect of ecchymoses is very rare. This case was diagnosed as ecchymoses associated with paroxetine and sertraline. Other causes were exclu ...
Side effects
Side effects

... very limited CYP 2D6 enzyme activity. Such “poor metabolizers” may find standard doses of tricyclic antidepressants intolerable and it is often worth starting at a very low dose. ...
Behavior Products and Medications
Behavior Products and Medications

... and thus it must be tried at home prior to the pet experiencing the stressor/trigger. Although bite disinhibition can occur with any psychotropic medications, as a class, the benzodiazepines appear to cause this more frequently and caution should be exercised when using benzodiazepines in dogs with ...
Treating hot flushes: An alternative to hormonal replacement therapy
Treating hot flushes: An alternative to hormonal replacement therapy

... The dose can be increased every four to seven days until the recommended dose is reached, which is 75mg daily4, 5. Take venlafaxine with food once a day preferably at the same time each day. Food may lessen any nausea feeling that the medicine may cause. Do not divide, crush, chew or place capsules ...
`Let Them Eat Prozac` - Introduction: The SSRI Issues
`Let Them Eat Prozac` - Introduction: The SSRI Issues

... In the face of this series of setbacks, Astra contemplated withdrawing from the research-based pharmaceutical market, in favor of a focus on over-thecounter medicines. Around 1990, it was estimated that new FDA regulations and other hurdles to drug development meant that the cost of bringing a drug ...
Introduction - Let them Eat Prozac
Introduction - Let them Eat Prozac

... In the face of this series of setbacks, Astra contemplated withdrawing from the research-based pharmaceutical market, in favor of a focus on over-thecounter medicines. Around 1990, it was estimated that new FDA regulations and other hurdles to drug development meant that the cost of bringing a drug ...
Document name: ANTIDEPRESSANTS FOR THE TREATMENT OF
Document name: ANTIDEPRESSANTS FOR THE TREATMENT OF

... ulcers. The risk of gastric bleeding is increased when aspirin, clopidogrel or NSAIDS are co-prescribed. The elderly and those with a previous history of bleeding are at greatest risk. Gastroprotective drugs such as omeprazole or lansoprazole should be considered in patients taking SSRIs with risk f ...
Antidepressants, Nootropic drugs and CNS Stimulants
Antidepressants, Nootropic drugs and CNS Stimulants

... Depression is one of the most common psychiatric disorders. At any given moment, about 3–5% of the population is depressed, and an estimated 10% of people may become depressed during their lives. The symptoms of depression are often subtle and unrecognized both by patients and by physicians. Patien ...
Document
Document

... being mediated by a large and diverse range of 5-HT receptors. At least seven different receptor "families" are known to exist, each located in different parts of the body and triggering different responses. As with all neurotransmitters, the effects of 5-HT on the human mood and state of mind, and ...
Information Guide ot Antidepressants | March 2009
Information Guide ot Antidepressants | March 2009

... reduce the dose and increase slower. In the elderly, the debilitated or those sensitive to medications, start lower. For all antidepressants, allow four weeks at a therapeutic dose, then assess for response. If only partial or slight response (well tolerated), then increase the dose. If no response, ...
Maternal use of SSRIs, SNRIs and NaSSAs
Maternal use of SSRIs, SNRIs and NaSSAs

... toxicity in another individual patient. Therefore, the term serotonin reuptake inhibitor (SRI)-related symptoms is used. The SRI-related symptoms occur in approximately 30% of in utero exposed infants.45 48 Several additional factors, like maternal dose and metabolism, the specific SSRI used, the ind ...
antidepressants: what they are and how they work
antidepressants: what they are and how they work

... Once the neurotransmitter molecules are released by the presynaptic cell, they migrate across the synapse through a series of chemical and electrical impulses. They are then capable of binding to receptors that are located on the surface of the postsynaptic nerve cell. Receptors are tiny proteins th ...
Table 2
Table 2

... lines, including the Burkitt Lymphoma cells. Other drugs had limited effect, either less potent or in selective cell lines only. Fluoxetine and maprotiline were further studied and found to have anti-proliferative potential with other malignancies and to manifest selective toxicity to malignant cell ...
Choosing Antidepressants for HIV and AIDS Patients
Choosing Antidepressants for HIV and AIDS Patients

... a half-life by 220 percent.13 Theoretical interactions. Outside of these measured effects, knowledge about the metabolism of other similar antidepressant medications can lead to theoretical effects of combination with antiretroviral medications. Many SSRIs and new multireceptor targeting medications ...
Amitriptylin Abcur film-coated tablet ENG SmPC
Amitriptylin Abcur film-coated tablet ENG SmPC

... (predominantly aggression, oppositional behaviour and anger) were more frequent in clinical studies in children and adolescents treated with antidepressants compared to those treated with a placebo. In addition, TCAs are associated with a risk of cardiovascular adverse events in all age groups. In a ...
Psychopharmacology Antipsychotics Ameliorate symptoms of psychosis
Psychopharmacology Antipsychotics Ameliorate symptoms of psychosis

... o Pregnancy  All are C except clozapine which is B Antidepressants o Uses: acute and maintenance tx of major depression, dysthymia, bipolar, panic d/o, agoraphobia, OCD, PTSD, GAD, social phobia, bulimia nervosa ...
Journal about antidepressant drugs U.N 42904891 Date:18
Journal about antidepressant drugs U.N 42904891 Date:18

... Have a family or personal history of successful treatment with MAOIs ...
Psychopharm Dr Tim Lau 2010_compressed
Psychopharm Dr Tim Lau 2010_compressed

... of the major active metabolite of venlafaxine (Effexor) It is being targeted as the first nonhormonal based treatment for menopause. Theoretically useful for slow 2D6 metabolizers ...
Document
Document

... disorder may be thought of as a gender-specific form of brief recurrent depression, and it is known to be responsive to SSRIs. A randomized, double-blind, placebo-controlled study evaluated flexible doses of venlafaxine therapy (range from 50 to 200 mg per day) across four menstrual cycles among 157 ...
ANTIDEPRESSANTS: SSRIs (p.1) 1. Introduction SSRIs (Selective
ANTIDEPRESSANTS: SSRIs (p.1) 1. Introduction SSRIs (Selective

... almost the efficacy of imipramine/Tofranil with no cardiovas SEs ? more acceptable/fewer side effects --- greater compliance rates allowed possibility of treating Ss with milder depression/dysthymia Pharmacokinetics: PO, absorbed through GI tract peak plasma levels in 6-8 hours about 94% protein bou ...
See PDF - Journal of Clinical Psychiatry
See PDF - Journal of Clinical Psychiatry

... 5. Murdoch D, McTavish D. Sertraline: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs 1992;44:604–624 6. Prozac (fluoxetine). Compendium of Pharmaceuticals and Specialties. 31st ed. Ottawa, Ontario, Cana ...
Serotonin Syndrome
Serotonin Syndrome

... Serotonin Syndrome (also called serotonin toxicity or serotonin toxidrome) is not an idiosyncratic drug reaction; it is a predictable consequence of an excess of serotonergic activity at both peripheral and central nervous system receptors. This drug utilization review identified Idaho Medicaid part ...
Appendix C: First-Line Antidepressants
Appendix C: First-Line Antidepressants

... • § SSRIs have “flat” dose-response curves. For depression, most patients respond to initial lower dose. Higher doses are used for treatment of OCD. Do not dose until steady state is reached (i.e., ~4 weeks for fluoxetine, and 1-2 weeks for others). • Therapeutic effect seen after 7-28 days. • Ci ...
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Fluoxetine



Fluoxetine (also known by the trade names Prozac, and Sarafem, among others) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine was discovered and developed by scientists from Eli Lilly and Company. It was approved by the U.S. Food and Drug Administration for the treatment of major depressive disorder in December 1987. The U.S. fluoxetine patent expired in August 2001, so generic formulations are now available in the U.S.Fluoxetine is used for the treatment of major depressive disorder (including pediatric depression), obsessive–compulsive disorder (in both adults and children), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. In addition, it is used to treat trichotillomania if cognitive behaviour therapy has been unsuccessful.In 2010, over 24.4 million prescriptions for generic formulations of fluoxetine were filled in the United States, making it the third-most prescribed antidepressant after sertraline and citalopram. In 2011, 6 million prescriptions for fluoxetine were filled in the United Kingdom. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.
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