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1.7AMIDES
1.7AMIDES

... bonds are polar. As a result the physical properties of amides are similar to carboxylic acids. 1) Primary amides have two N-H bonds so they have even stronger hydrogen bonds than carboxylic acid. Secondary amides also have one N-H bond and experience hydrogen bonding. Tertiary amides do not experie ...
Biology Slide 1 of 39 End Show
Biology Slide 1 of 39 End Show

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CHEM 212B, Organic Chemistry - City College of San Francisco
CHEM 212B, Organic Chemistry - City College of San Francisco

... polarity, dipole moments, boiling point trends, solubility, and reactivity of different functional groups. c. Predict the product of organic reactions of conjugated alkenes, aromatics, carbonyl compounds, amines, carbohydrates, lipids, and amino acids. D. Write detailed mechanisms for pericyclic rea ...
Pandemic Flu - Egan Supply Co.
Pandemic Flu - Egan Supply Co.

... large proportion of the human population. – The World Health Organization (WHO) warns that there is a substantial risk of an Pandemic Flu within the next few years. – Pandemic Flu is an infectious disease of birds and mammals caused by an RNA virus of the family Orthomyxovidridae (the influenza viru ...
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Bacterial immunostimulants in recurrent paediatric respiratory

nomenclature continued… - Turner Fenton Secondary School
nomenclature continued… - Turner Fenton Secondary School

... 1. Find longest alkyl chain containing Nitrogen. 2. Replace alkane with amine. Include position of carbon attached to nitrogen. 3. If there are 2 or more alkyl groups attached to the nitrogen then use N as a prefix. Note: a nitrogen can have a maximum of three alkyl groups attached therefore the nam ...
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Visualizing Macromolecules

... ____________________________ . Clearly the number of possible combinations is almost infinite when larger numbers of amino acids are combined to form a polypeptide. 3. What is PRIMARY STRUCTURE? ______________________________________________________________________________ __________________________ ...
Nucleic Acids - University of California, Davis
Nucleic Acids - University of California, Davis

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Protein Structure III

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12–3 RNA and Protein Synthesis

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Tr-dT, 2-cyanoethanol
Tr-dT, 2-cyanoethanol

... pyridine with the main types of the reactive phosphorylating intermediates formed by treatment of pdT-Act pdTpdT-Ac, Tr-dTpdT-Ac, Tr-dTpdTpdT-Ac with 2,4,6-triisopropylbenzenesulfonyl chloride (TPS): 1) B type derivatives with phosphomono ester ( M E ) group converted to a phosphoryl pyridinium resi ...
MRSA Fact Sheet - Student Health Center
MRSA Fact Sheet - Student Health Center

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05_GENE_EXPRESSION
05_GENE_EXPRESSION

...  Fairly stable  Found in ribosomes  Made as subunits in the nucleolus  rRNA provides the platform from protein synthesis ...
Ester - SCH4U-SRB
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... Esters are responsible for the “fruity” odours and flavours of many naturally occurring products. Chemists can reproduce these odours or flavours in the lab by mixing the right alcohol and carboxylic acid together; thus, producing “artificial” or “synthetic” versions of these naturally occurring com ...
Synthesis of the hexoses
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... route has a decisive advantage. Combined with the benzenethiolate opening reaction, trans-2,Bepoxy alcohols give erythro-2,3-diols and cis-2,3-epoxy alcohols give three-2,3-diols. ...
Paper chromatography and electrophoresis
Paper chromatography and electrophoresis

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Friedel-Crafts Alkylations (Exp.II)
Friedel-Crafts Alkylations (Exp.II)

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Gene expression: Transcription
Gene expression: Transcription

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PHL 224 Biochemistry II

... 2. Solubility: Most of the amino acids are usually soluble in water and insoluble in organic solvents. 3. Melting points: Amino acids generally melt at higher temperatures, often above 200°C. 4. Taste: Amino acids may be sweet (Gly, Ala, Val), tasteless (Leu) or bitter (Arg, lle). Monosodium glutama ...
Multistep Small-Molecule Synthesis Programmed by
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... methods used to purify reaction products are not suitable for synthesis on the molecular biology (picograms to micrograms) scale. To address the first of these challenges, we implemented three distinct strategies for linking chemical reagents with their decoding DNA oligonucleotides, inspired by pre ...
Chemical Synthesis of Oligonucleotides
Chemical Synthesis of Oligonucleotides

... Scale refers to the amount of starting material which is composed solely of the 3’-most nucleotide of a sequence attached to a solid support used to make the oligonucleotide. Yield refers to the amount of final product recovered after all the synthesis, processing, and purification steps associated ...
CHEM1102 2014-J-8 June 2014 • Complete the following table
CHEM1102 2014-J-8 June 2014 • Complete the following table

Protein Synthesis I
Protein Synthesis I

... 2. When that codon is read, enzyme stops translation and essentially cuts off the protein so no new amino acid is added to the growing polypeptide chain d. The looseness of these codes is remarkable, but there is a reason we will discuss e. This is classic redundancy i. You would call this degenerat ...
From Gene to Protein—Transcription and Translation
From Gene to Protein—Transcription and Translation

< 1 ... 48 49 50 51 52 53 54 55 56 ... 152 >

Bottromycin



Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic.Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored.The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been determined as of 2009. In 2012, a three-dimensional solution structure of bottromycin was published. The solution structure revealed that several methyl groups are on the same face of the structure.Bottromycin falls within the ribosomally synthesized and post-translationally modified peptide class of natural product.
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