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Name: _ Date: Block: ____ A.1 Basic Biological Principles
Name: _ Date: Block: ____ A.1 Basic Biological Principles

...  Deletion – big part of chromosome sequence deleted  Duplication – big part of chromosome sequence repeated  Inversion- part of chromosome sequence inverted (reversed)  Translocation – part of one chromosome is moved to another chromosome  Nondisjunction – during meiosis when a sex cell ends up ...
TRANSCRIPTION-TRANSLATION PROTEIN SYNTHESIS
TRANSCRIPTION-TRANSLATION PROTEIN SYNTHESIS

... 1.DNA is transcribed to mRNA which is the chemical that is to be read like a language. It has the letters AUCG instead of our 26 letter alphabet 2. You have to know what direction to read in. English is right to left but Arabic is left to right. RNA is read in a 5’ to 3’ direction ...
Biological Diversity Topic 5
Biological Diversity Topic 5

... • Recall that when organisms divide through binary fission, the two new organisms created are identical. • In order for them to be identical, they have to have the same DNA. • In order for this to happen, the parent must double its DNA before it divides. • In multicellular organisms, that production ...
Section 3: DNA is the inherited material responsible for variation
Section 3: DNA is the inherited material responsible for variation

... 14) Dominant Trait (explain & give an example): __________________________________________ __________________________________________________________________________________ __________________________________________________________________________________ 15) Recessive Trait (explain & give an exam ...
Chapter 4
Chapter 4

... Hydrolysis is the opposite of dehydration synthesis. In hydrolysis, a large molecule is split apart at a certain point and a hydrogen atom is attached to one of the new molecules, while a hydroxyl group is attached to the other. Both of these processes can occur over and over until the original mole ...
Computational methods for the analysis of bacterial gene regulation
Computational methods for the analysis of bacterial gene regulation

... of adjacent genes is within an operon together or not (transcriptional unit boundary). Using advanced machine learning methods and extensive training sets, operon prediction methods have achieved a good efficiency in predicting whether genes are co‐transcribed (se ...
DNA is the genetic material DNA structure
DNA is the genetic material DNA structure

... All 3 kinds of RNA are involved in translation 1. rRNA: crucial part of the ribosome which catalyzes synthesis of new proteins 2. mRNA: the blueprint; information-carrying molecule which dictates the amino acid sequence of a new protein 3. tRNA: tRNA (transfer RNA) translates nucleotide sequences in ...
DOC - MIT
DOC - MIT

Golden Rice, or Frankenfood?
Golden Rice, or Frankenfood?

... with gene for rat growth hormone  Gene was integrated into mouse DNA  Engineered mice were 1-1/2 times ...
Short read alignment, genome alignment, and high performance
Short read alignment, genome alignment, and high performance

... Short read alignment • Input: – Reads: short DNA sequences usually up to 100 base pairs (bp) produced by a sequencing machine • Reads are fragments of a longer DNA sequence present in the sample given as input to the machine • Usually number in the millions ...
Lab 1 Introduction to nucleic acids Structural Properties
Lab 1 Introduction to nucleic acids Structural Properties

... Guanine pairs with cytosine (three Hbonds) and adenine pairs with thymine (two H-bonds) (law of complementary base pairing). ...
Gene-order Comparisons
Gene-order Comparisons

... • In a given organism, genes are found in a given order that is maintained on the chromosomes. • On the other hand, genes with a related function are frequently found to be clustered at one chromosome location • Example : tryptophan genes in different prokaryotic organisms • Observation: – At least ...
DNA to Protein - byrdistheword
DNA to Protein - byrdistheword

...  Two populations of ribosomes are evident in cells: free ribsomes (in the cytosol) and bound ribosomes (attached to the ER)  Free ribosomes mostly synthesize proteins that function in the cytosol  Bound ribosomes make proteins of the ...
Document
Document

...  Genome sequencing has allowed scientists to identify most of the genes encoded in each organism  The function of many, typically 50%, of translated proteins can be inferred from sequence comparison with previously characterized sequences  The assignment of function by homology gives only a parti ...
Edvotek Kit #116: Genetically Inherited Disease Detection Using Pre
Edvotek Kit #116: Genetically Inherited Disease Detection Using Pre

... Sickle Cell results from a Point Mutation on the short arm of chromosome 11. A single nucleotide polymorphism (SNP) between an A to T results in a new amino acid in the sixth position of the beta chain of hemoglobin in red blood cells. In normal hemoglobin (Hb A), glutamic acid (Glu) is present. In ...
NBT Briefing - EcoNexus December 2015
NBT Briefing - EcoNexus December 2015

... to  go  through  the  regulatory  process  for  GMOs,  whilst  choosing  names  that  make  it  difficult   for  the  public  to  see  that  genetic  engineering  (genetic  modification)  is  being  used.  This  goes   alongside  efforts ...
Genetic Changes - Down the Rabbit Hole
Genetic Changes - Down the Rabbit Hole

... Significance of Mutations Most are neutral • Eye color • Birth marks • Some are harmful • Cystic Fibrosis • Down Syndrome • Some are beneficial • Sickle Cell Anemia to Malaria • Immunity to HIV ...
Genes Reading Group, Minutes 4. (Dec 4)
Genes Reading Group, Minutes 4. (Dec 4)

... extracellular context. E.g. not clear if non-coding, regulatory regions are counted as genes or as context. We assume he subscribes to some form of a contemporary molecular gene concept, a sequence whose product is translated, with different products depending on the context (CtMG, see Griffiths/Neu ...
Chapter 5 Mutation and genetic variation
Chapter 5 Mutation and genetic variation

... tauschii which has a total of 14 chromosomes (DD) produced a sterile hybrid with 21 chromosomes (ABD). Further polyploid error in meiosis produced T. aestivum Bread Wheat with 42 chromosomes (AABBDD). Those chromosomes are derived from 3 ancestral ...
Lecture 28
Lecture 28

... energy but “prefer” to utilize glucose. Thus, when the organisms are growing on glucose, the gene products for catabolism of other sugars are not synthesized. This led initially to the concept of structural genes and regulatory genes. 2. There are different levels at which gene expression can be reg ...
No Slide Title
No Slide Title

... They exist separate from the main chromosome They replicate within the host cells Their size vary form ~ 1,000 to 250,000 base pairs They can be divided into two broad groups according to how tightly their replication in regulated: 1. stringent plasmids (low copy number plasmids: 1-2 plasmids/cell) ...
Unit 7: Heredity and Biotechnology
Unit 7: Heredity and Biotechnology

... 5. Plasmids or viruses are then used as a vector, a genetic vehicle that carries foreign DNA into a host cell 6. The recombinant DNA inside the host cell reproduces new cells that contain copies of the inserted gene. These new copies of the gene are considered clones, so this process is called cloni ...
Unit 5: Gene Expression and Mutation Genetics 2013
Unit 5: Gene Expression and Mutation Genetics 2013

... more or less abundant in cancer cells than in healthy ones ...
Genomics: A new Revolution in Science
Genomics: A new Revolution in Science

... Around 99% of our genes have counterparts in mice Our genetic overlap with chimpanzees is about 97.5% The genetic difference between one person and another is less than 0.1 % • But because only a few regions of DNA actively encode life functions, the real difference between one person and another is ...
Document
Document

... What does the mutation do to the other genes and proteins in an affected cell? One gene can affect many others We can measure changes that result from the mutation by looking at the genes that are turned on in cells that have the mutation and comparing to normal cells Typically, we end up with large ...
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Artificial gene synthesis

Artificial gene synthesis is a method in synthetic biology that is used to create artificial genes in the laboratory. Currently based on solid-phase DNA synthesis, it differs from molecular cloning and polymerase chain reaction (PCR) in that the user does not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits on either nucleotide sequence or size. The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs. Recent research also suggests the possibility of creating novel nucleobase pairs in addition to the two base pairs in nature, which could greatly expand the possibility of expanding the genetic code.Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of the first peptide- and protein-coding genes was performed in the laboratories of Herbert Boyer and Alexander Markham, respectively.Commercial gene synthesis services are now available from numerous companies worldwide, some of which have built their business model around this task. Current gene synthesis approaches are most often based on a combination of organic chemistry and molecular biological techniques and entire genes may be synthesized ""de novo"", without the need for precursor template DNA. Gene synthesis has become an important tool in many fields of recombinant DNA technology including heterologous gene expression, vaccine development, gene therapy and molecular engineering. The synthesis of nucleic acid sequences is often more economical than classical cloning and mutagenesis procedures.
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