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Isoprenoid metabolism: cholesterol and the others
Isoprenoid metabolism: cholesterol and the others

... rate limiting step of the whole pathway and as such it determines how much cholesterol (and other isoprenoids) we can make per unit time. hmg-CoA is reduced by the enzyme hmg-CoA reductase to mevalonate. The unusual thing about this step is that a carboxyl group (or, more specifically, a thioester g ...
Full Text  - The International Journal of Developmental Biology
Full Text - The International Journal of Developmental Biology

... cells in the outer ventricular zone and celis corresponding to neuroblasts in the intermediate zone. The ventral quarter of the ventricular zone did not show any signal. In the caudal part 01 the spinal cord, PAX2hybridization was restricted only to the outer part of the ventricular zone, while it w ...
Genome-Wide Scan of Obesity in the Old Order Amish*
Genome-Wide Scan of Obesity in the Old Order Amish*

... between these traits ranged from 0.30 (waist circumference and percent fat) to 0.83 (leptin and percent fat). Leptin concentrations were strongly correlated with BMI (r ⫽ 0.66); however, as shown in Fig. 1, there was considerable variation in leptin concentrations even among individuals with the sam ...
BMC Microbiology
BMC Microbiology

... Their presence could point towards the existence of sexual reproduction in A. niger or a broader role for the gene products in physiology, than just sexual development. ...
Candidate gene scan for Single Nucleotide Polymorphisms involved
Candidate gene scan for Single Nucleotide Polymorphisms involved

Tangping Li, Ke Fan, Jun Wang and Wei Wang Reduction of protein
Tangping Li, Ke Fan, Jun Wang and Wei Wang Reduction of protein

... P in each group (n1, n2, ¼, nN) (Wang and Wang, 1999) with Niˆ1 ni = 20, we can always ®nd a speci®c grouping of residues with a maximal value of S, i.e. S = S¢max. Such a grouping is regarded as the best or the most reasonable one since it may reserve the maximal information on the parent sequence ...
Tandem duplications and the limits of natural
Tandem duplications and the limits of natural

... Tandem duplications are an essential source of genetic novelty, and their variation in natural populations is expected to influence adaptive walks. Here, we describe evolutionary impacts of recently-derived, segregating tandem duplications in Drosophila yakuba and Drosophila simulans. We observe an ...
Sample Integrity in qPCR: Using PIPETMAX® qPCR
Sample Integrity in qPCR: Using PIPETMAX® qPCR

... reason, sample integrity is crucial. A sample that has been contaminated may produce a false positive, and thereby negatively impacting critical research or a clinical analysis. The inclusion of proper controls, such as positive and negative, helps to avoid confusion late in the analysis process. Wh ...
4. Inducers of apoptosis
4. Inducers of apoptosis

coloured foal booklet - British Skewbald and Piebald Association
coloured foal booklet - British Skewbald and Piebald Association

... producing a coloured foal at each breeding. For example out of 10 matings this stallion may have nine coloured foals, however in the next 10 matings she may only have one coloured foal and nine solid foals. Never be misled into thinking you are more likely to get a coloured foal from any heterozygou ...
LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs
LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs

... construction of the primary neural network (ages zero to two years in humans, zero to one week in mice, and estimated zero to one to two months in dogs). In humans, this phase generates a network of approximately one quadrillion synapses. The second phase, pruning (ages two to 10 years in humans, se ...
Mutations in type I collagen genes resulting in osteogenesis
Mutations in type I collagen genes resulting in osteogenesis

... Osteogenesis imperfecta (OI), commonly known as “brittle bone disease”, is a dominant autosomal disorder characterized by bone fragility and abnormalities of connective tissue. Biochemical and molecular genetic studies have shown that the vast majority of affected individuals have mutations in eithe ...
Fingerprinting and Identification of Bacteria Present in UASB
Fingerprinting and Identification of Bacteria Present in UASB

... peach-lye canning granules. Of the 68 bacteria, 24 were representative of uncultured bacteria, constituting 35% of the identified bacteria. The remaining 65% were culturable bacteria. In Table 1, a summary is provided of the number given to each unique DGGE band, whether it was identified from clone ...
Correlation of amino acid preference and
Correlation of amino acid preference and

... Three types of analysis are conducted. At the genome level, crossvalidation is used to demonstrate the predictive capability of amino acid preference of viral genome type. Next at the sequence level, two types of resampling analysis are used to investigate the correlation of amino acid preference an ...
Full Text
Full Text

... evaluated for LTN in the greenhouse at Cornell University, Ithaca, NY during Fall 2011. The progenies of these lines were evaluated in the field at the Kenya Agricultural Research Institute, Njoro, Kenya during the main and off seasons, 2012. But, only 393 lines could be scored during the Njoro main ...
Identification of Quantitative Trait Loci That Affect Aggressive
Identification of Quantitative Trait Loci That Affect Aggressive

... were bred at Princeton University in a separate breeding colony room. For breeding, one male and one female mouse were housed together. The male was removed from the cage before the birth of the pups. Litters were culled to no more than five pups during the first 3 postnatal days. Pups were weaned a ...
4 Molecular Genetics of Coat Colour, Texture and Length in the Dog
4 Molecular Genetics of Coat Colour, Texture and Length in the Dog

... examples of dog colour or hair mutations for which there is not an obvious homologue in other mammals, such as Dominant black (K), Harlequin, or the coat characteristic known as furnishings – facial furnishings, such as a beard, moustache or eyebrows – (RSPO2). These examples probably reflect the hi ...
gmod-arthrobase-07dec - IUBio Archive for Biology
gmod-arthrobase-07dec - IUBio Archive for Biology

... are needed to see this picture. ...
Adaptative biochemical pathways and regulatory networks in
Adaptative biochemical pathways and regulatory networks in

... EPS production by adapting metabolic and biochemical processes in order to face iron toxicity and to optimize energy production. ...
Practice Guidelines for the Molecular Diagnosis of Haemophilia B.
Practice Guidelines for the Molecular Diagnosis of Haemophilia B.

... DNA sequencing is considered the gold standard for mutation detection. F9 is small enough to contemplate sequencing the coding region, splice junctions, and the 5’ & 3’ regions for previously unknown mutations (Vidal et al 2000), within the time constraints of a diagnostic service. Normally a candid ...
There is more than one way to search the medical literature
There is more than one way to search the medical literature

... publishing trends can also be established. PubFocus also uses citation information to determine author rankings and most prolific authors. There are also special subsets of data based on the NCI thesaurus and the Mouse Genome Database mammalian gene orthology. PubMed Gold http://www.neurotransmitter ...
Semantic WebMelbourn.. - Buffalo Ontology Site
Semantic WebMelbourn.. - Buffalo Ontology Site

... local file, and then set up some FOPL rules that say "if file 'a' contains the information Joe loves mary and has the checksum md5:0qrhf8q3hfh, then record SuccessA", "if file 'b' contains the information MJS is equivalent to Mary, and has the checksum md5:0892t925h, then record SuccessB", and "if S ...
The Meaning of Sex: Genes and Gender Lecture Three—Sex and
The Meaning of Sex: Genes and Gender Lecture Three—Sex and

... The little worm, C. elegans, has come up with its own solution. It, too, must have dosage compensation, and what it does is slightly different from the human. In the case of the nematode, once again, the two X chromosomes of the hermaphrodite and the one X chromosome of the male ultimately make the ...
METABOLIC ADAPTATION OF CANDIDA
METABOLIC ADAPTATION OF CANDIDA

... The gene conferring resistance, ATP dependent transporters are highly expressed in planktonic cells and early phase of biofilm, thereby decreasing susceptibility (Murkejee et al., 2003). However, their absentia function in mature biofilm resistance shows that other molecular mechanisms and genes are ...
Biology 30 June 1999 Grade 12 Diploma Exam
Biology 30 June 1999 Grade 12 Diploma Exam

... regeneration. Studies show that neurons of the CNS are capable of regeneration when NGF is produced by genetically engineered cells that are transplanted in the CNS. from Greene, 1993 ...
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Artificial gene synthesis

Artificial gene synthesis is a method in synthetic biology that is used to create artificial genes in the laboratory. Currently based on solid-phase DNA synthesis, it differs from molecular cloning and polymerase chain reaction (PCR) in that the user does not have to begin with preexisting DNA sequences. Therefore, it is possible to make a completely synthetic double-stranded DNA molecule with no apparent limits on either nucleotide sequence or size. The method has been used to generate functional bacterial or yeast chromosomes containing approximately one million base pairs. Recent research also suggests the possibility of creating novel nucleobase pairs in addition to the two base pairs in nature, which could greatly expand the possibility of expanding the genetic code.Synthesis of the first complete gene, a yeast tRNA, was demonstrated by Har Gobind Khorana and coworkers in 1972. Synthesis of the first peptide- and protein-coding genes was performed in the laboratories of Herbert Boyer and Alexander Markham, respectively.Commercial gene synthesis services are now available from numerous companies worldwide, some of which have built their business model around this task. Current gene synthesis approaches are most often based on a combination of organic chemistry and molecular biological techniques and entire genes may be synthesized ""de novo"", without the need for precursor template DNA. Gene synthesis has become an important tool in many fields of recombinant DNA technology including heterologous gene expression, vaccine development, gene therapy and molecular engineering. The synthesis of nucleic acid sequences is often more economical than classical cloning and mutagenesis procedures.
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