Essentials of Glycobiology Lecture 13 April 25th. 2000
... “High-Uptake” and “Low-Uptake” Forms of Lysosomal Enzymes • Soluble "corrective factors" turned out be different lysosomal enzymes deficient in patients with different diseases - being secreted by the normal cells in small amounts • Enzymes found to exist in two forms: a "high-uptake" form that cou ...
... “High-Uptake” and “Low-Uptake” Forms of Lysosomal Enzymes • Soluble "corrective factors" turned out be different lysosomal enzymes deficient in patients with different diseases - being secreted by the normal cells in small amounts • Enzymes found to exist in two forms: a "high-uptake" form that cou ...
TMEM65 is a mitochondrial inner-membrane protein
... Mitochondrial dysfunction leads to a variety of disease (Schapira, 2006), including Leigh syndrome. Deficiency of the respiration complex IV (cytochrome c oxidase) is commonly observed in Leigh syndrome patients (Schapira, 2006; Huntsman et al., 2005). Mitochondrial disorder enhances anaerobic ener ...
... Mitochondrial dysfunction leads to a variety of disease (Schapira, 2006), including Leigh syndrome. Deficiency of the respiration complex IV (cytochrome c oxidase) is commonly observed in Leigh syndrome patients (Schapira, 2006; Huntsman et al., 2005). Mitochondrial disorder enhances anaerobic ener ...
Cellular Energetics
... • e- are passed down the ETC via redox reactions until they reach the final e- acceptor (O2) to form water • No ATP is made by ETC; must be coupled to oxidative phosphorylation via chemiosmosis (diffusion of H+ across the membrane) ...
... • e- are passed down the ETC via redox reactions until they reach the final e- acceptor (O2) to form water • No ATP is made by ETC; must be coupled to oxidative phosphorylation via chemiosmosis (diffusion of H+ across the membrane) ...
Document
... The liver is the metabolic hub of the body. It makes the fuel that supplies the brain, muscles, and other organs. The liver plays a central role in the regulation of carbohydrate, lipid, and amino acid metabolism. The liver removes about two-thirds of the glucose absorbed by the intestine and conver ...
... The liver is the metabolic hub of the body. It makes the fuel that supplies the brain, muscles, and other organs. The liver plays a central role in the regulation of carbohydrate, lipid, and amino acid metabolism. The liver removes about two-thirds of the glucose absorbed by the intestine and conver ...
PYRIMIDINE METABOLISM
... There are basically two types of salvage. The first involves attachment of the base to PRPP with the formation of pyrophosphate. This pathway is available for salvage of purines and uracil but not for cytosine or thymine. The other pathway involves attachment of the base to ribose 1-phosphate, which ...
... There are basically two types of salvage. The first involves attachment of the base to PRPP with the formation of pyrophosphate. This pathway is available for salvage of purines and uracil but not for cytosine or thymine. The other pathway involves attachment of the base to ribose 1-phosphate, which ...
01st lecture
... (Gels: some macromolecules in solutions – like proteins or carbohydrates – form a crosslinked structure holding the liquid in form. This shows a quasi-solid properties – like jelly or jam.) ...
... (Gels: some macromolecules in solutions – like proteins or carbohydrates – form a crosslinked structure holding the liquid in form. This shows a quasi-solid properties – like jelly or jam.) ...
(Heterobasidion annosum) in
... and inducible physical and chemical barriers. Preformed physical barriers include thorns, bark and cuticular waxes, and chemical defences comprise a range of antimicrobial compounds. In healthy plants, there is a tendency for these compounds to be either concentrated in the outer cell layers of plan ...
... and inducible physical and chemical barriers. Preformed physical barriers include thorns, bark and cuticular waxes, and chemical defences comprise a range of antimicrobial compounds. In healthy plants, there is a tendency for these compounds to be either concentrated in the outer cell layers of plan ...
Biochemical fossils of the ancient transition from geoenergetics to
... link to modern microbial physiology, nor did it take into account the vexing ubiquity of chemiosmotic coupling among modern cells [114]. From our standpoint, having a link to modern microbes is important, because very many different possible sources of energy for early biochemical systems can be env ...
... link to modern microbial physiology, nor did it take into account the vexing ubiquity of chemiosmotic coupling among modern cells [114]. From our standpoint, having a link to modern microbes is important, because very many different possible sources of energy for early biochemical systems can be env ...
mukesh-kumar-all-india-institute-of-medical
... » PAP is an isozyme of alkaline phosphatase » 513 amino acid peripheral membrane glycoprotein anchored ...
... » PAP is an isozyme of alkaline phosphatase » 513 amino acid peripheral membrane glycoprotein anchored ...
Nature: Serine is a natural ligand and allosteric activator of pyruvate
... fuel-efficient mode in which more pyruvate is diverted to the mitochondria and more glucose-derived carbon is channelled into serine biosynthesis to support cell proliferation. Metabolic fluxes in cancer cells are different from those in nontransformed cells1. In particular, a shift from oxidative p ...
... fuel-efficient mode in which more pyruvate is diverted to the mitochondria and more glucose-derived carbon is channelled into serine biosynthesis to support cell proliferation. Metabolic fluxes in cancer cells are different from those in nontransformed cells1. In particular, a shift from oxidative p ...
public exam_respiration__R1
... 11. Drugs X and Y may inhibit enzymes involved in glycolysis, the Krebs cycle or oxidative phosphorylatin. To study the effects of the drugs, some muscle cells were isolated and treated with these two drugs separately in the presence of oxygen. The cellcular levels of ATP, NADH, and pyruvate were de ...
... 11. Drugs X and Y may inhibit enzymes involved in glycolysis, the Krebs cycle or oxidative phosphorylatin. To study the effects of the drugs, some muscle cells were isolated and treated with these two drugs separately in the presence of oxygen. The cellcular levels of ATP, NADH, and pyruvate were de ...
A macrokinetic and regulator model for myeloma cell culture based
... However, it is found that the real glucose uptake rate is much lower than rglc,M at the beginning of cultivation, even though the glucose concentration is the highest. Such discrepancy exists for most Monod type models because the Monod model does not take the induction of the enzyme pool involved i ...
... However, it is found that the real glucose uptake rate is much lower than rglc,M at the beginning of cultivation, even though the glucose concentration is the highest. Such discrepancy exists for most Monod type models because the Monod model does not take the induction of the enzyme pool involved i ...
Pyruvate dehydrogenase complex
... –binds to the allosteric site and inhibits the action of the enzyme –usually it is the end product of a biosynthetic pathway - end-product (feedback) inhibition • Positive modulator (activator) –binds to the allosteric site and stimulates activity –usually it is the substrate of the reaction ...
... –binds to the allosteric site and inhibits the action of the enzyme –usually it is the end product of a biosynthetic pathway - end-product (feedback) inhibition • Positive modulator (activator) –binds to the allosteric site and stimulates activity –usually it is the substrate of the reaction ...
(β/α)8-barrel enzymes present in completely sequenced genomes
... (1999) have proposed that the absence of PK may indicate the presence of yet another undetected enzyme which has displaced the “classical” form of PK. This fact is not too surprising because the other important metabolic pathway of the citricacid cycle was found to be incomplete or absent in several ...
... (1999) have proposed that the absence of PK may indicate the presence of yet another undetected enzyme which has displaced the “classical” form of PK. This fact is not too surprising because the other important metabolic pathway of the citricacid cycle was found to be incomplete or absent in several ...
Poster for RCPSC mee.. - University of Alberta
... From the Canadian Institutes of Health Research, Group in Protein Structure and Function and the Signal Transduction Research Group, the Departments of Biochemistry* and Pharmacology^, Faculty of Medicine, University of Alberta, Edmonton, Alberta T6G 2H7, Canada Introduction ...
... From the Canadian Institutes of Health Research, Group in Protein Structure and Function and the Signal Transduction Research Group, the Departments of Biochemistry* and Pharmacology^, Faculty of Medicine, University of Alberta, Edmonton, Alberta T6G 2H7, Canada Introduction ...
Rapid increase of cytosolic content of acetyl-CoA
... malonyl-CoA from acetyl-CoA and CO2 which is the ratelimiting step in fatty acid biosynthesis (Wakil et al., 1983; Numa and Tanabe, 1984). Malonyl-CoA serves as a precursor of fatty acid biosynthesis and an intermediate of fatty acid elongation, but it also acts as an allosteric inhibitor of carniti ...
... malonyl-CoA from acetyl-CoA and CO2 which is the ratelimiting step in fatty acid biosynthesis (Wakil et al., 1983; Numa and Tanabe, 1984). Malonyl-CoA serves as a precursor of fatty acid biosynthesis and an intermediate of fatty acid elongation, but it also acts as an allosteric inhibitor of carniti ...
Medical Biochemistry Review #2 By
... enzyme phosphofructokinase-2/fructose-2,6bisphosphatase (PFK-2/F-2,6-BPase). • In the nonphosphorylated form the enzyme is known as PFK-2 and serves to catalyze the synthesis of F2,6BP by phosphorylating fructose 6-phosphate. • The result is that the activity of PFK-1 is greatly stimulated and the a ...
... enzyme phosphofructokinase-2/fructose-2,6bisphosphatase (PFK-2/F-2,6-BPase). • In the nonphosphorylated form the enzyme is known as PFK-2 and serves to catalyze the synthesis of F2,6BP by phosphorylating fructose 6-phosphate. • The result is that the activity of PFK-1 is greatly stimulated and the a ...
"Neurotransmitter Receptors in the Postsynaptic Neuron". In
... and an effector molecule, which is an enzyme that catalyses the production of intracellular messengers. Metabotropic receptors are the largest family of neurotransmitter receptor. The prototype is the b-adrenergic receptor, which itself has structural (but not amino acid sequence!) homology to the pr ...
... and an effector molecule, which is an enzyme that catalyses the production of intracellular messengers. Metabotropic receptors are the largest family of neurotransmitter receptor. The prototype is the b-adrenergic receptor, which itself has structural (but not amino acid sequence!) homology to the pr ...
Neurotransmitter Systems
... All such neurons contain tyrosine hydroxylase (TH), which catalyzes the first step in catecholamine synthesis, the conversion of tyrosine to a compound called dopa (Ldihydroxyphenylalanine 二羟苯基丙氨酸). The activity of TH is rate limiting for catecholamine synthesis, regulated by various signals in ...
... All such neurons contain tyrosine hydroxylase (TH), which catalyzes the first step in catecholamine synthesis, the conversion of tyrosine to a compound called dopa (Ldihydroxyphenylalanine 二羟苯基丙氨酸). The activity of TH is rate limiting for catecholamine synthesis, regulated by various signals in ...
Muscle
... output (protein kinase activity) takes place • The competition between ATP (inactivate) and AMP (activate) for binding to the AMPK allosteric sites determines the activity of AMPK 1. When [ATP] is high, AMPK is inactive 2. When [AMP] is high, AMPK is allosterically activated and phosphorylates many ...
... output (protein kinase activity) takes place • The competition between ATP (inactivate) and AMP (activate) for binding to the AMPK allosteric sites determines the activity of AMPK 1. When [ATP] is high, AMPK is inactive 2. When [AMP] is high, AMPK is allosterically activated and phosphorylates many ...
