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Bioinformatics Seminar 13/11/07
Bioinformatics Seminar 13/11/07

... GABOS Command Line Version (CLI). • Same code. Program detects environment and adjusts accordingly. • CLI use of GABOS caters for programmatic use of the tool as part of other tasks. – For eg. Collecting 5000 bases before a transcript and 5000 into the transcript to be used for promoter/regulation ...
Characterization and determination of holin protein of Streptococcus suis bacteriophage SMP
Characterization and determination of holin protein of Streptococcus suis bacteriophage SMP

... Holin-lysin lysis systems typically exist in the doublestranded DNA bacteriophages for termination of their growth cycle and release of viral progeny through host cell lysis. By accumulating and forming lesions in the cytoplasmic membrane, holins control access of phageencoded endolysins to the pept ...
The Trouble with Sliding Windows and the Selective Pressure in
The Trouble with Sliding Windows and the Selective Pressure in

... Citation: Schmid K, Yang Z (2008) The Trouble with Sliding Windows and the Selective Pressure in BRCA1. PLoS ONE 3(11): e3746. doi:10.1371/ ...
Pierce5e_ch24_lecturePPT
Pierce5e_ch24_lecturePPT

Molecular tests for coat colours in horses
Molecular tests for coat colours in horses

... For all listed alleles commercial genotyping is possible, except, so far, for Leopard-spotting and White markings. For Dun and Roan zygosity genotyping is possible for some breeds. Definition of mutation types: 1 = missense mutation (non-synonymous mutation) – a nucleotide change (transition, transv ...
A spectrum of genes expressed during early stages of rice... flower development
A spectrum of genes expressed during early stages of rice... flower development

... similarity, function can be hypothesized from RNA and protein synthesis patterns and can be further tested through phenotypic analysis of plants with gain-of-function or lossof-function alleles. These latter molecular-genetic tools are available for both these plant species. Genes expressed in a dev ...
Caloranaerobacter ferrireducens sp. nov., an anaerobic
Caloranaerobacter ferrireducens sp. nov., an anaerobic

... 2009) within the order Deferribacteres, and Geothermobacter ehrlichii (Kashefi et al., 2003) and Deferrisoma camini (Slobodkina et al., 2012) in the class Deltaproteobacteria. So far, only one species, Tepidimicrobium ferriphilum (Slobodkin et al., 2006), isolated from a hot spring, was described as ...
Gene Section MYST4 (MYST histone acetyltransferase (monocytic leukemia) 4)
Gene Section MYST4 (MYST histone acetyltransferase (monocytic leukemia) 4)

... both positive (N-terminus) and negative (C-terminus) regulation of transcription, maybe involved in cerebral cortex development, required for RUNX2 -dependent transcriptional activation and ubiquitously expressed in adult human tissues. ...
Inherited Traits
Inherited Traits

... • Each chromosome is made of protein and a single molecule of DNA. • Comes in matching sets of two • Human cell nucleus contains 46 chromosomes or 23 pairs. • Half of these chromosomes come from one parent and half come from the other parent. ...
Budding yeast Saccharomyces cerevisiae as a model to study
Budding yeast Saccharomyces cerevisiae as a model to study

... first proposed by Joaquim Ros and colleagues (Cabiscol et al., 2000). They found that in aerobically respiring S. cerevisiae cells hydrogen peroxide and menadione induced oxidation of mitochondrial proteins such as E2 subunits of both pyruvate dehydrogenase and α-ketoglutarate dehydrogenase, aconita ...
Khoa hoc - Cong nghe
Khoa hoc - Cong nghe

... coincides with research of scad hydrolysis by Flavourzyme (Chun et al., 2006). A number of other studies on hydrolyzed tuna head (Nguyen et al., 2012) and hydrolysis salmon head (Sathivel et al., 2005) also showed that essential amino acids content in hydrolyzed protein obtained from these studied w ...
Document
Document

... - females have two copies of the sex chromosome (XX) - males have only one (X0). The 0 denotes the absence of a second sex chromosome. - found in numerous insects (grasshoppers, crickets, and cockroaches) and other invertebrates. - C. elegans: male with one sex chromosome (X0); hermaphrodite with a ...
Module 2 In vivo gene therapy Lecture 7 In-situ, in-vivo and
Module 2 In vivo gene therapy Lecture 7 In-situ, in-vivo and

w + gene is silenced in some cells
w + gene is silenced in some cells

... Telomerase activity and cell proliferation In yeast that has deletion of telomerase, telomeres shorten by 3 bp per generation • Eventually the chromosomes break and the cells die In humans, the levels of telomerase and cellular life-span varies between different types of cells • Most somatic cells ...
19.1 Somatostatin Was the First Human Peptide Hormone Produced
19.1 Somatostatin Was the First Human Peptide Hormone Produced

... secretion of a number of other hormones, including growth hormone, insulin, and glucagon. Somatostatin was not chosen for its commercial potential. Instead, it was chosen because the researchers thought it would be technically less difficult than other hormones. Somatostatin is very small (only 14 a ...
Molecule of the Month: AgrA DNA Binding Domain AgrA is the
Molecule of the Month: AgrA DNA Binding Domain AgrA is the

... resolution. The overall fold consists of 10 β-strands that form three β-sheets connected by 310 helices and one alpha helix. Strands 3,4,6 and 7 form the central hydrophobic sheet while amphipathic sheets formed by strands 1,2,5 and 8,9,10 flank it, shielding it from water (Figure 2). The helices p ...
Visual Detection of Useful Genes on Plant Chromosomes
Visual Detection of Useful Genes on Plant Chromosomes

... The phys ical location of the resistance gene to rice leaf blast was then examined. Rice blast caused by Pyricularia 01:i,zae (Mag11apor1/te grisett (Hebert ) Barr) is the most import<1nt fung,11 diseMc or rice. T he resistance gene. Pi-b was cloned into a BAC clone (BACl23) which has a 180 kb inser ...
The Drosophila Cdc6/18 protein has functions in both early and late
The Drosophila Cdc6/18 protein has functions in both early and late

... been reported; however, depletion of the protein in Xenopus extracts causes a block before S phase (Coleman et al., 1996). Dominant negative mutants for mammalian cells (Walker A and B box mutants) cause a stop during the S phase of the cell cycle (Herbig et al., 1999), a result that is consistent w ...
Predicting TF affinities to Promoters of tissue specific genes
Predicting TF affinities to Promoters of tissue specific genes

From Gene to Protein
From Gene to Protein

... 1 When a ribosome reaches a stop 2 The release factor hydrolyzes 3 The two ribosomal subunits codon on mRNA, the A site of the the bond between the tRNA in and the other components of ribosome accepts a protein called the P site and the last amino the assembly dissociate. a release factor instead of ...
Wound Healing and the Importance of Nutrition
Wound Healing and the Importance of Nutrition

... There are however contra-indications with some supplements. The drug warfarin does not interact well with supplements that contain higher levels of Vitamin K as they both have the same effect on the blood and therefore may thin the blood too much. For example, the supplement ‘Arginaid Powder’ contai ...
erci̇yes üni̇versi̇tesi̇ veteri̇ner fakültesi̇ dergi̇si̇
erci̇yes üni̇versi̇tesi̇ veteri̇ner fakültesi̇ dergi̇si̇

... both in milk fat content and in intramuscular fat deposition (21). As obesity was caused by imbalance between energy input - output and calories stored as triglycerides, inhibition of triglyceride synthesis (possible with inhibition of DGAT1 gene) may have a key role in the potential therapeutic str ...
Determination of Amino Acid Composition of Cell Culture Media and
Determination of Amino Acid Composition of Cell Culture Media and

... Amino acids are the basic building blocks of proteins. They constitute all proteinaceous material of the cell including the cytoskeleton and the protein component of enzymes, receptors, and signaling molecules. In addition, amino acids are used for the growth and maintenance of cells. Cell culture m ...
Rate variation during molecular evolution: creationism and the
Rate variation during molecular evolution: creationism and the

... record are used to determine the number of amino acid changes per unit of time, the rate at which a molecular clock is “ticking”. Amino acid sequence comparisons for a specific protein can only be used as a molecular clock due to mutations in the gene coding for that protein. These mutations take pl ...
Structure of a Functional Amyloid Protein Subunit Computed Using
Structure of a Functional Amyloid Protein Subunit Computed Using

... In contrast to disease-related amyloids caused by protein misfolding, functional amyloids are ‘beneficial’ aggregation systems that are evolved by nature and evolutionarily conserved across species.2 This suggests that there is an evolutionary pressure to maintain the amyloid structure of these prote ...
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Point mutation



A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.
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