The RAGNYA fold: a novel fold with multiple topological variants
... (and the related EI barrel), b-grasp, S5-like fold, HhH (helix-hairpin-helix) and HTH (helix-turn-helix) [for further details see the SCOP database (1)]. These folds are not only found in proteins that passively interact with nucleic acids, but also form the catalytic domains of several key enzymes ...
... (and the related EI barrel), b-grasp, S5-like fold, HhH (helix-hairpin-helix) and HTH (helix-turn-helix) [for further details see the SCOP database (1)]. These folds are not only found in proteins that passively interact with nucleic acids, but also form the catalytic domains of several key enzymes ...
Amino Acids Interp Guide
... Amino acids are the building blocks that make up protein in all bodily tissues, including bone, muscles, ligaments, tendons, nails, hair, glands and organs. Amino acids are also the basic constituents of all hormones, enzymes and neurotransmitters. Assessment of amino acid levels will help to identi ...
... Amino acids are the building blocks that make up protein in all bodily tissues, including bone, muscles, ligaments, tendons, nails, hair, glands and organs. Amino acids are also the basic constituents of all hormones, enzymes and neurotransmitters. Assessment of amino acid levels will help to identi ...
Direct visualization of protein interactions in plant cells
... time points after addition of SA (Fig. 4). We allowed a 10 h expression period after electroporation to allow the accumulation of the interacting proteins before addition of fMTX and SA. The NPR1/NIM1–TGA2 interaction shows a biphasic mode of interaction in response to SA treatment (Fig. 4), with an ...
... time points after addition of SA (Fig. 4). We allowed a 10 h expression period after electroporation to allow the accumulation of the interacting proteins before addition of fMTX and SA. The NPR1/NIM1–TGA2 interaction shows a biphasic mode of interaction in response to SA treatment (Fig. 4), with an ...
Preparing and Analyzing Expressed Sequence Tags (ESTs) Library
... intake of newborn lambs in the first days of their lives plays essential role in their healthy growth and reaching to ideal market weight [9]. The raisers are desired to breed very productive animal, so colostrums secretion is a crucially important stage for breeding. Because the compounds of colost ...
... intake of newborn lambs in the first days of their lives plays essential role in their healthy growth and reaching to ideal market weight [9]. The raisers are desired to breed very productive animal, so colostrums secretion is a crucially important stage for breeding. Because the compounds of colost ...
Effects of signaling on subcellular localization of MITF
... Figure 1: The difference between CSD and non-CSD melanomas ....................................... 2 Figure 2: Melanoma in naevi................................................................................................. 3 Figure 3: MITF crystal structures..................................... ...
... Figure 1: The difference between CSD and non-CSD melanomas ....................................... 2 Figure 2: Melanoma in naevi................................................................................................. 3 Figure 3: MITF crystal structures..................................... ...
"Tooth Agenesis". - Thimios Mitsiadis
... predicted that the consequences of the genetic defects are either severely truncated proteins or proteins with a deficient capacity to bind to DNA. Thus, in a heterozygous condition where one allele is mutated whereas the other allele is normal, the amount of the fully functional gene products is red ...
... predicted that the consequences of the genetic defects are either severely truncated proteins or proteins with a deficient capacity to bind to DNA. Thus, in a heterozygous condition where one allele is mutated whereas the other allele is normal, the amount of the fully functional gene products is red ...
The Structural, Biochemical, and Genetic Characterization of a New
... A variegated leaf mutant in soybean [Glycine max (L.) Merr.] has been identified and characterized. E25-10 was derived by exposure of seeds of the “Williams’ 82” cultivar to γ-radiation. In this mutant, yellow leaf sectors contain defective chloroplasts, in which the thylakoid membranes are presente ...
... A variegated leaf mutant in soybean [Glycine max (L.) Merr.] has been identified and characterized. E25-10 was derived by exposure of seeds of the “Williams’ 82” cultivar to γ-radiation. In this mutant, yellow leaf sectors contain defective chloroplasts, in which the thylakoid membranes are presente ...
Hemoglobin Variant Trait
... In the unlikely event that BOTH OF YOU CARRY A HEMOGLOBIN VARIANT or ONE OF YOU CARRY A HEMOGLOBIN VARIANT and the OTHER CARRIES ANOTHER TYPE OF UNUSUAL HEMOGLOBIN, the risk in the next pregnancy will depend on what type of Why is it important to understand that my variant or other unusual hemoglobi ...
... In the unlikely event that BOTH OF YOU CARRY A HEMOGLOBIN VARIANT or ONE OF YOU CARRY A HEMOGLOBIN VARIANT and the OTHER CARRIES ANOTHER TYPE OF UNUSUAL HEMOGLOBIN, the risk in the next pregnancy will depend on what type of Why is it important to understand that my variant or other unusual hemoglobi ...
chromosome disorders.
... • Aneuploidy is the most common and clinically significant type of human chromosome disorder, occurring in at least 5% of all clinically recognized pregnancies. • Most aneuploid patients have either trisomy or, less often, monosomy • Trisomy can exist for any part of the genome, but trisomy for a wh ...
... • Aneuploidy is the most common and clinically significant type of human chromosome disorder, occurring in at least 5% of all clinically recognized pregnancies. • Most aneuploid patients have either trisomy or, less often, monosomy • Trisomy can exist for any part of the genome, but trisomy for a wh ...
Vegetative incompatibility in filamentous fungi: Podospora and
... amino-acid replacements in the P. anserina het-S gene product give rise to a protein of the antagonistic [Het-s] specificity [19,20•]. Similarly, single amino-acid substitutions in the HET-C protein of P. anserina can modify its specificity in incompatibility [21]. An amino-acid replacement in the N ...
... amino-acid replacements in the P. anserina het-S gene product give rise to a protein of the antagonistic [Het-s] specificity [19,20•]. Similarly, single amino-acid substitutions in the HET-C protein of P. anserina can modify its specificity in incompatibility [21]. An amino-acid replacement in the N ...
A NEW TAIL-SHORT MUTATION IN THE MOUSE
... Adult "tail-short" mice showing type 2 short tails which appear as a mutant in the sixty-second generation of an inbred strain (See Figure 5). Mice homozygous for the T-s gene appear to be inviable. tail measurements of 103 mm. ± 5 mm. The mutant mice have a slightly shortened body, 85-95 mm., and g ...
... Adult "tail-short" mice showing type 2 short tails which appear as a mutant in the sixty-second generation of an inbred strain (See Figure 5). Mice homozygous for the T-s gene appear to be inviable. tail measurements of 103 mm. ± 5 mm. The mutant mice have a slightly shortened body, 85-95 mm., and g ...
Mitochondrial stress causes increased succination of proteins in
... extent in insulin-resistant DIO (diet-induced obese) mice [10]. Nutrient excess has been documented to result in mitochondrial damage in the expanding adipocyte [11,12], suggesting that an increase in mitochondrial stress occurs as a result of fuel excess [13,14]. Intra-adipocyte organelle stress [1 ...
... extent in insulin-resistant DIO (diet-induced obese) mice [10]. Nutrient excess has been documented to result in mitochondrial damage in the expanding adipocyte [11,12], suggesting that an increase in mitochondrial stress occurs as a result of fuel excess [13,14]. Intra-adipocyte organelle stress [1 ...
Deconstructing the Genome: DNA at High Resolution
... bloodstream, but the amount of oxygen in the maternal circulation is less than that found in the air that enters our lungs after birth. Both embryonic and fetal hemoglobin evolved to bind oxygen more tightly than adult hemoglobin would at the lower levels of oxygen found in the embryonic and fetal e ...
... bloodstream, but the amount of oxygen in the maternal circulation is less than that found in the air that enters our lungs after birth. Both embryonic and fetal hemoglobin evolved to bind oxygen more tightly than adult hemoglobin would at the lower levels of oxygen found in the embryonic and fetal e ...
Repair of Site-Specific DNA Double-Strand Breaks in
... bp; often linked with classical NHEJ) and longer deletions (indicating alternative end joining; Deriano and Roth, 2013) both accompanied by small (#3 bp) insertions at the break sites and ligated with (MMEJ) or without using microhomology of #25 bp. From a total of 7668 informative reads obtained fr ...
... bp; often linked with classical NHEJ) and longer deletions (indicating alternative end joining; Deriano and Roth, 2013) both accompanied by small (#3 bp) insertions at the break sites and ligated with (MMEJ) or without using microhomology of #25 bp. From a total of 7668 informative reads obtained fr ...
Cysteine 230 Modulates Tumor Necrosis Factor
... cysteine residue was conserved in mouse TRAIL protein (10), pointing to a key functional role for this amino acid residue in the biological function of TRAIL protein. To examine the contribution of this cysteine residue, the cysteine was mutated to glycine (Fig. 3A), and TRAIL (C230G) protein was pu ...
... cysteine residue was conserved in mouse TRAIL protein (10), pointing to a key functional role for this amino acid residue in the biological function of TRAIL protein. To examine the contribution of this cysteine residue, the cysteine was mutated to glycine (Fig. 3A), and TRAIL (C230G) protein was pu ...
AccessMedicine | Print: Cha
... DNA & RNA ARE POLYNUCLEOTIDES The 5'-phosphoryl group of a mononucleotide can esterify a second hydroxyl group, forming a phosphodiester. Most commonly, this second hydroxyl group is the 3'-OH of the pentose of a second nucleotide. This forms a dinucleotide in which the pentose moieties are linked b ...
... DNA & RNA ARE POLYNUCLEOTIDES The 5'-phosphoryl group of a mononucleotide can esterify a second hydroxyl group, forming a phosphodiester. Most commonly, this second hydroxyl group is the 3'-OH of the pentose of a second nucleotide. This forms a dinucleotide in which the pentose moieties are linked b ...
Replicational and transcriptional selection on codon usage in
... level of replication. An organism that can replicate more quickly could have a selective advantage over one whose replication is retarded. It was pointed out by Fraser et al. (7) that approximately two-thirds of the genes on the B. burgdorferi genome were transcribed away from the origin of replicat ...
... level of replication. An organism that can replicate more quickly could have a selective advantage over one whose replication is retarded. It was pointed out by Fraser et al. (7) that approximately two-thirds of the genes on the B. burgdorferi genome were transcribed away from the origin of replicat ...
The Molecular Basis of Imidazolinone Herbicide Resistance in
... products of the biosynthetic pathway valine, leucine, and isoleucine. ALS from maize has been partially purified and characterized (Muhitch et al., 1987). Since ALS is a labile enzyme it is very difficult to purify the active protein to homogeneity for further characterization and preparation of ant ...
... products of the biosynthetic pathway valine, leucine, and isoleucine. ALS from maize has been partially purified and characterized (Muhitch et al., 1987). Since ALS is a labile enzyme it is very difficult to purify the active protein to homogeneity for further characterization and preparation of ant ...
ref. #28 of the TIBS article
... structure, and have located Ala25 and Thr46 in a somewhat hydrophobic environment close to the membrane/water interface (Spruijt et al., 1996; Stopar et al., 1996). As seen in Figure 1(b), this places the Ca atom of residue Lys40 well into the hydrophobic part of the bilayer. A segment encompassing ...
... structure, and have located Ala25 and Thr46 in a somewhat hydrophobic environment close to the membrane/water interface (Spruijt et al., 1996; Stopar et al., 1996). As seen in Figure 1(b), this places the Ca atom of residue Lys40 well into the hydrophobic part of the bilayer. A segment encompassing ...
pSAT vectors: a modular series of plasmids for autofluorescent
... Assembly of several pSAT expression cassettes into single plasmids For expression of two autofluorescently-tagged proteins from a single plasmid, we first produced pSAT1-ECFP-C1-VIP1 by cloning the VIP1 ORF as a SalI-BamHI fragment from pSAT6EGFP-C1-VIP1 into pSAT1-ECFP-C1. The ECFP-VIP1 expression ...
... Assembly of several pSAT expression cassettes into single plasmids For expression of two autofluorescently-tagged proteins from a single plasmid, we first produced pSAT1-ECFP-C1-VIP1 by cloning the VIP1 ORF as a SalI-BamHI fragment from pSAT6EGFP-C1-VIP1 into pSAT1-ECFP-C1. The ECFP-VIP1 expression ...
Biology: semester one: course outline
... List the four major classes of macromolecules. Draw diagrams to illustrate condensation and hydrolysis reactions. Distinguish between monosaccharides, disaccharides, and polysaccharides. Describe the formation of a glycosidic linkage, and distinguish between the glycosidic linkages found in starch a ...
... List the four major classes of macromolecules. Draw diagrams to illustrate condensation and hydrolysis reactions. Distinguish between monosaccharides, disaccharides, and polysaccharides. Describe the formation of a glycosidic linkage, and distinguish between the glycosidic linkages found in starch a ...
Are Hydrophobins and/or Non-Specific Lipid Transfer Proteins
... However, in brewing technology the formation and stability of foam are important criteria concerning beer quality. Sørensen and co-workers (1993) reported that barley LTP1 is involved in beer foam formation. LTP1 purified from beer created a good beer foam with high potential in a foam assay. In con ...
... However, in brewing technology the formation and stability of foam are important criteria concerning beer quality. Sørensen and co-workers (1993) reported that barley LTP1 is involved in beer foam formation. LTP1 purified from beer created a good beer foam with high potential in a foam assay. In con ...
Chapter 5
... • Sickle-cell disease, an inherited blood disorder, results from a single amino acid substitution in the protein hemoglobin Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
... • Sickle-cell disease, an inherited blood disorder, results from a single amino acid substitution in the protein hemoglobin Copyright © 2008 Pearson Education, Inc., publishing as Pearson Benjamin Cummings ...
Point mutation
A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.