Ablation of Proliferating Cells in the CNS
... acquired from The Jackson Laboratory (Bar Harbor, ME). Mice were genotyped in accordance with Jackson Laboratory protocols. The use and maintenance of the mice described in this article were performed in accordance to the Guide of Care and Use of Experimental Animals of the Canadian Council on Anima ...
... acquired from The Jackson Laboratory (Bar Harbor, ME). Mice were genotyped in accordance with Jackson Laboratory protocols. The use and maintenance of the mice described in this article were performed in accordance to the Guide of Care and Use of Experimental Animals of the Canadian Council on Anima ...
Evidence for specific immune response against P210 BCR
... CML is a pluripotent stem cell disease that primarily affects myeloid lineages in chronic phase. The disease almost always progresses to the blast crisis stage, which is the terminal stage. Therapy of CML with interferon (IFN) is associated with frequent hematopoietic remissions and complete cytogen ...
... CML is a pluripotent stem cell disease that primarily affects myeloid lineages in chronic phase. The disease almost always progresses to the blast crisis stage, which is the terminal stage. Therapy of CML with interferon (IFN) is associated with frequent hematopoietic remissions and complete cytogen ...
Mycobacterial immune reconstitution inflammatory syndrome in HIV
... reflect effective immune surveillance, mimicking the beneficial T-cell responses seen in untreated long-term nonprogressors, HIV-1 exposed but seronegative individuals, and after therapeutic vaccination of asymptomatic patients [8-10]. It has been postulated that after treatment of late-stage HIV-1 ...
... reflect effective immune surveillance, mimicking the beneficial T-cell responses seen in untreated long-term nonprogressors, HIV-1 exposed but seronegative individuals, and after therapeutic vaccination of asymptomatic patients [8-10]. It has been postulated that after treatment of late-stage HIV-1 ...
2008 - The Ohio State University College of Medicine
... P p 0.02) and IgG2a (univariate F1, 29 p 67.5, P ! 0.001) secondary responses against KLH, as indicated by elevated antibody titers 5 d after the second KLH challenge. To ascertain whether FR affected secondary antibody responses, we examined IgG1 and IgG2a titers 5 d after the secondary antigen cha ...
... P p 0.02) and IgG2a (univariate F1, 29 p 67.5, P ! 0.001) secondary responses against KLH, as indicated by elevated antibody titers 5 d after the second KLH challenge. To ascertain whether FR affected secondary antibody responses, we examined IgG1 and IgG2a titers 5 d after the secondary antigen cha ...
Antigen-non-specific regulation centered on CD25+Foxp3+
... however, excessive responses result in self-damage. Activation-induced cell death might be an intracellular mechanism to control excessive immune responses, but this negative feedback may be unable to detect an excessive response that threatens to cause self-destruction. Here, we propose that antige ...
... however, excessive responses result in self-damage. Activation-induced cell death might be an intracellular mechanism to control excessive immune responses, but this negative feedback may be unable to detect an excessive response that threatens to cause self-destruction. Here, we propose that antige ...
40-2 The Immune System
... deliberate exposure. Natural immunity occurs when antibodies produced by the mother are passed to the fetus during development or in early infancy through breast milk. Passive immunity also occurs when antibodies are administered to fight infection or prevent disease. ...
... deliberate exposure. Natural immunity occurs when antibodies produced by the mother are passed to the fetus during development or in early infancy through breast milk. Passive immunity also occurs when antibodies are administered to fight infection or prevent disease. ...
Human IL-23-producing type 1 macrophages promote but IL
... genetic deficiencies in this type 1 cytokine signaling cascade (affecting IL-12p40, IL-12R, IFN-␥R, or STAT-1) lead to increased susceptibility to otherwise weakly pathogenic mycobacteria and salmonellae (reviewed in ref. 1). Dendritic cells (DCs) are highly potent phagocytes that prime naive T cell ...
... genetic deficiencies in this type 1 cytokine signaling cascade (affecting IL-12p40, IL-12R, IFN-␥R, or STAT-1) lead to increased susceptibility to otherwise weakly pathogenic mycobacteria and salmonellae (reviewed in ref. 1). Dendritic cells (DCs) are highly potent phagocytes that prime naive T cell ...
Analysis of a wild mouse promoter variant reveals a novel role
... Genetic variants of the inhibitory Fc receptor FcRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown and was investigated by knocking in the most commonly conserved wild mouse ...
... Genetic variants of the inhibitory Fc receptor FcRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown and was investigated by knocking in the most commonly conserved wild mouse ...
The Role of a Cytophilic Factor from Challenged
... hr. These SL2 cells were washed 3 times and added to normal macrophage monolayers at a concentration of 2 X 10@ SL2 cells in 3 ml of growth medium. Coating of the cells is incomplete or borderline at concentrations of iO' and 108 SL2 cells/ml, respectively (Table 8). Following the coating of lymphom ...
... hr. These SL2 cells were washed 3 times and added to normal macrophage monolayers at a concentration of 2 X 10@ SL2 cells in 3 ml of growth medium. Coating of the cells is incomplete or borderline at concentrations of iO' and 108 SL2 cells/ml, respectively (Table 8). Following the coating of lymphom ...
22.4 How Does The Immune System Launch An Attack?
... there, waiting for an appropriate antigen. • Virtually every antigen can be bound by at least a few antibodies because of the immense numbers of antibodies present in the body. Copyright © 2009 Pearson Education Inc. ...
... there, waiting for an appropriate antigen. • Virtually every antigen can be bound by at least a few antibodies because of the immense numbers of antibodies present in the body. Copyright © 2009 Pearson Education Inc. ...
Syllbus File - Al-Hussein Bin Talal University
... 1. To master the concept of major histocompatibility complex 2. To be familiar with the nomenclature of MHC 3. To be familiar with the composition and classification of HLA gene locus 4. To master the structural characteristics, distribution and biological function of human HLA-I and II antigens 5. ...
... 1. To master the concept of major histocompatibility complex 2. To be familiar with the nomenclature of MHC 3. To be familiar with the composition and classification of HLA gene locus 4. To master the structural characteristics, distribution and biological function of human HLA-I and II antigens 5. ...
Copyright © 2014 Cognizant Communication Corporation CT
... neuroinflammation and -degeneration (56,66). Furthermore, complex interactions with other peripheral immune cells and CNS-resident cells are responsible for repeated episodes of autoimmune-mediated damage to myelin and oligodendrocytes (14,69). Over time, recurring demyelination and fading CNS repai ...
... neuroinflammation and -degeneration (56,66). Furthermore, complex interactions with other peripheral immune cells and CNS-resident cells are responsible for repeated episodes of autoimmune-mediated damage to myelin and oligodendrocytes (14,69). Over time, recurring demyelination and fading CNS repai ...
The Adjuvants Aluminum Hydroxide And MF59 Induce Monocyte And
... shown). Gated cells up-regulate the costimulatory molecule CD86 (B7-2) and down-regulate the monocyte lineage marker CD14 (Fig. 2B, bottom). None of these changes were induced by LPS. Similar effects were found on pure monocytes (data not shown). No other cell type present in PBMCs showed any phenot ...
... shown). Gated cells up-regulate the costimulatory molecule CD86 (B7-2) and down-regulate the monocyte lineage marker CD14 (Fig. 2B, bottom). None of these changes were induced by LPS. Similar effects were found on pure monocytes (data not shown). No other cell type present in PBMCs showed any phenot ...
University of Groningen Bottlenecks, budgets and immunity
... the liver produces acute phase proteins and diverts amino acids away from normal processes (such as growth or reproduction). In addition, regular body cells increase protein turnover and MHC type I presentation to CD8 T-cells. At the same time dendritic cells, which have engulfed the pathogen, are m ...
... the liver produces acute phase proteins and diverts amino acids away from normal processes (such as growth or reproduction). In addition, regular body cells increase protein turnover and MHC type I presentation to CD8 T-cells. At the same time dendritic cells, which have engulfed the pathogen, are m ...
A Hypomorphic IgH-Chain Allele Affects Development of B
... of impaired signaling from the pre-BCR and BCR, they show only one Ca-flux experiment after antigen stimulation (Fig. 4D), where speed and amplitude of the Ca-response to BCR stimulation does not differ between IgHEµ-GFP/Eµ-GFP and IgHb/b MZ B-cells. Brenner et al. present IgHEµGFP/Eµ-GFP hypomorphi ...
... of impaired signaling from the pre-BCR and BCR, they show only one Ca-flux experiment after antigen stimulation (Fig. 4D), where speed and amplitude of the Ca-response to BCR stimulation does not differ between IgHEµ-GFP/Eµ-GFP and IgHb/b MZ B-cells. Brenner et al. present IgHEµGFP/Eµ-GFP hypomorphi ...
EFFECT OF CROTALUS ATROX VENOM ON PERITONEAL AND SPLEEN CELL... PRODUCTION
... toxins, enzymes, growth factors, activators and inhibitors with a wide spectrum of biological activities. The effect of Crotalus atrox venom on human is characterized by cardiovascular system, respiratory system, somatic nerve system, and skeletal muscle [1]. The local effects caused by this venom a ...
... toxins, enzymes, growth factors, activators and inhibitors with a wide spectrum of biological activities. The effect of Crotalus atrox venom on human is characterized by cardiovascular system, respiratory system, somatic nerve system, and skeletal muscle [1]. The local effects caused by this venom a ...
IMPROVE IMMunIty
... Each of the 100 species of common disease-causing bacteria now has at least one strain that is resistant to antibiotics. That number is rapidly increasing, becoming a major medical threat. The overuse of antibiotics (which literally means “against life”) is a contributing factor in weakening the imm ...
... Each of the 100 species of common disease-causing bacteria now has at least one strain that is resistant to antibiotics. That number is rapidly increasing, becoming a major medical threat. The overuse of antibiotics (which literally means “against life”) is a contributing factor in weakening the imm ...
TGFb Treatment Enhances Glioblastoma
... safety profile in phase III malignant melanoma trials (6). Oncolytic viruses have attracted particular attention as distinctive antiglioblastoma biologic agents, due not only to the relatively restricted localization of glioblastoma in the brain but also to the fact that the surrounding normal cells ...
... safety profile in phase III malignant melanoma trials (6). Oncolytic viruses have attracted particular attention as distinctive antiglioblastoma biologic agents, due not only to the relatively restricted localization of glioblastoma in the brain but also to the fact that the surrounding normal cells ...
Respiratory epithelial cells orchestrate pulmonary innate immunity
... downstream host-defense responses. PAMPs derived from commensal microbes or respiratory pathogens and DAMPs generated from cell stress and/or death within both the conducting airways and alveoli are recognized via membraneassociated or cytosolic PRRs expressed in respiratory epithelial cells. The bi ...
... downstream host-defense responses. PAMPs derived from commensal microbes or respiratory pathogens and DAMPs generated from cell stress and/or death within both the conducting airways and alveoli are recognized via membraneassociated or cytosolic PRRs expressed in respiratory epithelial cells. The bi ...
Innate Immunity Underlies Symbiotic Relationships
... restricting penetration of bacteria into internal environment of the body; surveillance and control for inhabitant microbes; creation and continuous maintenance of conditions hampering development of inflammation; preservation and transfer of beneficial microbes to progeny. The abovementioned tasks ...
... restricting penetration of bacteria into internal environment of the body; surveillance and control for inhabitant microbes; creation and continuous maintenance of conditions hampering development of inflammation; preservation and transfer of beneficial microbes to progeny. The abovementioned tasks ...
Booster Vaccinations against Cancer Are Critical
... cells, mice were primed with DC-Tag and either boosted 4 weeks later with DC-Tag or with the Tag peptide emulsified in CFA. Other groups of mice were subjected only to the needle injury (Sham), or were boosted with DC w/o, or left untreated (Nil; Fig. 3A). By 6 weeks after boosting, while Tag-specific ...
... cells, mice were primed with DC-Tag and either boosted 4 weeks later with DC-Tag or with the Tag peptide emulsified in CFA. Other groups of mice were subjected only to the needle injury (Sham), or were boosted with DC w/o, or left untreated (Nil; Fig. 3A). By 6 weeks after boosting, while Tag-specific ...
T cell
T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.