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Figure 16.20 Activation of T cells
Figure 16.20 Activation of T cells

Nonspecific immune defenses
Nonspecific immune defenses

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19-T-cell differentiation-Thymus_LÁ

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... The earliest developing thymocytes lack the expression of the co-receptors CD4 and CD8 and are termed double negative (DN) cells. The DN population can be further sub-divided by the expression of CD44 (an adhesion molecule) and CD25 (Interleukin-2 receptor α chain), Figure 1 shows the ordered expres ...
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... Why should I care? There is currently a great deal of evidence that suggests that people who are routinely exposed to many pathogens have a much lower chance of developing an autoimmune disease. This is known as the "hygiene hypothesis". 15. Suggest a possible explanation for this observed phenomeno ...
Cells and Organs of the Immune System
Cells and Organs of the Immune System

... balance between cells removed by cell death and those produced -for WBC’s: a human must produce ~3.7 x 1011/day ! ...
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T cell



T cells or T lymphocytes are a type of lymphocyte (in turn, a type of white blood cell) that plays a central role in cell-mediated immunity. They can be distinguished from other lymphocytes, such as B cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. They are called T cells because they mature in the thymus (although some also mature in the tonsils). The several subsets of T cells each have a distinct function. The majority of human T cells rearrange their alpha/beta T cell receptors and are termed alpha beta T cells and are part of adaptive immune system. Specialized gamma delta T cells, which comprise a minority of T cells in the human body (more frequent in ruminants), have invariant TCR (with limited diversity), can effectively present antigens to other T cells and are considered to be part of the innate immune system.
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